8BW8

Crystal structure of the dCNK-SAM-CRIC-PDZ/dHYP-SAM complex

Summary for 8BW8

• Entry DOI: 10.2210/pdb8bw8/pdb
• Related: 8BW9
• EMDB information: 16281
• Descriptor: Protein aveugle, Connector enhancer of KSR protein CNK, GLYCEROL, ... (4 entities in total)
• Functional Keywords: scaffolding protein, connector enhancer of ksr (cnk), protein aveugle (ave), hyphen protein (hyp), complex protein, sterile alpha motif (sam) domain, conserved region in cnk (cric) domain, psd-95, dlg, and zo-1. (pdz) domain., signaling protein
• Biological source: Drosophila melanogaster (fruit fly); More
• Total number of polymer chains: 6
• Total formula weight: 155863.19

Authors

Maisonneuve, P.,Kurinov, I.,Sicheri, F. (deposition date: 2022-12-06, release date: 2024-02-21, Last modification date: 2024-03-06)

• Primary citation: Maisonneuve, P.,Sahmi, M.,Bergeron-Labrecque, F.,Ma, X.I.,Queguiner, J.,Arseneault, G.,Lefrancois, M.,Kurinov, I.,Fronzes, R.,Sicheri, F.,Therrien, M.; The CNK-HYP scaffolding complex promotes RAF activation by enhancing KSR-MEK interaction.; Nat.Struct.Mol.Biol., 2024; PubMed: 38388830; DOI: 10.1038/s41594-024-01233-6

Experimental method

X-RAY DIFFRACTION (2.1 Å)