7SD0
Cryo-EM structure of the SHOC2:PP1C:MRAS complex
Summary for 7SD0
Entry DOI | 10.2210/pdb7sd0/pdb |
EMDB information | 25044 |
Descriptor | Leucine-rich repeat protein SHOC-2, Ras-related protein M-Ras, Serine/threonine-protein phosphatase PP1-gamma catalytic subunit, ... (6 entities in total) |
Functional Keywords | phosphatase, leucine rich repeat, raf, complex, signaling protein |
Biological source | Homo sapiens (Human) More |
Total number of polymer chains | 3 |
Total formula weight | 127015.88 |
Authors | Liau, N.P.D.,Johnson, M.C.,Hymowitz, S.G.,Sudhamsu, J. (deposition date: 2021-09-29, release date: 2022-04-20, Last modification date: 2023-11-29) |
Primary citation | Liau, N.P.D.,Johnson, M.C.,Izadi, S.,Gerosa, L.,Hammel, M.,Bruning, J.M.,Wendorff, T.J.,Phung, W.,Hymowitz, S.G.,Sudhamsu, J. Structural basis for SHOC2 modulation of RAS signalling. Nature, 609:400-407, 2022 Cited by PubMed: 35768504DOI: 10.1038/s41586-022-04838-3 PDB entries with the same primary citation |
Experimental method | ELECTRON MICROSCOPY (2.95 Å) |
Structure validation
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