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7TVF

Crystal structure of the SHOC2-MRAS-PP1CA (SMP) complex to a resolution of 2.17 Angstrom

Functional Information from GO Data
ChainGOidnamespacecontents
A0000164cellular_componentprotein phosphatase type 1 complex
A0005515molecular_functionprotein binding
A0005634cellular_componentnucleus
A0005654cellular_componentnucleoplasm
A0005737cellular_componentcytoplasm
A0005829cellular_componentcytosol
A0008157molecular_functionprotein phosphatase 1 binding
A0008543biological_processfibroblast growth factor receptor signaling pathway
A0010976biological_processpositive regulation of neuron projection development
A0019888molecular_functionprotein phosphatase regulator activity
A0019903molecular_functionprotein phosphatase binding
A0035556biological_processintracellular signal transduction
A0038180biological_processnerve growth factor signaling pathway
A0043408biological_processregulation of MAPK cascade
A0045665biological_processnegative regulation of neuron differentiation
A0045666biological_processpositive regulation of neuron differentiation
A0046579biological_processpositive regulation of Ras protein signal transduction
A0071378biological_processcellular response to growth hormone stimulus
A0140361biological_processcyclic-GMP-AMP transmembrane import across plasma membrane
A2000178biological_processnegative regulation of neural precursor cell proliferation
B0003924molecular_functionGTPase activity
B0005525molecular_functionGTP binding
B0007165biological_processsignal transduction
B0016020cellular_componentmembrane
C0000164cellular_componentprotein phosphatase type 1 complex
C0000723biological_processtelomere maintenance
C0000781cellular_componentchromosome, telomeric region
C0001111biological_processRNA polymerase II promoter clearance
C0004721molecular_functionphosphoprotein phosphatase activity
C0004722molecular_functionprotein serine/threonine phosphatase activity
C0005506molecular_functioniron ion binding
C0005515molecular_functionprotein binding
C0005634cellular_componentnucleus
C0005654cellular_componentnucleoplasm
C0005730cellular_componentnucleolus
C0005737cellular_componentcytoplasm
C0005829cellular_componentcytosol
C0005886cellular_componentplasma membrane
C0005912cellular_componentadherens junction
C0005977biological_processglycogen metabolic process
C0005979biological_processregulation of glycogen biosynthetic process
C0005981biological_processregulation of glycogen catabolic process
C0006366biological_processtranscription by RNA polymerase II
C0006368biological_processtranscription elongation by RNA polymerase II
C0006470biological_processprotein dephosphorylation
C0008157molecular_functionprotein phosphatase 1 binding
C0010288biological_processresponse to lead ion
C0016311biological_processdephosphorylation
C0016787molecular_functionhydrolase activity
C0016791molecular_functionphosphatase activity
C0030324biological_processlung development
C0032922biological_processcircadian regulation of gene expression
C0032968biological_processpositive regulation of transcription elongation by RNA polymerase II
C0034244biological_processnegative regulation of transcription elongation by RNA polymerase II
C0042587cellular_componentglycogen granule
C0042752biological_processregulation of circadian rhythm
C0043021molecular_functionribonucleoprotein complex binding
C0043025cellular_componentneuronal cell body
C0043153biological_processentrainment of circadian clock by photoperiod
C0043197cellular_componentdendritic spine
C0043204cellular_componentperikaryon
C0043247biological_processtelomere maintenance in response to DNA damage
C0043558biological_processregulation of translational initiation in response to stress
C0044877molecular_functionprotein-containing complex binding
C0045725biological_processpositive regulation of glycogen biosynthetic process
C0046872molecular_functionmetal ion binding
C0046914molecular_functiontransition metal ion binding
C0048754biological_processbranching morphogenesis of an epithelial tube
C0050821biological_processprotein stabilization
C0051301biological_processcell division
C0060828biological_processregulation of canonical Wnt signaling pathway
C0070062cellular_componentextracellular exosome
C0072357cellular_componentPTW/PP1 phosphatase complex
C0097681biological_processdouble-strand break repair via alternative nonhomologous end joining
C0098609biological_processcell-cell adhesion
C0098641molecular_functioncadherin binding involved in cell-cell adhesion
C0098793cellular_componentpresynapse
C0098794cellular_componentpostsynapse
C0098978cellular_componentglutamatergic synapse
C0180007molecular_functionRNA polymerase II CTD heptapeptide repeat S5 phosphatase activity
C2000806biological_processpositive regulation of termination of RNA polymerase II transcription, poly(A)-coupled
C2001241biological_processpositive regulation of extrinsic apoptotic signaling pathway in absence of ligand
