8QXK

Cryo-EM structure of tetrameric human SAMHD1 State I - Tense

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, C, B, D	Deoxynucleoside triphosphate triphosphohydrolase SAMHD1	polymer	626	72305.4	4	UniProt (Q9Y3Z3) Pfam (PF07647) Pfam (PF01966) In PDB	Homo sapiens (human)
2	D, A, C, B	GUANOSINE-5'-TRIPHOSPHATE	non-polymer		523.2	4	Chemie (GTP)
3	D, A, C, B	FE (III) ION	non-polymer		55.8	4	Chemie (FE)
4	D, A, C, B	MAGNESIUM ION	non-polymer		24.3	12	Chemie (MG)
5	D, A, C, B	2'-DEOXYCYTIDINE-5'-TRIPHOSPHATE	non-polymer		467.2	4	Chemie (DCP)
6	A, C, B, D	2'-DEOXYADENOSINE 5'-TRIPHOSPHATE	non-polymer		491.2	4	Chemie (DTP)

Contents of the asymmetric unit

Polymers	Number of chains	4
	Total formula weight	289221.7
Non-Polymers*	Number of molecules	28
	Total formula weight	6441.1
All*	Total formula weight	295662.8

*Water molecules are not included.