7LD0

Cryo-EM structure of ligand-free Human SARM1

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0002376	biological_process	immune system process
A	0003953	molecular_function	NAD+ nucleosidase activity
A	0005515	molecular_function	protein binding
A	0005737	cellular_component	cytoplasm
A	0005739	cellular_component	mitochondrion
A	0005741	cellular_component	mitochondrial outer membrane
A	0005829	cellular_component	cytosol
A	0005874	cellular_component	microtubule
A	0007165	biological_process	signal transduction
A	0007399	biological_process	nervous system development
A	0009749	biological_process	response to glucose
A	0009986	cellular_component	cell surface
A	0015630	cellular_component	microtubule cytoskeleton
A	0016787	molecular_function	hydrolase activity
A	0019677	biological_process	NAD+ catabolic process
A	0030154	biological_process	cell differentiation
A	0030424	cellular_component	axon
A	0030425	cellular_component	dendrite
A	0031594	cellular_component	neuromuscular junction
A	0032991	cellular_component	protein-containing complex
A	0034128	biological_process	negative regulation of MyD88-independent toll-like receptor signaling pathway
A	0035591	molecular_function	signaling adaptor activity
A	0042995	cellular_component	cell projection
A	0043523	biological_process	regulation of neuron apoptotic process
A	0045087	biological_process	innate immune response
A	0045202	cellular_component	synapse
A	0048678	biological_process	response to axon injury
A	0048814	biological_process	regulation of dendrite morphogenesis
A	0050135	molecular_function	NADP+ nucleosidase activity
A	0050877	biological_process	nervous system process
A	0061809	molecular_function	NAD+ nucleosidase activity, cyclic ADP-ribose generating
A	0070585	biological_process	protein localization to mitochondrion
A	0098978	cellular_component	glutamatergic synapse
A	0099010	biological_process	modification of postsynaptic structure
A	0099243	cellular_component	extrinsic component of synaptic membrane
A	1905806	biological_process	regulation of synapse pruning
B	0002376	biological_process	immune system process
B	0003953	molecular_function	NAD+ nucleosidase activity
B	0005515	molecular_function	protein binding
B	0005737	cellular_component	cytoplasm
B	0005739	cellular_component	mitochondrion
B	0005741	cellular_component	mitochondrial outer membrane
B	0005829	cellular_component	cytosol
B	0005874	cellular_component	microtubule
B	0007165	biological_process	signal transduction
B	0007399	biological_process	nervous system development
B	0009749	biological_process	response to glucose
B	0009986	cellular_component	cell surface
B	0015630	cellular_component	microtubule cytoskeleton
B	0016787	molecular_function	hydrolase activity
B	0019677	biological_process	NAD+ catabolic process
B	0030154	biological_process	cell differentiation
B	0030424	cellular_component	axon
B	0030425	cellular_component	dendrite
B	0031594	cellular_component	neuromuscular junction
B	0032991	cellular_component	protein-containing complex
B	0034128	biological_process	negative regulation of MyD88-independent toll-like receptor signaling pathway
B	0035591	molecular_function	signaling adaptor activity
B	0042995	cellular_component	cell projection
B	0043523	biological_process	regulation of neuron apoptotic process
B	0045087	biological_process	innate immune response
B	0045202	cellular_component	synapse
B	0048678	biological_process	response to axon injury
B	0048814	biological_process	regulation of dendrite morphogenesis
B	0050135	molecular_function	NADP+ nucleosidase activity
B	0050877	biological_process	nervous system process
B	0061809	molecular_function	NAD+ nucleosidase activity, cyclic ADP-ribose generating
B	0070585	biological_process	protein localization to mitochondrion
B	0098978	cellular_component	glutamatergic synapse
B	0099010	biological_process	modification of postsynaptic structure
B	0099243	cellular_component	extrinsic component of synaptic membrane
B	1905806	biological_process	regulation of synapse pruning
C	0002376	biological_process	immune system process
C	0003953	molecular_function	NAD+ nucleosidase activity
C	0005515	molecular_function	protein binding
C	0005737	cellular_component	cytoplasm
C	0005739	cellular_component	mitochondrion
C	0005741	cellular_component	mitochondrial outer membrane
