7UPI
Cryo-EM structure of SHOC2-PP1c-MRAS holophosphatase complex
Summary for 7UPI
Entry DOI | 10.2210/pdb7upi/pdb |
EMDB information | 26667 |
Descriptor | Ras-related protein M-Ras, Serine/threonine-protein phosphatase PP1-alpha catalytic subunit, Leucine-rich repeat protein SHOC-2, ... (7 entities in total) |
Functional Keywords | shoc2, leucine-rich repeat, mras, protein phosphatase, ras signaling, mapk, cell cycle |
Biological source | Homo sapiens (human) More |
Total number of polymer chains | 3 |
Total formula weight | 124232.74 |
Authors | Fuller, J.R.,Hajian, B.,Lemke, C.,Kwon, J.,Bian, Y.,Aguirre, A. (deposition date: 2022-04-15, release date: 2022-05-04, Last modification date: 2024-06-12) |
Primary citation | Kwon, J.J.,Hajian, B.,Bian, Y.,Young, L.C.,Amor, A.J.,Fuller, J.R.,Fraley, C.V.,Sykes, A.M.,So, J.,Pan, J.,Baker, L.,Lee, S.J.,Wheeler, D.B.,Mayhew, D.L.,Persky, N.S.,Yang, X.,Root, D.E.,Barsotti, A.M.,Stamford, A.W.,Perry, C.K.,Burgin, A.,McCormick, F.,Lemke, C.T.,Hahn, W.C.,Aguirre, A.J. Structure-function analysis of the SHOC2-MRAS-PP1C holophosphatase complex. Nature, 609:408-415, 2022 Cited by PubMed: 35831509DOI: 10.1038/s41586-022-04928-2 PDB entries with the same primary citation |
Experimental method | ELECTRON MICROSCOPY (2.89 Å) |
Structure validation
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