8BW9

Cryo-EM structure of the RAF activating complex KSR-MEK-CNK-HYP

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0001751	biological_process	compound eye photoreceptor cell differentiation
A	0001754	biological_process	eye photoreceptor cell differentiation
A	0005515	molecular_function	protein binding
A	0005737	cellular_component	cytoplasm
A	0005829	cellular_component	cytosol
A	0007169	biological_process	cell surface receptor protein tyrosine kinase signaling pathway
A	0007173	biological_process	epidermal growth factor receptor signaling pathway
A	0007601	biological_process	visual perception
A	0009898	cellular_component	cytoplasmic side of plasma membrane
A	0016020	cellular_component	membrane
A	0042675	biological_process	compound eye cone cell differentiation
A	0046579	biological_process	positive regulation of Ras protein signal transduction
A	0070374	biological_process	positive regulation of ERK1 and ERK2 cascade
A	0097110	molecular_function	scaffold protein binding
C	0000165	biological_process	MAPK cascade
C	0000166	molecular_function	nucleotide binding
C	0000793	cellular_component	condensed chromosome
C	0004672	molecular_function	protein kinase activity
C	0004674	molecular_function	protein serine/threonine kinase activity
C	0004708	molecular_function	MAP kinase kinase activity
C	0004713	molecular_function	protein tyrosine kinase activity
C	0005515	molecular_function	protein binding
C	0005524	molecular_function	ATP binding
C	0005635	cellular_component	nuclear envelope
C	0005829	cellular_component	cytosol
C	0006468	biological_process	protein phosphorylation
C	0007095	biological_process	mitotic G2 DNA damage checkpoint signaling
C	0007173	biological_process	epidermal growth factor receptor signaling pathway
C	0007298	biological_process	border follicle cell migration
C	0007362	biological_process	terminal region determination
C	0007430	biological_process	terminal branching, open tracheal system
C	0007465	biological_process	R7 cell fate commitment
C	0008286	biological_process	insulin receptor signaling pathway
C	0008293	biological_process	torso signaling pathway
C	0008340	biological_process	determination of adult lifespan
C	0008543	biological_process	fibroblast growth factor receptor signaling pathway
C	0009953	biological_process	dorsal/ventral pattern formation
C	0016301	molecular_function	kinase activity
C	0016740	molecular_function	transferase activity
C	0019900	molecular_function	kinase binding
C	0033314	biological_process	mitotic DNA replication checkpoint signaling
C	0042386	biological_process	hemocyte differentiation
C	0042461	biological_process	photoreceptor cell development
C	0045500	biological_process	sevenless signaling pathway
C	0048010	biological_process	vascular endothelial growth factor receptor signaling pathway
C	0051607	biological_process	defense response to virus
C	0070371	biological_process	ERK1 and ERK2 cascade
C	0071481	biological_process	cellular response to X-ray
C	0106310	molecular_function	protein serine kinase activity
D	0004672	molecular_function	protein kinase activity
D	0005524	molecular_function	ATP binding
D	0006468	biological_process	protein phosphorylation

Functional Information from PROSITE/UniProt

site_id	PS00108
Number of Residues	13
Details	PROTEIN_KINASE_ST Serine/Threonine protein kinases active-site signature. IiHrDVKpsNILV

Chain	Residue	Details
C	ILE205-VAL217

---

site_id	PS00109
Number of Residues	13
Details	PROTEIN_KINASE_TYR Tyrosine protein kinases specific active-site signature. IIHkDLRTKNIFI

Chain	Residue	Details
D	ILE796-ILE808

---

site_id	PS00107
Number of Residues	21
Details	PROTEIN_KINASE_ATP Protein kinases ATP-binding region signature. IGQGRFGTVHrAlwhgd.............VAVK

Chain	Residue	Details
D	ILE685-LYS705
C	LEU93-LYS116

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	65
Details	Domain: {"description":"SAM","evidences":[{"source":"PROSITE-ProRule","id":"PRU00184","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	1
Details	Active site: {"description":"Proton acceptor","evidences":[{"source":"PROSITE-ProRule","id":"PRU00159","evidenceCode":"ECO:0000255"},{"source":"PROSITE-ProRule","id":"PRU10027","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	9
Details	Binding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU00159","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	2
Details	Modified residue: {"description":"Phosphoserine; by RAF","evidences":[{"source":"PubMed","id":"29433126","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---