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7TVF

Crystal structure of the SHOC2-MRAS-PP1CA (SMP) complex to a resolution of 2.17 Angstrom

Functional Information from GO Data
ChainGOidnamespacecontents
A0000164cellular_componentprotein phosphatase type 1 complex
A0005515molecular_functionprotein binding
A0005634cellular_componentnucleus
A0005654cellular_componentnucleoplasm
A0005737cellular_componentcytoplasm
A0005829cellular_componentcytosol
A0007165biological_processsignal transduction
A0007265biological_processRas protein signal transduction
A0008157molecular_functionprotein phosphatase 1 binding
A0008543biological_processfibroblast growth factor receptor signaling pathway
A0010976biological_processpositive regulation of neuron projection development
A0019888molecular_functionprotein phosphatase regulator activity
A0019903molecular_functionprotein phosphatase binding
A0038180biological_processnerve growth factor signaling pathway
A0045665biological_processnegative regulation of neuron differentiation
A0045666biological_processpositive regulation of neuron differentiation
A0046579biological_processpositive regulation of Ras protein signal transduction
A0071378biological_processcellular response to growth hormone stimulus
A0140361biological_processcyclic-GMP-AMP transmembrane import across plasma membrane
A2000178biological_processnegative regulation of neural precursor cell proliferation
B0003924molecular_functionGTPase activity
B0005525molecular_functionGTP binding
B0007165biological_processsignal transduction
B0016020cellular_componentmembrane
C0000164cellular_componentprotein phosphatase type 1 complex
C0000781cellular_componentchromosome, telomeric region
C0004721molecular_functionphosphoprotein phosphatase activity
C0004722molecular_functionprotein serine/threonine phosphatase activity
C0005506molecular_functioniron ion binding
C0005515molecular_functionprotein binding
C0005634cellular_componentnucleus
C0005654cellular_componentnucleoplasm
C0005730cellular_componentnucleolus
C0005737cellular_componentcytoplasm
C0005829cellular_componentcytosol
C0005886cellular_componentplasma membrane
C0005912cellular_componentadherens junction
C0005977biological_processglycogen metabolic process
C0005979biological_processregulation of glycogen biosynthetic process
C0005981biological_processregulation of glycogen catabolic process
C0006470biological_processprotein dephosphorylation
C0008157molecular_functionprotein phosphatase 1 binding
C0010288biological_processresponse to lead ion
C0016311biological_processdephosphorylation
C0016787molecular_functionhydrolase activity
C0016791molecular_functionphosphatase activity
C0017018molecular_functionmyosin phosphatase activity
C0030324biological_processlung development
C0032922biological_processcircadian regulation of gene expression
C0042587cellular_componentglycogen granule
C0042752biological_processregulation of circadian rhythm
C0043021molecular_functionribonucleoprotein complex binding
C0043025cellular_componentneuronal cell body
C0043153biological_processentrainment of circadian clock by photoperiod
C0043197cellular_componentdendritic spine
C0043204cellular_componentperikaryon
C0043247biological_processtelomere maintenance in response to DNA damage
C0043558biological_processregulation of translational initiation in response to stress
C0044877molecular_functionprotein-containing complex binding
C0045725biological_processpositive regulation of glycogen biosynthetic process
C0046872molecular_functionmetal ion binding
C0046914molecular_functiontransition metal ion binding
C0048754biological_processbranching morphogenesis of an epithelial tube
C0051301biological_processcell division
C0060828biological_processregulation of canonical Wnt signaling pathway
C0070062cellular_componentextracellular exosome
C0072357cellular_componentPTW/PP1 phosphatase complex
C0098609biological_processcell-cell adhesion
C0098641molecular_functioncadherin binding involved in cell-cell adhesion
C0098793cellular_componentpresynapse
C0098794cellular_componentpostsynapse
C0098978cellular_componentglutamatergic synapse
C2001241biological_processpositive regulation of extrinsic apoptotic signaling pathway in absence of ligand
D0000164cellular_componentprotein phosphatase type 1 complex
D0005515molecular_functionprotein binding
D0005634cellular_componentnucleus
D0005654cellular_componentnucleoplasm
D0005737cellular_componentcytoplasm
D0005829cellular_componentcytosol
D0007165biological_processsignal transduction
D0007265biological_processRas protein signal transduction
D0008157molecular_functionprotein phosphatase 1 binding
D0008543biological_processfibroblast growth factor receptor signaling pathway
D0010976biological_processpositive regulation of neuron projection development
D0019888molecular_functionprotein phosphatase regulator activity
D0019903molecular_functionprotein phosphatase binding
D0038180biological_processnerve growth factor signaling pathway
D0045665biological_processnegative regulation of neuron differentiation
D0045666biological_processpositive regulation of neuron differentiation
D0046579biological_processpositive regulation of Ras protein signal transduction
D0071378biological_processcellular response to growth hormone stimulus
D0140361biological_processcyclic-GMP-AMP transmembrane import across plasma membrane
D2000178biological_processnegative regulation of neural precursor cell proliferation
E0003924molecular_functionGTPase activity
E0005525molecular_functionGTP binding
E0007165biological_processsignal transduction
E0016020cellular_componentmembrane
F0000164cellular_componentprotein phosphatase type 1 complex
F0000781cellular_componentchromosome, telomeric region
F0004721molecular_functionphosphoprotein phosphatase activity
F0004722molecular_functionprotein serine/threonine phosphatase activity
F0005506molecular_functioniron ion binding
F0005515molecular_functionprotein binding
F0005634cellular_componentnucleus
F0005654cellular_componentnucleoplasm
F0005730cellular_componentnucleolus
F0005737cellular_componentcytoplasm
F0005829cellular_componentcytosol
F0005886cellular_componentplasma membrane
F0005912cellular_componentadherens junction
F0005977biological_processglycogen metabolic process
F0005979biological_processregulation of glycogen biosynthetic process
F0005981biological_processregulation of glycogen catabolic process
F0006470biological_processprotein dephosphorylation
F0008157molecular_functionprotein phosphatase 1 binding
F0010288biological_processresponse to lead ion
F0016311biological_processdephosphorylation
F0016787molecular_functionhydrolase activity
F0016791molecular_functionphosphatase activity
F0017018molecular_functionmyosin phosphatase activity
F0030324biological_processlung development
F0032922biological_processcircadian regulation of gene expression
F0042587cellular_componentglycogen granule
F0042752biological_processregulation of circadian rhythm
F0043021molecular_functionribonucleoprotein complex binding
F0043025cellular_componentneuronal cell body
F0043153biological_processentrainment of circadian clock by photoperiod
F0043197cellular_componentdendritic spine
F0043204cellular_componentperikaryon
F0043247biological_processtelomere maintenance in response to DNA damage
F0043558biological_processregulation of translational initiation in response to stress
F0044877molecular_functionprotein-containing complex binding
F0045725biological_processpositive regulation of glycogen biosynthetic process
F0046872molecular_functionmetal ion binding
F0046914molecular_functiontransition metal ion binding
F0048754biological_processbranching morphogenesis of an epithelial tube
F0051301biological_processcell division
F0060828biological_processregulation of canonical Wnt signaling pathway
F0070062cellular_componentextracellular exosome
F0072357cellular_componentPTW/PP1 phosphatase complex
F0098609biological_processcell-cell adhesion
F0098641molecular_functioncadherin binding involved in cell-cell adhesion
F0098793cellular_componentpresynapse
F0098794cellular_componentpostsynapse
F0098978cellular_componentglutamatergic synapse
F2001241biological_processpositive regulation of extrinsic apoptotic signaling pathway in absence of ligand
Functional Information from PROSITE/UniProt
site_idPS00125
Number of Residues6
DetailsSER_THR_PHOSPHATASE Serine/threonine specific protein phosphatases signature. LRGNHE
ChainResidueDetails
FLEU121-GLU126

