8QXN
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![BU of 8qxn by Molmil](/molmil-images/mine/8qxn) | Cryo-EM structure of tetrameric human SAMHD1 State IV - Depleted relaxed | 分子名称: | 2'-DEOXYADENOSINE 5'-TRIPHOSPHATE, 2'-DEOXYCYTIDINE-5'-TRIPHOSPHATE, Deoxynucleoside triphosphate triphosphohydrolase SAMHD1, ... | 著者 | Acton, O.J, Sheppard, D, Rosenthal, P.B, Taylor, I.A. | 登録日 | 2023-10-24 | 公開日 | 2024-05-15 | 最終更新日 | 2024-05-22 | 実験手法 | ELECTRON MICROSCOPY (2.98 Å) | 主引用文献 | Platform-directed allostery and quaternary structure dynamics of SAMHD1 catalysis. Nat Commun, 15, 2024
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8QXK
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![BU of 8qxk by Molmil](/molmil-images/mine/8qxk) | Cryo-EM structure of tetrameric human SAMHD1 State I - Tense | 分子名称: | 2'-DEOXYADENOSINE 5'-TRIPHOSPHATE, 2'-DEOXYCYTIDINE-5'-TRIPHOSPHATE, Deoxynucleoside triphosphate triphosphohydrolase SAMHD1, ... | 著者 | Acton, O.J, Sheppard, D, Rosenthal, P.B, Taylor, I.A. | 登録日 | 2023-10-24 | 公開日 | 2024-05-15 | 最終更新日 | 2024-05-22 | 実験手法 | ELECTRON MICROSCOPY (2.66 Å) | 主引用文献 | Platform-directed allostery and quaternary structure dynamics of SAMHD1 catalysis. Nat Commun, 15, 2024
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8QXO
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![BU of 8qxo by Molmil](/molmil-images/mine/8qxo) | Cryo-EM structure of tetrameric human SAMHD1 State V - Depleted relaxed | 分子名称: | 2'-DEOXYADENOSINE 5'-TRIPHOSPHATE, 2'-DEOXYCYTIDINE-5'-TRIPHOSPHATE, Deoxynucleoside triphosphate triphosphohydrolase SAMHD1, ... | 著者 | Acton, O.J, Sheppard, D, Rosenthal, P.B, Taylor, I.A. | 登録日 | 2023-10-24 | 公開日 | 2024-05-15 | 最終更新日 | 2024-05-22 | 実験手法 | ELECTRON MICROSCOPY (3.43 Å) | 主引用文献 | Platform-directed allostery and quaternary structure dynamics of SAMHD1 catalysis. Nat Commun, 15, 2024
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8QXL
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![BU of 8qxl by Molmil](/molmil-images/mine/8qxl) | Cryo-EM structure of tetrameric human SAMHD1 State II - Hemi-relaxed | 分子名称: | 2'-DEOXYADENOSINE 5'-TRIPHOSPHATE, 2'-DEOXYCYTIDINE, 2'-DEOXYCYTIDINE-5'-TRIPHOSPHATE, ... | 著者 | Acton, O.J, Sheppard, D, Rosenthal, P.B, Taylor, I.A. | 登録日 | 2023-10-24 | 公開日 | 2024-05-15 | 最終更新日 | 2024-05-22 | 実験手法 | ELECTRON MICROSCOPY (2.82 Å) | 主引用文献 | Platform-directed allostery and quaternary structure dynamics of SAMHD1 catalysis. Nat Commun, 15, 2024
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8QXM
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![BU of 8qxm by Molmil](/molmil-images/mine/8qxm) | Cryo-EM structure of tetrameric human SAMHD1 State III - Relaxed | 分子名称: | 2'-DEOXYADENOSINE 5'-TRIPHOSPHATE, 2'-DEOXYCYTIDINE-5'-TRIPHOSPHATE, Deoxynucleoside triphosphate triphosphohydrolase SAMHD1, ... | 著者 | Acton, O.J, Sheppard, D, Rosenthal, P.B, Taylor, I.A. | 登録日 | 2023-10-24 | 公開日 | 2024-05-15 | 最終更新日 | 2024-05-22 | 実験手法 | ELECTRON MICROSCOPY (2.94 Å) | 主引用文献 | Platform-directed allostery and quaternary structure dynamics of SAMHD1 catalysis. Nat Commun, 15, 2024
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8QXJ
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![BU of 8qxj by Molmil](/molmil-images/mine/8qxj) | Cryo-EM structure of tetrameric human SAMHD1 with dApNHpp | 分子名称: | 2'-deoxy-5'-O-[(R)-hydroxy{[(R)-hydroxy(phosphonooxy)phosphoryl]amino}phosphoryl]adenosine, Deoxynucleoside triphosphate triphosphohydrolase SAMHD1, FE (III) ION, ... | 著者 | Acton, O.J, Sheppard, D, Rosenthal, P.B, Taylor, I.A. | 登録日 | 2023-10-24 | 公開日 | 2024-05-15 | 最終更新日 | 2024-05-22 | 実験手法 | ELECTRON MICROSCOPY (2.65 Å) | 主引用文献 | Platform-directed allostery and quaternary structure dynamics of SAMHD1 catalysis. Nat Commun, 15, 2024
