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7SD0

Cryo-EM structure of the SHOC2:PP1C:MRAS complex

Functional Information from GO Data
ChainGOidnamespacecontents
A0000164cellular_componentprotein phosphatase type 1 complex
A0005225molecular_functionvolume-sensitive anion channel activity
A0005515molecular_functionprotein binding
A0005634cellular_componentnucleus
A0005654cellular_componentnucleoplasm
A0005737cellular_componentcytoplasm
A0005829cellular_componentcytosol
A0008157molecular_functionprotein phosphatase 1 binding
A0008543biological_processfibroblast growth factor receptor signaling pathway
A0010976biological_processpositive regulation of neuron projection development
A0019888molecular_functionprotein phosphatase regulator activity
A0019903molecular_functionprotein phosphatase binding
A0035556biological_processintracellular signal transduction
A0038180biological_processnerve growth factor signaling pathway
A0043408biological_processregulation of MAPK cascade
A0045665biological_processnegative regulation of neuron differentiation
A0045666biological_processpositive regulation of neuron differentiation
A0046579biological_processpositive regulation of Ras protein signal transduction
A0071378biological_processcellular response to growth hormone stimulus
A0098656biological_processmonoatomic anion transmembrane transport
A0140361biological_processcyclic-GMP-AMP transmembrane import across plasma membrane
A2000178biological_processnegative regulation of neural precursor cell proliferation
B0000164cellular_componentprotein phosphatase type 1 complex
B0003924molecular_functionGTPase activity
B0003925molecular_functionG protein activity
B0005515molecular_functionprotein binding
B0005525molecular_functionGTP binding
B0005886cellular_componentplasma membrane
B0007165biological_processsignal transduction
B0007265biological_processRas protein signal transduction
B0016020cellular_componentmembrane
B0016787molecular_functionhydrolase activity
B0019003molecular_functionGDP binding
B0030036biological_processactin cytoskeleton organization
B0030742molecular_functionGTP-dependent protein binding
B1990830biological_processcellular response to leukemia inhibitory factor
C0000070biological_processmitotic sister chromatid segregation
C0000165biological_processMAPK cascade
C0000775cellular_componentchromosome, centromeric region
C0000776cellular_componentkinetochore
C0000781cellular_componentchromosome, telomeric region
C0001824biological_processblastocyst development
C0003723molecular_functionRNA binding
C0004721molecular_functionphosphoprotein phosphatase activity
C0004722molecular_functionprotein serine/threonine phosphatase activity
C0005515molecular_functionprotein binding
C0005521molecular_functionlamin binding
C0005634cellular_componentnucleus
C0005654cellular_componentnucleoplasm
C0005694cellular_componentchromosome
C0005730cellular_componentnucleolus
C0005737cellular_componentcytoplasm
C0005739cellular_componentmitochondrion
C0005741cellular_componentmitochondrial outer membrane
C0005815cellular_componentmicrotubule organizing center
C0005829cellular_componentcytosol
C0005856cellular_componentcytoskeleton
C0005925cellular_componentfocal adhesion
C0005977biological_processglycogen metabolic process
C0006338biological_processchromatin remodeling
C0006357biological_processregulation of transcription by RNA polymerase II
C0006470biological_processprotein dephosphorylation
C0007283biological_processspermatogenesis
C0008157molecular_functionprotein phosphatase 1 binding
C0016607cellular_componentnuclear speck
C0016787molecular_functionhydrolase activity
C0016791molecular_functionphosphatase activity
C0017018molecular_functionmyosin phosphatase activity
C0019901molecular_functionprotein kinase binding
C0019903molecular_functionprotein phosphatase binding
C0019904molecular_functionprotein domain specific binding
C0030182biological_processneuron differentiation
C0030496cellular_componentmidbody
C0032154cellular_componentcleavage furrow
C0032922biological_processcircadian regulation of gene expression
C0032991cellular_componentprotein-containing complex
C0033192molecular_functioncalmodulin-dependent protein phosphatase activity
C0042752biological_processregulation of circadian rhythm
C0043153biological_processentrainment of circadian clock by photoperiod
C0043197cellular_componentdendritic spine
C0044877molecular_functionprotein-containing complex binding
C0046822biological_processregulation of nucleocytoplasmic transport
C0046872molecular_functionmetal ion binding
C0048511biological_processrhythmic process
C0051301biological_processcell division
C0060252biological_processpositive regulation of glial cell proliferation
C0072357cellular_componentPTW/PP1 phosphatase complex
C0098793cellular_componentpresynapse
C0098794cellular_componentpostsynapse
C0098978cellular_componentglutamatergic synapse
C0140791molecular_functionhistone H2AXS140 phosphatase activity
C0180004molecular_functionRNA polymerase II CTD heptapeptide repeat Y1 phosphatase activity
C0180005molecular_functionRNA polymerase II CTD heptapeptide repeat T4 phosphatase activity
C0180006molecular_functionRNA polymerase II CTD heptapeptide repeat S2 phosphatase activity
C0180007molecular_functionRNA polymerase II CTD heptapeptide repeat S5 phosphatase activity
C0180008molecular_functionRNA polymerase II CTD heptapeptide repeat S7 phosphatase activity
C1990439molecular_functionMAP kinase serine/threonine phosphatase activity
Functional Information from PROSITE/UniProt
site_idPS00125
Number of Residues6
DetailsSER_THR_PHOSPHATASE Serine/threonine specific protein phosphatases signature. LRGNHE
ChainResidueDetails
CLEU121-GLU126

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues1
DetailsACT_SITE: Proton donor => ECO:0000269|PubMed:7500362
ChainResidueDetails
CHIS125
BPRO40
BTYR42
BPRO44
BGLY70
BASN126
BLYS127
BASP129
BSER156
BALA157
BLYS158
BGLY22
BGLY23
BVAL24
BGLY25
BLYS26
BALA28
BPHE38
BVAL39

site_idSWS_FT_FI2
Number of Residues6
DetailsBINDING: BINDING => ECO:0000269|PubMed:11535607, ECO:0000269|PubMed:15280359, ECO:0000269|PubMed:35768504, ECO:0007744|PDB:1JK7, ECO:0007744|PDB:1U32, ECO:0007744|PDB:7SD0
ChainResidueDetails
CASP64
CHIS66
CASP92
CASN124
CHIS173
CHIS248

site_idSWS_FT_FI3
Number of Residues1
DetailsSITE: Inhibition by microcystin toxin binding
ChainResidueDetails
CCYS273

site_idSWS_FT_FI4
Number of Residues1
DetailsMOD_RES: N-acetylalanine => ECO:0000269|Ref.3, ECO:0000269|Ref.4, ECO:0007744|PubMed:22814378, ECO:0007744|PubMed:25944712
ChainResidueDetails
CALA2

site_idSWS_FT_FI5
Number of Residues1
DetailsMOD_RES: Phosphothreonine => ECO:0007744|PubMed:18669648
ChainResidueDetails
CTHR307

site_idSWS_FT_FI6
Number of Residues1
DetailsMOD_RES: Phosphothreonine => ECO:0007744|PubMed:23186163, ECO:0007744|PubMed:24275569
ChainResidueDetails
CTHR311

229183

PDB entries from 2024-12-18

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