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7LD0

Cryo-EM structure of ligand-free Human SARM1

Functional Information from GO Data
ChainGOidnamespacecontents
A0002376biological_processimmune system process
A0003953molecular_functionNAD+ nucleosidase activity
A0005515molecular_functionprotein binding
A0005737cellular_componentcytoplasm
A0005739cellular_componentmitochondrion
A0005741cellular_componentmitochondrial outer membrane
A0005829cellular_componentcytosol
A0005874cellular_componentmicrotubule
A0007165biological_processsignal transduction
A0007399biological_processnervous system development
A0009749biological_processresponse to glucose
A0009986cellular_componentcell surface
A0015630cellular_componentmicrotubule cytoskeleton
A0016787molecular_functionhydrolase activity
A0019677biological_processNAD+ catabolic process
A0030154biological_processcell differentiation
A0030424cellular_componentaxon
A0030425cellular_componentdendrite
A0031594cellular_componentneuromuscular junction
A0032991cellular_componentprotein-containing complex
A0034128biological_processnegative regulation of MyD88-independent toll-like receptor signaling pathway
A0035591molecular_functionsignaling adaptor activity
A0042995cellular_componentcell projection
A0043523biological_processregulation of neuron apoptotic process
A0045087biological_processinnate immune response
A0045202cellular_componentsynapse
A0048678biological_processresponse to axon injury
A0048814biological_processregulation of dendrite morphogenesis
A0050135molecular_functionNADP+ nucleosidase activity
A0050877biological_processnervous system process
A0061809molecular_functionNAD+ nucleosidase activity, cyclic ADP-ribose generating
A0070585biological_processprotein localization to mitochondrion
A0098978cellular_componentglutamatergic synapse
A0099010biological_processmodification of postsynaptic structure
A0099243cellular_componentextrinsic component of synaptic membrane
A1905806biological_processregulation of synapse pruning
B0002376biological_processimmune system process
B0003953molecular_functionNAD+ nucleosidase activity
B0005515molecular_functionprotein binding
B0005737cellular_componentcytoplasm
B0005739cellular_componentmitochondrion
B0005741cellular_componentmitochondrial outer membrane
B0005829cellular_componentcytosol
B0005874cellular_componentmicrotubule
B0007165biological_processsignal transduction
B0007399biological_processnervous system development
B0009749biological_processresponse to glucose
B0009986cellular_componentcell surface
B0015630cellular_componentmicrotubule cytoskeleton
B0016787molecular_functionhydrolase activity
B0019677biological_processNAD+ catabolic process
B0030154biological_processcell differentiation
B0030424cellular_componentaxon
B0030425cellular_componentdendrite
B0031594cellular_componentneuromuscular junction
B0032991cellular_componentprotein-containing complex
B0034128biological_processnegative regulation of MyD88-independent toll-like receptor signaling pathway
B0035591molecular_functionsignaling adaptor activity
B0042995cellular_componentcell projection
B0043523biological_processregulation of neuron apoptotic process
B0045087biological_processinnate immune response
B0045202cellular_componentsynapse
B0048678biological_processresponse to axon injury
B0048814biological_processregulation of dendrite morphogenesis
B0050135molecular_functionNADP+ nucleosidase activity
B0050877biological_processnervous system process
B0061809molecular_functionNAD+ nucleosidase activity, cyclic ADP-ribose generating
B0070585biological_processprotein localization to mitochondrion
B0098978cellular_componentglutamatergic synapse
B0099010biological_processmodification of postsynaptic structure
B0099243cellular_componentextrinsic component of synaptic membrane
B1905806biological_processregulation of synapse pruning
C0002376biological_processimmune system process
C0003953molecular_functionNAD+ nucleosidase activity
C0005515molecular_functionprotein binding
C0005737cellular_componentcytoplasm
C0005739cellular_componentmitochondrion
C0005741cellular_componentmitochondrial outer membrane
C0005829cellular_componentcytosol
C0005874cellular_componentmicrotubule
C0007165biological_processsignal transduction
C0007399biological_processnervous system development
C0009749biological_processresponse to glucose
C0009986cellular_componentcell surface
C0015630cellular_componentmicrotubule cytoskeleton
C0016787molecular_functionhydrolase activity
C0019677biological_processNAD+ catabolic process
C0030154biological_processcell differentiation
C0030424cellular_componentaxon
C0030425cellular_componentdendrite
C0031594cellular_componentneuromuscular junction
C0032991cellular_componentprotein-containing complex
C0034128biological_processnegative regulation of MyD88-independent toll-like receptor signaling pathway
C0035591molecular_functionsignaling adaptor activity
C0042995cellular_componentcell projection
C0043523biological_processregulation of neuron apoptotic process