D0000164cellular_componentprotein phosphatase type 1 complex
D0005515molecular_functionprotein binding
D0005634cellular_componentnucleus
D0005654cellular_componentnucleoplasm
D0005737cellular_componentcytoplasm
D0005829cellular_componentcytosol
D0008157molecular_functionprotein phosphatase 1 binding
D0008543biological_processfibroblast growth factor receptor signaling pathway
D0010976biological_processpositive regulation of neuron projection development
D0019888molecular_functionprotein phosphatase regulator activity
D0019903molecular_functionprotein phosphatase binding
D0035556biological_processintracellular signal transduction
D0038180biological_processnerve growth factor signaling pathway
D0043408biological_processregulation of MAPK cascade
D0045665biological_processnegative regulation of neuron differentiation
D0045666biological_processpositive regulation of neuron differentiation
D0046579biological_processpositive regulation of Ras protein signal transduction
D0071378biological_processcellular response to growth hormone stimulus
D0140361biological_processcyclic-GMP-AMP transmembrane import across plasma membrane
D2000178biological_processnegative regulation of neural precursor cell proliferation
E0003924molecular_functionGTPase activity
E0005525molecular_functionGTP binding
E0007165biological_processsignal transduction
E0016020cellular_componentmembrane
F0000164cellular_componentprotein phosphatase type 1 complex
F0000723biological_processtelomere maintenance
F0000781cellular_componentchromosome, telomeric region
F0001111biological_processRNA polymerase II promoter clearance
F0004721molecular_functionphosphoprotein phosphatase activity
F0004722molecular_functionprotein serine/threonine phosphatase activity
F0005506molecular_functioniron ion binding
F0005515molecular_functionprotein binding
F0005634cellular_componentnucleus
F0005654cellular_componentnucleoplasm
F0005730cellular_componentnucleolus
F0005737cellular_componentcytoplasm
F0005829cellular_componentcytosol
F0005886cellular_componentplasma membrane
F0005912cellular_componentadherens junction
F0005977biological_processglycogen metabolic process
F0005979biological_processregulation of glycogen biosynthetic process
F0005981biological_processregulation of glycogen catabolic process
F0006366biological_processtranscription by RNA polymerase II
F0006368biological_processtranscription elongation by RNA polymerase II
F0006470biological_processprotein dephosphorylation
F0008157molecular_functionprotein phosphatase 1 binding
F0010288biological_processresponse to lead ion
F0016311biological_processdephosphorylation
F0016787molecular_functionhydrolase activity
F0016791molecular_functionphosphatase activity
F0030324biological_processlung development
F0032922biological_processcircadian regulation of gene expression
F0032968biological_processpositive regulation of transcription elongation by RNA polymerase II
F0034244biological_processnegative regulation of transcription elongation by RNA polymerase II
F0042587cellular_componentglycogen granule
F0042752biological_processregulation of circadian rhythm
F0043021molecular_functionribonucleoprotein complex binding
F0043025cellular_componentneuronal cell body
F0043153biological_processentrainment of circadian clock by photoperiod
F0043197cellular_componentdendritic spine
F0043204cellular_componentperikaryon
F0043247biological_processtelomere maintenance in response to DNA damage
F0043558biological_processregulation of translational initiation in response to stress
F0044877molecular_functionprotein-containing complex binding
F0045725biological_processpositive regulation of glycogen biosynthetic process
F0046872molecular_functionmetal ion binding
F0046914molecular_functiontransition metal ion binding
F0048754biological_processbranching morphogenesis of an epithelial tube
F0050821biological_processprotein stabilization
F0051301biological_processcell division
F0060828biological_processregulation of canonical Wnt signaling pathway
F0070062cellular_componentextracellular exosome
F0072357cellular_componentPTW/PP1 phosphatase complex
F0097681biological_processdouble-strand break repair via alternative nonhomologous end joining
F0098609biological_processcell-cell adhesion
F0098641molecular_functioncadherin binding involved in cell-cell adhesion
F0098793cellular_componentpresynapse
F0098794cellular_componentpostsynapse
F0098978cellular_componentglutamatergic synapse
F0180007molecular_functionRNA polymerase II CTD heptapeptide repeat S5 phosphatase activity
F2000806biological_processpositive regulation of termination of RNA polymerase II transcription, poly(A)-coupled
F2001241biological_processpositive regulation of extrinsic apoptotic signaling pathway in absence of ligand
Functional Information from PROSITE/UniProt
site_idPS00125
Number of Residues6
DetailsSER_THR_PHOSPHATASE Serine/threonine specific protein phosphatases signature. LRGNHE
ChainResidueDetails
FLEU121-GLU126