C	0005829	cellular_component	cytosol
C	0005874	cellular_component	microtubule
C	0007165	biological_process	signal transduction
C	0007399	biological_process	nervous system development
C	0009749	biological_process	response to glucose
C	0009986	cellular_component	cell surface
C	0015630	cellular_component	microtubule cytoskeleton
C	0016787	molecular_function	hydrolase activity
C	0019677	biological_process	NAD+ catabolic process
C	0030154	biological_process	cell differentiation
C	0030424	cellular_component	axon
C	0030425	cellular_component	dendrite
C	0031594	cellular_component	neuromuscular junction
C	0032991	cellular_component	protein-containing complex
C	0034128	biological_process	negative regulation of MyD88-independent toll-like receptor signaling pathway
C	0035591	molecular_function	signaling adaptor activity
C	0042995	cellular_component	cell projection
C	0043523	biological_process	regulation of neuron apoptotic process
C	0045087	biological_process	innate immune response
C	0045202	cellular_component	synapse
C	0048678	biological_process	response to axon injury
C	0048814	biological_process	regulation of dendrite morphogenesis
C	0050135	molecular_function	NADP+ nucleosidase activity
C	0050877	biological_process	nervous system process
C	0061809	molecular_function	NAD+ nucleosidase activity, cyclic ADP-ribose generating
C	0070585	biological_process	protein localization to mitochondrion
C	0098978	cellular_component	glutamatergic synapse
C	0099010	biological_process	modification of postsynaptic structure
C	0099243	cellular_component	extrinsic component of synaptic membrane
C	1905806	biological_process	regulation of synapse pruning
D	0002376	biological_process	immune system process
D	0003953	molecular_function	NAD+ nucleosidase activity
D	0005515	molecular_function	protein binding
D	0005737	cellular_component	cytoplasm
D	0005739	cellular_component	mitochondrion
D	0005741	cellular_component	mitochondrial outer membrane
D	0005829	cellular_component	cytosol
D	0005874	cellular_component	microtubule
D	0007165	biological_process	signal transduction
D	0007399	biological_process	nervous system development
D	0009749	biological_process	response to glucose
D	0009986	cellular_component	cell surface
D	0015630	cellular_component	microtubule cytoskeleton
D	0016787	molecular_function	hydrolase activity
D	0019677	biological_process	NAD+ catabolic process
D	0030154	biological_process	cell differentiation
D	0030424	cellular_component	axon
D	0030425	cellular_component	dendrite
D	0031594	cellular_component	neuromuscular junction
D	0032991	cellular_component	protein-containing complex
D	0034128	biological_process	negative regulation of MyD88-independent toll-like receptor signaling pathway
D	0035591	molecular_function	signaling adaptor activity
D	0042995	cellular_component	cell projection
D	0043523	biological_process	regulation of neuron apoptotic process
D	0045087	biological_process	innate immune response
D	0045202	cellular_component	synapse
D	0048678	biological_process	response to axon injury
D	0048814	biological_process	regulation of dendrite morphogenesis
D	0050135	molecular_function	NADP+ nucleosidase activity
D	0050877	biological_process	nervous system process
D	0061809	molecular_function	NAD+ nucleosidase activity, cyclic ADP-ribose generating
D	0070585	biological_process	protein localization to mitochondrion
D	0098978	cellular_component	glutamatergic synapse
D	0099010	biological_process	modification of postsynaptic structure
D	0099243	cellular_component	extrinsic component of synaptic membrane
D	1905806	biological_process	regulation of synapse pruning
E	0002376	biological_process	immune system process
E	0003953	molecular_function	NAD+ nucleosidase activity
E	0005515	molecular_function	protein binding
E	0005737	cellular_component	cytoplasm
E	0005739	cellular_component	mitochondrion
E	0005741	cellular_component	mitochondrial outer membrane
E	0005829	cellular_component	cytosol
E	0005874	cellular_component	microtubule
E	0007165	biological_process	signal transduction
E	0007399	biological_process	nervous system development
E	0009749	biological_process	response to glucose
E	0009986	cellular_component	cell surface
E	0015630	cellular_component	microtubule cytoskeleton
E	0016787	molecular_function	hydrolase activity
