7UJN

Structure of Human SAMHD1 with Non-Hydrolysable dGTP Analog

Summary for 7UJN

Entry DOI	10.2210/pdb7ujn/pdb
EMDB information	26567
Descriptor	Deoxynucleoside triphosphate triphosphohydrolase SAMHD1, 2'-deoxyguanosine-5'-O-(1-thiotriphosphate) (2 entities in total)
Functional Keywords	dntp triphosphatase, hydrolase
Biological source	Homo sapiens (human)
Total number of polymer chains	4
Total formula weight	295500.62
Authors	Huynh, K.W.,Ammirati, M.,Han, S. (deposition date: 2022-03-31, release date: 2022-07-20, Last modification date: 2024-02-14)
Primary citation	Orris, B.,Huynh, K.W.,Ammirati, M.,Han, S.,Bolanos, B.,Carmody, J.,Petroski, M.D.,Bosbach, B.,Shields, D.J.,Stivers, J.T. Phosphorylation of SAMHD1 Thr592 increases C-terminal domain dynamics, tetramer dissociation and ssDNA binding kinetics. Nucleic Acids Res., 50:7545-7559, 2022 Cited by PubMed: 35801923 DOI: 10.1093/nar/gkac573 PDB entries with the same primary citation
Experimental method	ELECTRON MICROSCOPY (2.89 Å)

Structure validation