C0045087biological_processinnate immune response
C0045202cellular_componentsynapse
C0048678biological_processresponse to axon injury
C0048814biological_processregulation of dendrite morphogenesis
C0050135molecular_functionNADP+ nucleosidase activity
C0050877biological_processnervous system process
C0061809molecular_functionNAD+ nucleosidase activity, cyclic ADP-ribose generating
C0070585biological_processprotein localization to mitochondrion
C0098978cellular_componentglutamatergic synapse
C0099010biological_processmodification of postsynaptic structure
C0099243cellular_componentextrinsic component of synaptic membrane
C1905806biological_processregulation of synapse pruning
D0002376biological_processimmune system process
D0003953molecular_functionNAD+ nucleosidase activity
D0005515molecular_functionprotein binding
D0005737cellular_componentcytoplasm
D0005739cellular_componentmitochondrion
D0005741cellular_componentmitochondrial outer membrane
D0005829cellular_componentcytosol
D0005874cellular_componentmicrotubule
D0007165biological_processsignal transduction
D0007399biological_processnervous system development
D0009749biological_processresponse to glucose
D0009986cellular_componentcell surface
D0015630cellular_componentmicrotubule cytoskeleton
D0016787molecular_functionhydrolase activity
D0019677biological_processNAD+ catabolic process
D0030154biological_processcell differentiation
D0030424cellular_componentaxon
D0030425cellular_componentdendrite
D0031594cellular_componentneuromuscular junction
D0032991cellular_componentprotein-containing complex
D0034128biological_processnegative regulation of MyD88-independent toll-like receptor signaling pathway
D0035591molecular_functionsignaling adaptor activity
D0042995cellular_componentcell projection
D0043523biological_processregulation of neuron apoptotic process
D0045087biological_processinnate immune response
D0045202cellular_componentsynapse
D0048678biological_processresponse to axon injury
D0048814biological_processregulation of dendrite morphogenesis
D0050135molecular_functionNADP+ nucleosidase activity
D0050877biological_processnervous system process
D0061809molecular_functionNAD+ nucleosidase activity, cyclic ADP-ribose generating
D0070585biological_processprotein localization to mitochondrion
D0098978cellular_componentglutamatergic synapse
D0099010biological_processmodification of postsynaptic structure
D0099243cellular_componentextrinsic component of synaptic membrane
D1905806biological_processregulation of synapse pruning
E0002376biological_processimmune system process
E0003953molecular_functionNAD+ nucleosidase activity
E0005515molecular_functionprotein binding
E0005737cellular_componentcytoplasm
E0005739cellular_componentmitochondrion
E0005741cellular_componentmitochondrial outer membrane
E0005829cellular_componentcytosol
E0005874cellular_componentmicrotubule
E0007165biological_processsignal transduction
E0007399biological_processnervous system development
E0009749biological_processresponse to glucose
E0009986cellular_componentcell surface
E0015630cellular_componentmicrotubule cytoskeleton
E0016787molecular_functionhydrolase activity
E0019677biological_processNAD+ catabolic process
E0030154biological_processcell differentiation
E0030424cellular_componentaxon
E0030425cellular_componentdendrite
E0031594cellular_componentneuromuscular junction
E0032991cellular_componentprotein-containing complex
E0034128biological_processnegative regulation of MyD88-independent toll-like receptor signaling pathway
E0035591molecular_functionsignaling adaptor activity
E0042995cellular_componentcell projection
E0043523biological_processregulation of neuron apoptotic process
E0045087biological_processinnate immune response
E0045202cellular_componentsynapse
E0048678biological_processresponse to axon injury
E0048814biological_processregulation of dendrite morphogenesis
E0050135molecular_functionNADP+ nucleosidase activity
E0050877biological_processnervous system process
E0061809molecular_functionNAD+ nucleosidase activity, cyclic ADP-ribose generating
E0070585biological_processprotein localization to mitochondrion
E0098978cellular_componentglutamatergic synapse
E0099010biological_processmodification of postsynaptic structure
E0099243cellular_componentextrinsic component of synaptic membrane
E1905806biological_processregulation of synapse pruning
F0002376biological_processimmune system process
F0003953molecular_functionNAD+ nucleosidase activity
F0005515molecular_functionprotein binding
F0005737cellular_componentcytoplasm
F0005739cellular_componentmitochondrion
F0005741cellular_componentmitochondrial outer membrane
F0005829cellular_componentcytosol
F0005874cellular_componentmicrotubule
F0007165biological_processsignal transduction
F0007399biological_processnervous system development
F0009749biological_processresponse to glucose
F0009986cellular_componentcell surface
F0015630cellular_componentmicrotubule cytoskeleton
F0016787molecular_functionhydrolase activity
F0019677biological_processNAD+ catabolic process
