7TVF
Crystal structure of the SHOC2-MRAS-PP1CA (SMP) complex to a resolution of 2.17 Angstrom
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | F, C | Serine/threonine-protein phosphatase PP1-alpha catalytic subunit | polymer | 329 | 37426.9 | 2 | UniProt (P62136) Pfam (PF16891) Pfam (PF00149) In PDB | Homo sapiens (human) | PP-1A |
2 | E, B | Ras-related protein M-Ras | polymer | 179 | 20426.3 | 2 | UniProt (O14807) Pfam (PF00071) In PDB | Homo sapiens (human) | Ras-related protein R-Ras3 |
3 | A, D | Leucine-rich repeat protein SHOC-2 | polymer | 582 | 64898.7 | 2 | UniProt (Q9UQ13) Pfam (PF13855) In PDB | Homo sapiens (human) | Protein soc-2 homolog,Protein sur-8 homolog |
4 | B, A, F, D, C... | GLYCEROL | non-polymer | 92.1 | 13 | Chemie (GOL) | |||
5 | B, A, F, D, C... | SULFATE ION | non-polymer | 96.1 | 8 | Chemie (SO4) | |||
6 | F, C | MANGANESE (II) ION | non-polymer | 54.9 | 4 | Chemie (MN) | |||
7 | F, E | SODIUM ION | non-polymer | 23.0 | 2 | Chemie (NA) | |||
8 | F | PHOSPHATE ION | non-polymer | 95.0 | 1 | Chemie (PO4) | |||
9 | A, F, D | CHLORIDE ION | non-polymer | 35.5 | 5 | Chemie (CL) | |||
10 | E, B | PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER | non-polymer | 522.2 | 2 | Chemie (GNP) | |||
11 | B, E | MAGNESIUM ION | non-polymer | 24.3 | 2 | Chemie (MG) | |||
12 | water | water | 18.0 | 1046 | Chemie (HOH) |
Sequence modifications
E, B: 1 - 178 (UniProt: O14807)
A, D: 2 - 582 (UniProt: Q9UQ13)
PDB | External Database | Details |
---|---|---|
Gly 0 | - | expression tag |
Leu 71 | Gln 71 | engineered mutation |
PDB | External Database | Details |
---|---|---|
Gly 1 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 6 |
Total formula weight | 245503.8 | |
Non-Polymers* | Number of molecules | 37 |
Total formula weight | 3596.7 | |
All* | Total formula weight | 249100.5 |