7TVF

Crystal structure of the SHOC2-MRAS-PP1CA (SMP) complex to a resolution of 2.17 Angstrom

Summary for 7TVF

Entry DOI	10.2210/pdb7tvf/pdb
Descriptor	Serine/threonine-protein phosphatase PP1-alpha catalytic subunit, PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER, MAGNESIUM ION, ... (12 entities in total)
Functional Keywords	oncoprotein phosphatase scaffold protein adaptor ras leucine rich repeat, signaling protein
Biological source	Homo sapiens (human) More
Total number of polymer chains	6
Total formula weight	249100.53
Authors	Bonsor, D.A.,Simanshu, D.K. (deposition date: 2022-02-04, release date: 2022-05-04, Last modification date: 2023-10-18)
Primary citation	Bonsor, D.A.,Alexander, P.,Snead, K.,Hartig, N.,Drew, M.,Messing, S.,Finci, L.I.,Nissley, D.V.,McCormick, F.,Esposito, D.,Rodriguez-Viciana, P.,Stephen, A.G.,Simanshu, D.K. Structure of the SHOC2-MRAS-PP1C complex provides insights into RAF activation and Noonan syndrome. Nat.Struct.Mol.Biol., 29:966-977, 2022 Cited by PubMed: 36175670 DOI: 10.1038/s41594-022-00841-4 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.17 Å)

Structure validation