E	0019677	biological_process	NAD+ catabolic process
E	0030154	biological_process	cell differentiation
E	0030424	cellular_component	axon
E	0030425	cellular_component	dendrite
E	0031594	cellular_component	neuromuscular junction
E	0032991	cellular_component	protein-containing complex
E	0034128	biological_process	negative regulation of MyD88-independent toll-like receptor signaling pathway
E	0035591	molecular_function	signaling adaptor activity
E	0042995	cellular_component	cell projection
E	0043523	biological_process	regulation of neuron apoptotic process
E	0045087	biological_process	innate immune response
E	0045202	cellular_component	synapse
E	0048678	biological_process	response to axon injury
E	0048814	biological_process	regulation of dendrite morphogenesis
E	0050135	molecular_function	NADP+ nucleosidase activity
E	0050877	biological_process	nervous system process
E	0061809	molecular_function	NAD+ nucleosidase activity, cyclic ADP-ribose generating
E	0070585	biological_process	protein localization to mitochondrion
E	0098978	cellular_component	glutamatergic synapse
E	0099010	biological_process	modification of postsynaptic structure
E	0099243	cellular_component	extrinsic component of synaptic membrane
E	1905806	biological_process	regulation of synapse pruning
F	0002376	biological_process	immune system process
F	0003953	molecular_function	NAD+ nucleosidase activity
F	0005515	molecular_function	protein binding
F	0005737	cellular_component	cytoplasm
F	0005739	cellular_component	mitochondrion
F	0005741	cellular_component	mitochondrial outer membrane
F	0005829	cellular_component	cytosol
F	0005874	cellular_component	microtubule
F	0007165	biological_process	signal transduction
F	0007399	biological_process	nervous system development
F	0009749	biological_process	response to glucose
F	0009986	cellular_component	cell surface
F	0015630	cellular_component	microtubule cytoskeleton
F	0016787	molecular_function	hydrolase activity
F	0019677	biological_process	NAD+ catabolic process
F	0030154	biological_process	cell differentiation
F	0030424	cellular_component	axon
F	0030425	cellular_component	dendrite
F	0031594	cellular_component	neuromuscular junction
F	0032991	cellular_component	protein-containing complex
F	0034128	biological_process	negative regulation of MyD88-independent toll-like receptor signaling pathway
F	0035591	molecular_function	signaling adaptor activity
F	0042995	cellular_component	cell projection
F	0043523	biological_process	regulation of neuron apoptotic process
F	0045087	biological_process	innate immune response
F	0045202	cellular_component	synapse
F	0048678	biological_process	response to axon injury
F	0048814	biological_process	regulation of dendrite morphogenesis
F	0050135	molecular_function	NADP+ nucleosidase activity
F	0050877	biological_process	nervous system process
F	0061809	molecular_function	NAD+ nucleosidase activity, cyclic ADP-ribose generating
F	0070585	biological_process	protein localization to mitochondrion
F	0098978	cellular_component	glutamatergic synapse
F	0099010	biological_process	modification of postsynaptic structure
F	0099243	cellular_component	extrinsic component of synaptic membrane
F	1905806	biological_process	regulation of synapse pruning
G	0002376	biological_process	immune system process
G	0003953	molecular_function	NAD+ nucleosidase activity
G	0005515	molecular_function	protein binding
G	0005737	cellular_component	cytoplasm
G	0005739	cellular_component	mitochondrion
G	0005741	cellular_component	mitochondrial outer membrane
G	0005829	cellular_component	cytosol
G	0005874	cellular_component	microtubule
G	0007165	biological_process	signal transduction
G	0007399	biological_process	nervous system development
G	0009749	biological_process	response to glucose
G	0009986	cellular_component	cell surface
G	0015630	cellular_component	microtubule cytoskeleton
G	0016787	molecular_function	hydrolase activity
G	0019677	biological_process	NAD+ catabolic process
G	0030154	biological_process	cell differentiation
G	0030424	cellular_component	axon
G	0030425	cellular_component	dendrite
G	0031594	cellular_component	neuromuscular junction
G	0032991	cellular_component	protein-containing complex
G	0034128	biological_process	negative regulation of MyD88-independent toll-like receptor signaling pathway