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8TDW
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![BU of 8tdw by Molmil](/molmil-images/mine/8tdw) | ssRNA bound SAMHD1 T open | 分子名称: | Deoxynucleoside triphosphate triphosphohydrolase SAMHD1, FE (III) ION, RNA (5'-R(P*CP*CP*GP*AP*CP*C)-3'), ... | 著者 | Sung, M, Huynh, K, Han, S. | 登録日 | 2023-07-05 | 公開日 | 2023-11-22 | 最終更新日 | 2023-12-20 | 実験手法 | ELECTRON MICROSCOPY (3.04 Å) | 主引用文献 | Guanine-containing ssDNA and RNA induce dimeric and tetrameric structural forms of SAMHD1. Nucleic Acids Res., 51, 2023
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8TDV
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![BU of 8tdv by Molmil](/molmil-images/mine/8tdv) | ssRNA bound SAMHD1 T closed | 分子名称: | Deoxynucleoside triphosphate triphosphohydrolase SAMHD1, FE (III) ION, RNA (5'-R(P*CP*CP*GP*AP*CP*CP*C)-3'), ... | 著者 | Sung, M, Huynh, K, Han, S. | 登録日 | 2023-07-05 | 公開日 | 2023-12-20 | 実験手法 | ELECTRON MICROSCOPY (3.44 Å) | 主引用文献 | Guanine-containing ssDNA and RNA induce dimeric and tetrameric structural forms of SAMHD1. Nucleic Acids Res., 51, 2023
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8P2L
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![BU of 8p2l by Molmil](/molmil-images/mine/8p2l) | |
8P2M
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![BU of 8p2m by Molmil](/molmil-images/mine/8p2m) | C. elegans TIR-1 protein. | 分子名称: | NAD(+) hydrolase tir-1 | 著者 | Isupov, M.N, Opatowsky, Y. | 登録日 | 2023-05-16 | 公開日 | 2023-09-06 | 実験手法 | ELECTRON MICROSCOPY (3.82 Å) | 主引用文献 | Structure-function analysis of ceTIR-1/hSARM1 explains the lack of Wallerian axonal degeneration in C. elegans. Cell Rep, 42, 2023
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8BW9
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![BU of 8bw9 by Molmil](/molmil-images/mine/8bw9) | |
8BW8
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![BU of 8bw8 by Molmil](/molmil-images/mine/8bw8) | |
8GQ5
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![BU of 8gq5 by Molmil](/molmil-images/mine/8gq5) | |
8GNJ
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![BU of 8gnj by Molmil](/molmil-images/mine/8gnj) | |
8GNI
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![BU of 8gni by Molmil](/molmil-images/mine/8gni) | |
8ALY
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![BU of 8aly by Molmil](/molmil-images/mine/8aly) | Cryo-EM structure of human tankyrase 2 SAM-PARP filament (G1032W mutant) | 分子名称: | Poly [ADP-ribose] polymerase tankyrase-2, ZINC ION | 著者 | Mariotti, L, Inian, O, Desfosses, A, Beuron, F, Morris, E.P, Guettler, S. | 登録日 | 2022-08-01 | 公開日 | 2022-11-16 | 最終更新日 | 2022-12-14 | 実験手法 | ELECTRON MICROSCOPY (2.98 Å) | 主引用文献 | Structural basis of tankyrase activation by polymerization. Nature, 612, 2022
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8D9J
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![BU of 8d9j by Molmil](/molmil-images/mine/8d9j) | SAMHD1-DNA complex | 分子名称: | CALCIUM ION, DNA (5'-D(*CP*AP*AP*TP*G)-3'), Deoxynucleoside triphosphate triphosphohydrolase SAMHD1, ... | 著者 | Hollis, T.J, Batalis, S.M. | 登録日 | 2022-06-10 | 公開日 | 2023-07-05 | 最終更新日 | 2023-10-25 | 実験手法 | X-RAY DIFFRACTION (2.82 Å) | 主引用文献 | SAMHD1-DNA complex To Be Published
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8D94