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues6
DetailsBINDING: BINDING => ECO:0000250
ChainResidueDetails
EGLY20
EASP67
EASN126
BGLY20
BASP67
BASN126

site_idSWS_FT_FI2
Number of Residues4
DetailsBINDING: BINDING => ECO:0000250
ChainResidueDetails
FASP64
FHIS66
CASP64
CHIS66

site_idSWS_FT_FI3
Number of Residues8
DetailsBINDING:
ChainResidueDetails
FASP92
FASN124
FHIS173
FHIS248
CASP92
CASN124
CHIS173
CHIS248

site_idSWS_FT_FI4
Number of Residues6
DetailsMOD_RES: Phosphoserine => ECO:0007744|PubMed:23186163
ChainResidueDetails
FSER2
FSER22
FSER325
CSER2
CSER22
CSER325

site_idSWS_FT_FI5
Number of Residues2
DetailsMOD_RES: N6-acetyllysine => ECO:0000250|UniProtKB:P62137
ChainResidueDetails
FLYS305
CLYS305

site_idSWS_FT_FI6
Number of Residues2
DetailsMOD_RES: Phosphotyrosine => ECO:0000250|UniProtKB:P62137
ChainResidueDetails
FTYR306
CTYR306

site_idSWS_FT_FI7
Number of Residues2
DetailsMOD_RES: Phosphothreonine => ECO:0000269|PubMed:16732323, ECO:0007744|PubMed:18088087, ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:20068231, ECO:0007744|PubMed:23186163
ChainResidueDetails
FTHR320
CTHR320

225946

PDB entries from 2024-10-09

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