7LD0
Cryo-EM structure of ligand-free Human SARM1
Summary for 7LD0
Entry DOI | 10.2210/pdb7ld0/pdb |
EMDB information | 23278 |
Descriptor | NAD(+) hydrolase SARM1 (1 entity in total) |
Functional Keywords | nadase, autoinhibition, neurodegeneration, allostery, nad, toxin, hydrolase, signaling protein |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 8 |
Total formula weight | 611771.75 |
Authors | Nanson, J.D.,Gu, W.,Luo, Z.,Jia, X.,Landsberg, M.J.,Kobe, B.,Ve, T. (deposition date: 2021-01-12, release date: 2021-03-10, Last modification date: 2024-03-06) |
Primary citation | Figley, M.D.,Gu, W.,Nanson, J.D.,Shi, Y.,Sasaki, Y.,Cunnea, K.,Malde, A.K.,Jia, X.,Luo, Z.,Saikot, F.K.,Mosaiab, T.,Masic, V.,Holt, S.,Hartley-Tassell, L.,McGuinness, H.Y.,Manik, M.K.,Bosanac, T.,Landsberg, M.J.,Kerry, P.S.,Mobli, M.,Hughes, R.O.,Milbrandt, J.,Kobe, B.,DiAntonio, A.,Ve, T. SARM1 is a metabolic sensor activated by an increased NMN/NAD + ratio to trigger axon degeneration. Neuron, 109:1118-, 2021 Cited by PubMed: 33657413DOI: 10.1016/j.neuron.2021.02.009 PDB entries with the same primary citation |
Experimental method | ELECTRON MICROSCOPY (3.1 Å) |
Structure validation
Download full validation report