F0030154biological_processcell differentiation
F0030424cellular_componentaxon
F0030425cellular_componentdendrite
F0031594cellular_componentneuromuscular junction
F0032991cellular_componentprotein-containing complex
F0034128biological_processnegative regulation of MyD88-independent toll-like receptor signaling pathway
F0035591molecular_functionsignaling adaptor activity
F0042995cellular_componentcell projection
F0043523biological_processregulation of neuron apoptotic process
F0045087biological_processinnate immune response
F0045202cellular_componentsynapse
F0048678biological_processresponse to axon injury
F0048814biological_processregulation of dendrite morphogenesis
F0050135molecular_functionNADP+ nucleosidase activity
F0050877biological_processnervous system process
F0061809molecular_functionNAD+ nucleosidase activity, cyclic ADP-ribose generating
F0070585biological_processprotein localization to mitochondrion
F0098978cellular_componentglutamatergic synapse
F0099010biological_processmodification of postsynaptic structure
F0099243cellular_componentextrinsic component of synaptic membrane
F1905806biological_processregulation of synapse pruning
G0002376biological_processimmune system process
G0003953molecular_functionNAD+ nucleosidase activity
G0005515molecular_functionprotein binding
G0005737cellular_componentcytoplasm
G0005739cellular_componentmitochondrion
G0005741cellular_componentmitochondrial outer membrane
G0005829cellular_componentcytosol
G0005874cellular_componentmicrotubule
G0007165biological_processsignal transduction
G0007399biological_processnervous system development
G0009749biological_processresponse to glucose
G0009986cellular_componentcell surface
G0015630cellular_componentmicrotubule cytoskeleton
G0016787molecular_functionhydrolase activity
G0019677biological_processNAD+ catabolic process
G0030154biological_processcell differentiation
G0030424cellular_componentaxon
G0030425cellular_componentdendrite
G0031594cellular_componentneuromuscular junction
G0032991cellular_componentprotein-containing complex
G0034128biological_processnegative regulation of MyD88-independent toll-like receptor signaling pathway
G0035591molecular_functionsignaling adaptor activity
G0042995cellular_componentcell projection
G0043523biological_processregulation of neuron apoptotic process
G0045087biological_processinnate immune response
G0045202cellular_componentsynapse
G0048678biological_processresponse to axon injury
G0048814biological_processregulation of dendrite morphogenesis
G0050135molecular_functionNADP+ nucleosidase activity
G0050877biological_processnervous system process
G0061809molecular_functionNAD+ nucleosidase activity, cyclic ADP-ribose generating
G0070585biological_processprotein localization to mitochondrion
G0098978cellular_componentglutamatergic synapse
G0099010biological_processmodification of postsynaptic structure
G0099243cellular_componentextrinsic component of synaptic membrane
G1905806biological_processregulation of synapse pruning
H0002376biological_processimmune system process
H0003953molecular_functionNAD+ nucleosidase activity
H0005515molecular_functionprotein binding
H0005737cellular_componentcytoplasm
H0005739cellular_componentmitochondrion
H0005741cellular_componentmitochondrial outer membrane
H0005829cellular_componentcytosol
H0005874cellular_componentmicrotubule
H0007165biological_processsignal transduction
H0007399biological_processnervous system development
H0009749biological_processresponse to glucose
H0009986cellular_componentcell surface
H0015630cellular_componentmicrotubule cytoskeleton
H0016787molecular_functionhydrolase activity
H0019677biological_processNAD+ catabolic process
H0030154biological_processcell differentiation
H0030424cellular_componentaxon
H0030425cellular_componentdendrite
H0031594cellular_componentneuromuscular junction
H0032991cellular_componentprotein-containing complex
H0034128biological_processnegative regulation of MyD88-independent toll-like receptor signaling pathway
H0035591molecular_functionsignaling adaptor activity
H0042995cellular_componentcell projection
H0043523biological_processregulation of neuron apoptotic process
H0045087biological_processinnate immune response
H0045202cellular_componentsynapse
H0048678biological_processresponse to axon injury
H0048814biological_processregulation of dendrite morphogenesis
H0050135molecular_functionNADP+ nucleosidase activity
H0050877biological_processnervous system process
H0061809molecular_functionNAD+ nucleosidase activity, cyclic ADP-ribose generating
H0070585biological_processprotein localization to mitochondrion
H0098978cellular_componentglutamatergic synapse
H0099010biological_processmodification of postsynaptic structure
H0099243cellular_componentextrinsic component of synaptic membrane
H1905806biological_processregulation of synapse pruning
Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues312
DetailsRepeat: {"description":"ARM 2","evidences":[{"evidenceCode":"ECO:0000255"}]}
ChainResidueDetails

