8QXK

Cryo-EM structure of tetrameric human SAMHD1 State I - Tense

Summary for 8QXK

Entry DOI	10.2210/pdb8qxk/pdb
EMDB information	18730
Descriptor	Deoxynucleoside triphosphate triphosphohydrolase SAMHD1, GUANOSINE-5'-TRIPHOSPHATE, FE (III) ION, ... (6 entities in total)
Functional Keywords	triphosphohydrolase, metallo-enzyme, binuclear, hd, hydrolase
Biological source	Homo sapiens (human)
Total number of polymer chains	4
Total formula weight	295662.77
Authors	Acton, O.J.,Sheppard, D.,Rosenthal, P.B.,Taylor, I.A. (deposition date: 2023-10-24, release date: 2024-05-15, Last modification date: 2024-05-22)
Primary citation	Acton, O.J.,Sheppard, D.,Kunzelmann, S.,Caswell, S.J.,Nans, A.,Burgess, A.J.O.,Kelly, G.,Morris, E.R.,Rosenthal, P.B.,Taylor, I.A. Platform-directed allostery and quaternary structure dynamics of SAMHD1 catalysis. Nat Commun, 15:3775-3775, 2024 Cited by PubMed: 38710701 DOI: 10.1038/s41467-024-48237-w PDB entries with the same primary citation
Experimental method	ELECTRON MICROSCOPY (2.66 Å)

Structure validation