8QXK

Cryo-EM structure of tetrameric human SAMHD1 State I - Tense

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B, C, D (A, C, B, D)	Deoxynucleoside triphosphate triphosphohydrolase SAMHD1	polymer	626	72305.4	4	UniProt (Q9Y3Z3) Pfam (PF07647) Pfam (PF01966)	Homo sapiens (human)
2	AA, E, L, T (D, A, C, B)	GUANOSINE-5'-TRIPHOSPHATE	non-polymer		523.2	4	Chemie (GTP) PubChem (177679032) PubChem (135400627) PubChem (135487750) PubChem (136088935) PubChem (136803486) PubChem (135398633) PubChem (135544356) PubChem (135547949) PubChem (135600366) PubChem (135749822) PubChem (136005188) PubChem (136073923) PubChem (136240914) PubChem (136664747) PubChem (136772743) PubChem (136772744) PubChem (136803487) PubChem (137286749) PubChem (164715984) PubChem (171699466)
3	BA, F, M, U (D, A, C, B)	FE (III) ION	non-polymer		55.8	4	Chemie (FE) PubChem (29936)
4	CA, DA, EA, G, H... (D, A, C, B)	MAGNESIUM ION	non-polymer		24.3	12	Chemie (MG) PubChem (888)
5	FA, J, Q, Y (D, A, C, B)	2'-DEOXYCYTIDINE-5'-TRIPHOSPHATE	non-polymer		467.2	4	Chemie (DCP) PubChem (44119993) PubChem (46936621) PubChem (53393445) PubChem (625) PubChem (57187895) PubChem (65091) PubChem (92436637) PubChem (92449132) PubChem (92449133) PubChem (472334) PubChem (121522025) PubChem (171699322) PubChem (129069886)
6	K, R, S, Z (A, C, B, D)	2'-DEOXYADENOSINE 5'-TRIPHOSPHATE	non-polymer		491.2	4	Chemie (DTP) PubChem (44119995) PubChem (46936612) PubChem (57233913) PubChem (89346292) PubChem (622) PubChem (15993) PubChem (91632917) PubChem (92341128) PubChem (92449119) PubChem (92449120) PubChem (448808) PubChem (129069956) PubChem (171699368)

Contents of the asymmetric unit

Polymers	Number of chains	4
	Total formula weight	289221.7
Non-Polymers*	Number of molecules	28
	Total formula weight	6441.1
All*	Total formula weight	295662.8

*Water molecules are not included.