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8BW9

Cryo-EM structure of the RAF activating complex KSR-MEK-CNK-HYP

Functional Information from GO Data
ChainGOidnamespacecontents
A0001751biological_processcompound eye photoreceptor cell differentiation
A0001754biological_processeye photoreceptor cell differentiation
A0003674molecular_functionmolecular_function
A0005515molecular_functionprotein binding
A0005737cellular_componentcytoplasm
A0005829cellular_componentcytosol
A0007169biological_processcell surface receptor protein tyrosine kinase signaling pathway
A0007173biological_processepidermal growth factor receptor signaling pathway
A0007601biological_processvisual perception
A0009898cellular_componentcytoplasmic side of plasma membrane
A0016020cellular_componentmembrane
A0042675biological_processcompound eye cone cell differentiation
A0046579biological_processpositive regulation of Ras protein signal transduction
A0070374biological_processpositive regulation of ERK1 and ERK2 cascade
A0097110molecular_functionscaffold protein binding
C0000165biological_processMAPK cascade
C0000793cellular_componentcondensed chromosome
C0004672molecular_functionprotein kinase activity
C0004674molecular_functionprotein serine/threonine kinase activity
C0004708molecular_functionMAP kinase kinase activity
C0004712molecular_functionprotein serine/threonine/tyrosine kinase activity
C0004713molecular_functionprotein tyrosine kinase activity
C0005515molecular_functionprotein binding
C0005524molecular_functionATP binding
C0005635cellular_componentnuclear envelope
C0005829cellular_componentcytosol
C0006468biological_processprotein phosphorylation
C0007095biological_processmitotic G2 DNA damage checkpoint signaling
C0007173biological_processepidermal growth factor receptor signaling pathway
C0007298biological_processborder follicle cell migration
C0007362biological_processterminal region determination
C0007430biological_processterminal branching, open tracheal system
C0007465biological_processR7 cell fate commitment
C0008286biological_processinsulin receptor signaling pathway
C0008293biological_processtorso signaling pathway
C0008340biological_processdetermination of adult lifespan
C0008543biological_processfibroblast growth factor receptor signaling pathway
C0009953biological_processdorsal/ventral pattern formation
C0016310biological_processphosphorylation
C0019900molecular_functionkinase binding
C0033314biological_processmitotic DNA replication checkpoint signaling
C0042386biological_processhemocyte differentiation
C0042461biological_processphotoreceptor cell development
C0045500biological_processsevenless signaling pathway
C0048010biological_processvascular endothelial growth factor receptor signaling pathway
C0051607biological_processdefense response to virus
C0070371biological_processERK1 and ERK2 cascade
C0071481biological_processcellular response to X-ray
C0106310molecular_functionprotein serine kinase activity
D0004672molecular_functionprotein kinase activity
D0005524molecular_functionATP binding
D0006468biological_processprotein phosphorylation
Functional Information from PROSITE/UniProt
site_idPS00107
Number of Residues24
DetailsPROTEIN_KINASE_ATP Protein kinases ATP-binding region signature. LGSGNGGVVMkVrhththli..........MARK
ChainResidueDetails
CLEU93-LYS116
DILE685-LYS705

site_idPS00108
Number of Residues13
DetailsPROTEIN_KINASE_ST Serine/Threonine protein kinases active-site signature. IiHrDVKpsNILV
ChainResidueDetails
CILE205-VAL217

site_idPS00109
Number of Residues13
DetailsPROTEIN_KINASE_TYR Tyrosine protein kinases specific active-site signature. IIHkDLRTKNIFI
ChainResidueDetails
DILE796-ILE808

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues1
DetailsACT_SITE: Proton acceptor => ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000255|PROSITE-ProRule:PRU10027
ChainResidueDetails
CASP209

site_idSWS_FT_FI2
Number of Residues2
DetailsBINDING: BINDING => ECO:0000255|PROSITE-ProRule:PRU00159
ChainResidueDetails
CLEU93
CLYS116

site_idSWS_FT_FI3
Number of Residues2
DetailsMOD_RES: Phosphoserine; by RAF => ECO:0000269|PubMed:29433126
ChainResidueDetails
CSER237
CSER241

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PDB entries from 2024-10-16

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