7DJT

Human SARM1 inhibitory state bounded with inhibitor dHNN

Summary for 7DJT

• Entry DOI: 10.2210/pdb7djt/pdb
• EMDB information: 30700
• Descriptor: NAD(+) hydrolase SARM1, O3-methyl O5-(2-methylpropyl) 2,6-dimethyl-4-[2-(oxidanylamino)phenyl]pyridine-3,5-dicarboxylate (2 entities in total)
• Functional Keywords: nad(+) hydrolase, hydrolase
• Biological source: Homo sapiens (human)
• Total number of polymer chains: 8
• Total formula weight: 616256.57

Authors

Cai, Y.,Zhang, H. (deposition date: 2020-11-21, release date: 2021-05-19, Last modification date: 2023-11-15)

• Primary citation: Li, W.H.,Huang, K.,Cai, Y.,Wang, Q.W.,Zhu, W.J.,Hou, Y.N.,Wang, S.,Cao, S.,Zhao, Z.Y.,Xie, X.J.,Du, Y.,Lee, C.S.,Lee, H.C.,Zhang, H.,Zhao, Y.J.; Permeant fluorescent probes visualize the activation of SARM1 and uncover an anti-neurodegenerative drug candidate.; Elife, 10:-, 2021; PubMed: 33944777; DOI: 10.7554/eLife.67381

Experimental method

ELECTRON MICROSCOPY (2.8 Å)