8BW9

Cryo-EM structure of the RAF activating complex KSR-MEK-CNK-HYP

Summary for 8BW9

• Entry DOI: 10.2210/pdb8bw9/pdb
• Related: 8BW8
• EMDB information: 16281
• Descriptor: Protein aveugle, Connector enhancer of KSR protein CNK, Dual specificity mitogen-activated protein kinase kinase dSOR1, ... (7 entities in total)
• Functional Keywords: kinase suppressor of ras (ksr), dual specificity mitogen-activated protein kinase kinase (mek), connector enhancer of ksr (cnk), protein aveugle (ave), hyphen protein (hyp), protein complex, signaling protein
• Biological source: Drosophila melanogaster (fruit fly); More
• Total number of polymer chains: 4
• Total formula weight: 133225.40

Authors

Maisonneuve, P.,Fronzes, R.,Sicheri, F. (deposition date: 2022-12-06, release date: 2024-02-21, Last modification date: 2024-03-06)

• Primary citation: Maisonneuve, P.,Sahmi, M.,Bergeron-Labrecque, F.,Ma, X.I.,Queguiner, J.,Arseneault, G.,Lefrancois, M.,Kurinov, I.,Fronzes, R.,Sicheri, F.,Therrien, M.; The CNK-HYP scaffolding complex promotes RAF activation by enhancing KSR-MEK interaction.; Nat.Struct.Mol.Biol., 2024; PubMed: 38388830; DOI: 10.1038/s41594-024-01233-6

Experimental method

ELECTRON MICROSCOPY (3.32 Å)