8TTB

Cryo-EM structure of the PP2A:B55-ARPP19 complex

Summary for 8TTB

• Entry DOI: 10.2210/pdb8ttb/pdb
• EMDB information: 41604
• Descriptor: Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform, Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform, Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform, ... (6 entities in total)
• Functional Keywords: protein phosphatase 2a:b55 holoenzyme, arpp19 inhibitor, cell cycle regulation, signaling protein, hydrolase
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 4
• Total formula weight: 165589.14

Authors

Fuller, J.R.,Padi, S.K.R.,Peti, W.,Page, R. (deposition date: 2023-08-13, release date: 2023-10-25, Last modification date: 2024-01-17)

• Primary citation: Padi, S.K.R.,Vos, M.R.,Godek, R.J.,Fuller, J.R.,Kruse, T.,Hein, J.B.,Nilsson, J.,Kelker, M.S.,Page, R.,Peti, W.; Cryo-EM structures of PP2A:B55-FAM122A and PP2A:B55-ARPP19.; Nature, 625:195-203, 2024; PubMed: 38123684; DOI: 10.1038/s41586-023-06870-3

Experimental method

ELECTRON MICROSCOPY (2.77 Å)