8BW8
Crystal structure of the dCNK-SAM-CRIC-PDZ/dHYP-SAM complex
Summary for 8BW8
Entry DOI | 10.2210/pdb8bw8/pdb |
Related | 8BW9 |
EMDB information | 16281 |
Descriptor | Protein aveugle, Connector enhancer of KSR protein CNK, GLYCEROL, ... (4 entities in total) |
Functional Keywords | scaffolding protein, connector enhancer of ksr (cnk), protein aveugle (ave), hyphen protein (hyp), complex protein, sterile alpha motif (sam) domain, conserved region in cnk (cric) domain, psd-95, dlg, and zo-1. (pdz) domain., signaling protein |
Biological source | Drosophila melanogaster (fruit fly) More |
Total number of polymer chains | 6 |
Total formula weight | 155863.19 |
Authors | Maisonneuve, P.,Kurinov, I.,Sicheri, F. (deposition date: 2022-12-06, release date: 2024-02-21, Last modification date: 2024-07-31) |
Primary citation | Maisonneuve, P.,Sahmi, M.,Bergeron-Labrecque, F.,Ma, X.I.,Queguiner, J.,Arseneault, G.,Lefrancois, M.,Kurinov, I.,Fronzes, R.,Sicheri, F.,Therrien, M. The CNK-HYP scaffolding complex promotes RAF activation by enhancing KSR-MEK interaction. Nat.Struct.Mol.Biol., 31:1028-1038, 2024 Cited by PubMed: 38388830DOI: 10.1038/s41594-024-01233-6 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.1 Å) |
Structure validation
Download full validation report![Download](/newweb/media/icons/dl.png)
![Download](/newweb/media/icons/dl.png)