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7LD0

Cryo-EM structure of ligand-free Human SARM1

Functional Information from GO Data
ChainGOidnamespacecontents
A0003953molecular_functionNAD+ nucleosidase activity
A0005515molecular_functionprotein binding
A0005737cellular_componentcytoplasm
A0005739cellular_componentmitochondrion
A0005741cellular_componentmitochondrial outer membrane
A0005829cellular_componentcytosol
A0005874cellular_componentmicrotubule
A0007165biological_processsignal transduction
A0007399biological_processnervous system development
A0009749biological_processresponse to glucose
A0009986cellular_componentcell surface
A0015630cellular_componentmicrotubule cytoskeleton
A0016787molecular_functionhydrolase activity
A0019677biological_processNAD catabolic process
A0030154biological_processcell differentiation
A0030424cellular_componentaxon
A0030425cellular_componentdendrite
A0031594cellular_componentneuromuscular junction
A0032991cellular_componentprotein-containing complex
A0034128biological_processnegative regulation of MyD88-independent toll-like receptor signaling pathway
A0035591molecular_functionsignaling adaptor activity
A0042995cellular_componentcell projection
A0043523biological_processregulation of neuron apoptotic process
A0045087biological_processinnate immune response
A0045202cellular_componentsynapse
A0048678biological_processresponse to axon injury
A0048814biological_processregulation of dendrite morphogenesis
A0050135molecular_functionNADP+ nucleosidase activity
A0050877biological_processnervous system process
A0061809molecular_functionNAD+ nucleotidase, cyclic ADP-ribose generating
A0070585biological_processprotein localization to mitochondrion
A0098978cellular_componentglutamatergic synapse
A0099010biological_processmodification of postsynaptic structure
A0099243cellular_componentextrinsic component of synaptic membrane
A1905806biological_processregulation of synapse pruning
B0003953molecular_functionNAD+ nucleosidase activity
B0005515molecular_functionprotein binding
B0005737cellular_componentcytoplasm
B0005739cellular_componentmitochondrion
B0005741cellular_componentmitochondrial outer membrane
B0005829cellular_componentcytosol
B0005874cellular_componentmicrotubule
B0007165biological_processsignal transduction
B0007399biological_processnervous system development
B0009749biological_processresponse to glucose
B0009986cellular_componentcell surface
B0015630cellular_componentmicrotubule cytoskeleton
B0016787molecular_functionhydrolase activity
B0019677biological_processNAD catabolic process
B0030154biological_processcell differentiation
B0030424cellular_componentaxon
B0030425cellular_componentdendrite
B0031594cellular_componentneuromuscular junction
B0032991cellular_componentprotein-containing complex
B0034128biological_processnegative regulation of MyD88-independent toll-like receptor signaling pathway
B0035591molecular_functionsignaling adaptor activity
B0042995cellular_componentcell projection
B0043523biological_processregulation of neuron apoptotic process
B0045087biological_processinnate immune response
B0045202cellular_componentsynapse
B0048678biological_processresponse to axon injury
B0048814biological_processregulation of dendrite morphogenesis
B0050135molecular_functionNADP+ nucleosidase activity
B0050877biological_processnervous system process
B0061809molecular_functionNAD+ nucleotidase, cyclic ADP-ribose generating
B0070585biological_processprotein localization to mitochondrion
B0098978cellular_componentglutamatergic synapse
B0099010biological_processmodification of postsynaptic structure
B0099243cellular_componentextrinsic component of synaptic membrane
B1905806biological_processregulation of synapse pruning
C0003953molecular_functionNAD+ nucleosidase activity
C0005515molecular_functionprotein binding
C0005737cellular_componentcytoplasm
C0005739cellular_componentmitochondrion
C0005741cellular_componentmitochondrial outer membrane
C0005829cellular_componentcytosol
C0005874cellular_componentmicrotubule
C0007165biological_processsignal transduction
C0007399biological_processnervous system development
C0009749biological_processresponse to glucose
C0009986cellular_componentcell surface
C0015630cellular_componentmicrotubule cytoskeleton
C0016787molecular_functionhydrolase activity
C0019677biological_processNAD catabolic process
