7NAL

Cryo-EM structure of activated human SARM1 in complex with NMN and 1AD (ARM and SAM domains)

Summary for 7NAL

• Entry DOI: 10.2210/pdb7nal/pdb
• EMDB information: 24273
• Descriptor: NAD(+) hydrolase SARM1, BETA-NICOTINAMIDE RIBOSE MONOPHOSPHATE (2 entities in total)
• Functional Keywords: nadase, axon degeneration, inhibitor, complex, hydrolase
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 8
• Total formula weight: 614453.57

Authors

Kerry, P.S.,Nanson, J.D.,Adams, S.,Cunnea, K.,Bosanac, T.,Kobe, B.,Hughes, R.O.,Ve, T. (deposition date: 2021-06-21, release date: 2022-03-23, Last modification date: 2022-05-18)

• Primary citation: Shi, Y.,Kerry, P.S.,Nanson, J.D.,Bosanac, T.,Sasaki, Y.,Krauss, R.,Saikot, F.K.,Adams, S.E.,Mosaiab, T.,Masic, V.,Mao, X.,Rose, F.,Vasquez, E.,Furrer, M.,Cunnea, K.,Brearley, A.,Gu, W.,Luo, Z.,Brillault, L.,Landsberg, M.J.,DiAntonio, A.,Kobe, B.,Milbrandt, J.,Hughes, R.O.,Ve, T.; Structural basis of SARM1 activation, substrate recognition, and inhibition by small molecules.; Mol.Cell, 82:1643-, 2022; PubMed: 35334231; DOI: 10.1016/j.molcel.2022.03.007

Experimental method

ELECTRON MICROSCOPY (3 Å)