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![BU of 8d94 by Molmil](/molmil-images/mine/8d94) | SAMHD1-DNA complex | 分子名称: | CALCIUM ION, DNA (5'-D(P*TP*GP*T)-3'), Deoxynucleoside triphosphate triphosphohydrolase SAMHD1, ... | 著者 | Hollis, T.J, Batalis, S.M. | 登録日 | 2022-06-09 | 公開日 | 2023-07-05 | 最終更新日 | 2023-10-25 | 実験手法 | X-RAY DIFFRACTION (2.44 Å) | 主引用文献 | SAMHD1-DNA complex To Be Published
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7UJN
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![BU of 7ujn by Molmil](/molmil-images/mine/7ujn) | |
7Z72
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![BU of 7z72 by Molmil](/molmil-images/mine/7z72) | Crystal structure of p63 SAM in complex with darpin A5 | 分子名称: | DI(HYDROXYETHYL)ETHER, Darpin A5, Isoform 9 of Tumor protein 63 | 著者 | Chaikuad, A, Strubel, A, Doetsch, V, Knapp, S, Structural Genomics Consortium (SGC) | 登録日 | 2022-03-14 | 公開日 | 2022-07-06 | 最終更新日 | 2024-01-31 | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | 主引用文献 | Designed Ankyrin Repeat Proteins as a tool box for analyzing p63. Cell Death Differ., 29, 2022
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7QG0
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7NAK
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![BU of 7nak by Molmil](/molmil-images/mine/7nak) | Cryo-EM structure of activated human SARM1 in complex with NMN and 1AD (TIR:1AD) | 分子名称: | NAD(+) hydrolase SARM1, [[(2~{R},3~{S},4~{R},5~{R})-5-(6-aminopurin-9-yl)-3,4-bis(oxidanyl)oxolan-2-yl]methoxy-oxidanyl-phosphoryl] [(2~{R},3~{S},4~{R},5~{R})-5-(5-iodanylisoquinolin-2-yl)-3,4-bis(oxidanyl)oxolan-2-yl]methyl hydrogen phosphate | 著者 | Kerry, P.S, Nanson, J.D, Adams, S, Cunnea, K, Bosanac, T, Kobe, B, Hughes, R.O, Ve, T. | 登録日 | 2021-06-21 | 公開日 | 2022-03-23 | 最終更新日 | 2024-06-05 | 実験手法 | ELECTRON MICROSCOPY (2.9 Å) | 主引用文献 | Structural basis of SARM1 activation, substrate recognition, and inhibition by small molecules. Mol.Cell, 82, 2022
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7NAL
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![BU of 7nal by Molmil](/molmil-images/mine/7nal) | Cryo-EM structure of activated human SARM1 in complex with NMN and 1AD (ARM and SAM domains) | 分子名称: | BETA-NICOTINAMIDE RIBOSE MONOPHOSPHATE, NAD(+) hydrolase SARM1 | 著者 | Kerry, P.S, Nanson, J.D, Adams, S, Cunnea, K, Bosanac, T, Kobe, B, Hughes, R.O, Ve, T. | 登録日 | 2021-06-21 | 公開日 | 2022-03-23 | 最終更新日 | 2024-06-05 | 実験手法 | ELECTRON MICROSCOPY (3 Å) | 主引用文献 | Structural basis of SARM1 activation, substrate recognition, and inhibition by small molecules. Mol.Cell, 82, 2022
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7LD0
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![BU of 7ld0 by Molmil](/molmil-images/mine/7ld0) | Cryo-EM structure of ligand-free Human SARM1 | 分子名称: | NAD(+) hydrolase SARM1 | 著者 | Nanson, J.D, Gu, W, Luo, Z, Jia, X, Landsberg, M.J, Kobe, B, Ve, T. | 登録日 | 2021-01-12 | 公開日 | 2021-03-10 | 最終更新日 | 2024-03-06 | 実験手法 | ELECTRON MICROSCOPY (3.1 Å) | 主引用文献 | SARM1 is a metabolic sensor activated by an increased NMN/NAD + ratio to trigger axon degeneration. Neuron, 109, 2021
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7DJT
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![BU of 7djt by Molmil](/molmil-images/mine/7djt) | Human SARM1 inhibitory state bounded with inhibitor dHNN | 分子名称: | NAD(+) hydrolase SARM1, O3-methyl O5-(2-methylpropyl) 2,6-dimethyl-4-[2-(oxidanylamino)phenyl]pyridine-3,5-dicarboxylate | 著者 | Cai, Y, Zhang, H. | 登録日 | 2020-11-21 | 公開日 | 2021-05-19 | 最終更新日 | 2023-11-15 | 実験手法 | ELECTRON MICROSCOPY (2.8 Å) | 主引用文献 | Permeant fluorescent probes visualize the activation of SARM1 and uncover an anti-neurodegenerative drug candidate. Elife, 10, 2021
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