C0030154biological_processcell differentiation
C0030424cellular_componentaxon
C0030425cellular_componentdendrite
C0031594cellular_componentneuromuscular junction
C0032991cellular_componentprotein-containing complex
C0034128biological_processnegative regulation of MyD88-independent toll-like receptor signaling pathway
C0035591molecular_functionsignaling adaptor activity
C0042995cellular_componentcell projection
C0043523biological_processregulation of neuron apoptotic process
C0045087biological_processinnate immune response
C0045202cellular_componentsynapse
C0048678biological_processresponse to axon injury
C0048814biological_processregulation of dendrite morphogenesis
C0050135molecular_functionNADP+ nucleosidase activity
C0050877biological_processnervous system process
C0061809molecular_functionNAD+ nucleotidase, cyclic ADP-ribose generating
C0070585biological_processprotein localization to mitochondrion
C0098978cellular_componentglutamatergic synapse
C0099010biological_processmodification of postsynaptic structure
C0099243cellular_componentextrinsic component of synaptic membrane
C1905806biological_processregulation of synapse pruning
D0003953molecular_functionNAD+ nucleosidase activity
D0005515molecular_functionprotein binding
D0005737cellular_componentcytoplasm
D0005739cellular_componentmitochondrion
D0005741cellular_componentmitochondrial outer membrane
D0005829cellular_componentcytosol
D0005874cellular_componentmicrotubule
D0007165biological_processsignal transduction
D0007399biological_processnervous system development
D0009749biological_processresponse to glucose
D0009986cellular_componentcell surface
D0015630cellular_componentmicrotubule cytoskeleton
D0016787molecular_functionhydrolase activity
D0019677biological_processNAD catabolic process
D0030154biological_processcell differentiation
D0030424cellular_componentaxon
D0030425cellular_componentdendrite
D0031594cellular_componentneuromuscular junction
D0032991cellular_componentprotein-containing complex
D0034128biological_processnegative regulation of MyD88-independent toll-like receptor signaling pathway
D0035591molecular_functionsignaling adaptor activity
D0042995cellular_componentcell projection
D0043523biological_processregulation of neuron apoptotic process
D0045087biological_processinnate immune response
D0045202cellular_componentsynapse
D0048678biological_processresponse to axon injury
D0048814biological_processregulation of dendrite morphogenesis
D0050135molecular_functionNADP+ nucleosidase activity
D0050877biological_processnervous system process
D0061809molecular_functionNAD+ nucleotidase, cyclic ADP-ribose generating
D0070585biological_processprotein localization to mitochondrion
D0098978cellular_componentglutamatergic synapse
D0099010biological_processmodification of postsynaptic structure
D0099243cellular_componentextrinsic component of synaptic membrane
D1905806biological_processregulation of synapse pruning
E0003953molecular_functionNAD+ nucleosidase activity
E0005515molecular_functionprotein binding
E0005737cellular_componentcytoplasm
E0005739cellular_componentmitochondrion
E0005741cellular_componentmitochondrial outer membrane
E0005829cellular_componentcytosol
E0005874cellular_componentmicrotubule
E0007165biological_processsignal transduction
E0007399biological_processnervous system development
E0009749biological_processresponse to glucose
E0009986cellular_componentcell surface
E0015630cellular_componentmicrotubule cytoskeleton
E0016787molecular_functionhydrolase activity
E0019677biological_processNAD catabolic process
E0030154biological_processcell differentiation
E0030424cellular_componentaxon
E0030425cellular_componentdendrite
E0031594cellular_componentneuromuscular junction
E0032991cellular_componentprotein-containing complex
E0034128biological_processnegative regulation of MyD88-independent toll-like receptor signaling pathway
E0035591molecular_functionsignaling adaptor activity
E0042995cellular_componentcell projection
E0043523biological_processregulation of neuron apoptotic process
E0045087biological_processinnate immune response
E0045202cellular_componentsynapse
E0048678biological_processresponse to axon injury
E0048814biological_processregulation of dendrite morphogenesis
E0050135molecular_functionNADP+ nucleosidase activity
E0050877biological_processnervous system process
E0061809molecular_functionNAD+ nucleotidase, cyclic ADP-ribose generating