site_idSWS_FT_FI2
Number of Residues304
DetailsRepeat: {"description":"ARM 3","evidences":[{"evidenceCode":"ECO:0000255"}]}
ChainResidueDetails

site_idSWS_FT_FI3
Number of Residues312
DetailsRepeat: {"description":"ARM 4","evidences":[{"evidenceCode":"ECO:0000255"}]}
ChainResidueDetails

site_idSWS_FT_FI4
Number of Residues344
DetailsRepeat: {"description":"ARM 5","evidences":[{"evidenceCode":"ECO:0000255"}]}
ChainResidueDetails

site_idSWS_FT_FI5
Number of Residues344
DetailsRepeat: {"description":"ARM 8","evidences":[{"evidenceCode":"ECO:0000255"}]}
ChainResidueDetails

site_idSWS_FT_FI6
Number of Residues512
DetailsDomain: {"description":"SAM 1","evidences":[{"source":"PROSITE-ProRule","id":"PRU00184","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails

site_idSWS_FT_FI7
Number of Residues8
DetailsActive site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU00204","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"28334607","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"31439792","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"31439793","evidenceCode":"ECO:0000305"}]}
ChainResidueDetails

site_idSWS_FT_FI8
Number of Residues104
DetailsBinding site: {"evidences":[{"source":"PubMed","id":"33053563","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7CM6","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7CM7","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails

site_idSWS_FT_FI9
Number of Residues8
DetailsBinding site: {"evidences":[{"source":"PubMed","id":"31439792","evidenceCode":"ECO:0000305"}]}
ChainResidueDetails

238582

PDB entries from 2025-07-09

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