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues38
DetailsBINDING: BINDING => ECO:0000269|PubMed:35831509, ECO:0007744|PDB:7UPI
ChainResidueDetails
EASP21
EPRO40
ETYR42
EPRO44
EGLY70
EASN126
ELYS127
EASP129
ESER156
EALA157
ELYS158
EGLY22
BASP21
BGLY22
BGLY23
BVAL24
BGLY25
BLYS26
BALA28
BPHE38
BVAL39
BPRO40
EGLY23
BTYR42
BPRO44
BGLY70
BASN126
BLYS127
BASP129
BSER156
BALA157
BLYS158
EVAL24
EGLY25
ELYS26
EALA28
EPHE38
EVAL39

site_idSWS_FT_FI2
Number of Residues6
DetailsBINDING: BINDING => ECO:0000269|PubMed:35768504, ECO:0000269|PubMed:35830882, ECO:0000269|PubMed:35831509, ECO:0000269|PubMed:36175670, ECO:0007744|PDB:7SD0, ECO:0007744|PDB:7TVF, ECO:0007744|PDB:7TXH, ECO:0007744|PDB:7UPI
ChainResidueDetails
ESER27
CASN124
CHIS173
CHIS248
ETHR45
EASP67
BSER27
BTHR45
BASP67
CASP64
CHIS66
CASP92

site_idSWS_FT_FI3
Number of Residues6
DetailsMOD_RES: Phosphoserine => ECO:0007744|PubMed:23186163
ChainResidueDetails
FSER2
FSER22
FSER325
CSER2
CSER22
CSER325

site_idSWS_FT_FI4
Number of Residues2
DetailsMOD_RES: N6-acetyllysine => ECO:0000250|UniProtKB:P62137
ChainResidueDetails
FLYS305
CLYS305

site_idSWS_FT_FI5
Number of Residues2
DetailsMOD_RES: Phosphotyrosine => ECO:0000250|UniProtKB:P62137
ChainResidueDetails
FTYR306
CTYR306

site_idSWS_FT_FI6
Number of Residues2
DetailsMOD_RES: Phosphothreonine => ECO:0000269|PubMed:16732323, ECO:0007744|PubMed:18088087, ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:20068231, ECO:0007744|PubMed:23186163
ChainResidueDetails
FTHR320
CTHR320

237423

PDB entries from 2025-06-11

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