7UPI

Cryo-EM structure of SHOC2-PP1c-MRAS holophosphatase complex

Summary for 7UPI

• Entry DOI: 10.2210/pdb7upi/pdb
• EMDB information: 26667
• Descriptor: Ras-related protein M-Ras, Serine/threonine-protein phosphatase PP1-alpha catalytic subunit, Leucine-rich repeat protein SHOC-2, ... (7 entities in total)
• Functional Keywords: shoc2, leucine-rich repeat, mras, protein phosphatase, ras signaling, mapk, cell cycle
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 3
• Total formula weight: 124232.74

Authors

Fuller, J.R.,Hajian, B.,Lemke, C.,Kwon, J.,Bian, Y.,Aguirre, A. (deposition date: 2022-04-15, release date: 2022-05-04, Last modification date: 2022-09-21)

• Primary citation: Kwon, J.J.,Hajian, B.,Bian, Y.,Young, L.C.,Amor, A.J.,Fuller, J.R.,Fraley, C.V.,Sykes, A.M.,So, J.,Pan, J.,Baker, L.,Lee, S.J.,Wheeler, D.B.,Mayhew, D.L.,Persky, N.S.,Yang, X.,Root, D.E.,Barsotti, A.M.,Stamford, A.W.,Perry, C.K.,Burgin, A.,McCormick, F.,Lemke, C.T.,Hahn, W.C.,Aguirre, A.J.; Structure-function analysis of the SHOC2-MRAS-PP1C holophosphatase complex.; Nature, 609:408-415, 2022; PubMed: 35831509; DOI: 10.1038/s41586-022-04928-2

Experimental method

ELECTRON MICROSCOPY (2.89 Å)