G	0035591	molecular_function	signaling adaptor activity
G	0042995	cellular_component	cell projection
G	0043523	biological_process	regulation of neuron apoptotic process
G	0045087	biological_process	innate immune response
G	0045202	cellular_component	synapse
G	0048678	biological_process	response to axon injury
G	0048814	biological_process	regulation of dendrite morphogenesis
G	0050135	molecular_function	NADP+ nucleosidase activity
G	0050877	biological_process	nervous system process
G	0061809	molecular_function	NAD+ nucleosidase activity, cyclic ADP-ribose generating
G	0070585	biological_process	protein localization to mitochondrion
G	0098978	cellular_component	glutamatergic synapse
G	0099010	biological_process	modification of postsynaptic structure
G	0099243	cellular_component	extrinsic component of synaptic membrane
G	1905806	biological_process	regulation of synapse pruning
H	0002376	biological_process	immune system process
H	0003953	molecular_function	NAD+ nucleosidase activity
H	0005515	molecular_function	protein binding
H	0005737	cellular_component	cytoplasm
H	0005739	cellular_component	mitochondrion
H	0005741	cellular_component	mitochondrial outer membrane
H	0005829	cellular_component	cytosol
H	0005874	cellular_component	microtubule
H	0007165	biological_process	signal transduction
H	0007399	biological_process	nervous system development
H	0009749	biological_process	response to glucose
H	0009986	cellular_component	cell surface
H	0015630	cellular_component	microtubule cytoskeleton
H	0016787	molecular_function	hydrolase activity
H	0019677	biological_process	NAD+ catabolic process
H	0030154	biological_process	cell differentiation
H	0030424	cellular_component	axon
H	0030425	cellular_component	dendrite
H	0031594	cellular_component	neuromuscular junction
H	0032991	cellular_component	protein-containing complex
H	0034128	biological_process	negative regulation of MyD88-independent toll-like receptor signaling pathway
H	0035591	molecular_function	signaling adaptor activity
H	0042995	cellular_component	cell projection
H	0043523	biological_process	regulation of neuron apoptotic process
H	0045087	biological_process	innate immune response
H	0045202	cellular_component	synapse
H	0048678	biological_process	response to axon injury
H	0048814	biological_process	regulation of dendrite morphogenesis
H	0050135	molecular_function	NADP+ nucleosidase activity
H	0050877	biological_process	nervous system process
H	0061809	molecular_function	NAD+ nucleosidase activity, cyclic ADP-ribose generating
H	0070585	biological_process	protein localization to mitochondrion
H	0098978	cellular_component	glutamatergic synapse
H	0099010	biological_process	modification of postsynaptic structure
H	0099243	cellular_component	extrinsic component of synaptic membrane
H	1905806	biological_process	regulation of synapse pruning

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	312
Details	Repeat: {"description":"ARM 2","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	304
Details	Repeat: {"description":"ARM 3","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	312
Details	Repeat: {"description":"ARM 4","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	344
Details	Repeat: {"description":"ARM 5","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	344
Details	Repeat: {"description":"ARM 8","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	512
Details	Domain: {"description":"SAM 1","evidences":[{"source":"PROSITE-ProRule","id":"PRU00184","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI7
Number of Residues	8
Details	Active site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU00204","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"28334607","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"31439792","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"31439793","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI8
Number of Residues	104
Details	Binding site: {"evidences":[{"source":"PubMed","id":"33053563","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7CM6","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7CM7","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI9
Number of Residues	8
Details	Binding site: {"evidences":[{"source":"PubMed","id":"31439792","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

---