7SD0

Cryo-EM structure of the SHOC2:PP1C:MRAS complex

Summary for 7SD0

• Entry DOI: 10.2210/pdb7sd0/pdb
• EMDB information: 25044
• Descriptor: Leucine-rich repeat protein SHOC-2, Ras-related protein M-Ras, Serine/threonine-protein phosphatase PP1-gamma catalytic subunit, ... (6 entities in total)
• Functional Keywords: phosphatase, leucine rich repeat, raf, complex, signaling protein
• Biological source: Homo sapiens (Human); More
• Total number of polymer chains: 3
• Total formula weight: 127015.88

Authors

Liau, N.P.D.,Johnson, M.C.,Hymowitz, S.G.,Sudhamsu, J. (deposition date: 2021-09-29, release date: 2022-04-20, Last modification date: 2023-11-29)

• Primary citation: Liau, N.P.D.,Johnson, M.C.,Izadi, S.,Gerosa, L.,Hammel, M.,Bruning, J.M.,Wendorff, T.J.,Phung, W.,Hymowitz, S.G.,Sudhamsu, J.; Structural basis for SHOC2 modulation of RAS signalling.; Nature, 609:400-407, 2022; PubMed: 35768504; DOI: 10.1038/s41586-022-04838-3

Experimental method

ELECTRON MICROSCOPY (2.95 Å)