E0070585biological_processprotein localization to mitochondrion
E0098978cellular_componentglutamatergic synapse
E0099010biological_processmodification of postsynaptic structure
E0099243cellular_componentextrinsic component of synaptic membrane
E1905806biological_processregulation of synapse pruning
F0003953molecular_functionNAD+ nucleosidase activity
F0005515molecular_functionprotein binding
F0005737cellular_componentcytoplasm
F0005739cellular_componentmitochondrion
F0005741cellular_componentmitochondrial outer membrane
F0005829cellular_componentcytosol
F0005874cellular_componentmicrotubule
F0007165biological_processsignal transduction
F0007399biological_processnervous system development
F0009749biological_processresponse to glucose
F0009986cellular_componentcell surface
F0015630cellular_componentmicrotubule cytoskeleton
F0016787molecular_functionhydrolase activity
F0019677biological_processNAD catabolic process
F0030154biological_processcell differentiation
F0030424cellular_componentaxon
F0030425cellular_componentdendrite
F0031594cellular_componentneuromuscular junction
F0032991cellular_componentprotein-containing complex
F0034128biological_processnegative regulation of MyD88-independent toll-like receptor signaling pathway
F0035591molecular_functionsignaling adaptor activity
F0042995cellular_componentcell projection
F0043523biological_processregulation of neuron apoptotic process
F0045087biological_processinnate immune response
F0045202cellular_componentsynapse
F0048678biological_processresponse to axon injury
F0048814biological_processregulation of dendrite morphogenesis
F0050135molecular_functionNADP+ nucleosidase activity
F0050877biological_processnervous system process
F0061809molecular_functionNAD+ nucleotidase, cyclic ADP-ribose generating
F0070585biological_processprotein localization to mitochondrion
F0098978cellular_componentglutamatergic synapse
F0099010biological_processmodification of postsynaptic structure
F0099243cellular_componentextrinsic component of synaptic membrane
F1905806biological_processregulation of synapse pruning
G0003953molecular_functionNAD+ nucleosidase activity
G0005515molecular_functionprotein binding
G0005737cellular_componentcytoplasm
G0005739cellular_componentmitochondrion
G0005741cellular_componentmitochondrial outer membrane
G0005829cellular_componentcytosol
G0005874cellular_componentmicrotubule
G0007165biological_processsignal transduction
G0007399biological_processnervous system development
G0009749biological_processresponse to glucose
G0009986cellular_componentcell surface
G0015630cellular_componentmicrotubule cytoskeleton
G0016787molecular_functionhydrolase activity
G0019677biological_processNAD catabolic process
G0030154biological_processcell differentiation
G0030424cellular_componentaxon
G0030425cellular_componentdendrite
G0031594cellular_componentneuromuscular junction
G0032991cellular_componentprotein-containing complex
G0034128biological_processnegative regulation of MyD88-independent toll-like receptor signaling pathway
G0035591molecular_functionsignaling adaptor activity
G0042995cellular_componentcell projection
G0043523biological_processregulation of neuron apoptotic process
G0045087biological_processinnate immune response
G0045202cellular_componentsynapse
G0048678biological_processresponse to axon injury
G0048814biological_processregulation of dendrite morphogenesis
G0050135molecular_functionNADP+ nucleosidase activity
G0050877biological_processnervous system process
G0061809molecular_functionNAD+ nucleotidase, cyclic ADP-ribose generating
G0070585biological_processprotein localization to mitochondrion
G0098978cellular_componentglutamatergic synapse
G0099010biological_processmodification of postsynaptic structure
G0099243cellular_componentextrinsic component of synaptic membrane
G1905806biological_processregulation of synapse pruning
H0003953molecular_functionNAD+ nucleosidase activity
H0005515molecular_functionprotein binding
H0005737cellular_componentcytoplasm
H0005739cellular_componentmitochondrion
H0005741cellular_componentmitochondrial outer membrane
H0005829cellular_componentcytosol
H0005874cellular_componentmicrotubule
H0007165biological_processsignal transduction
H0007399biological_processnervous system development
H0009749biological_processresponse to glucose
H0009986cellular_componentcell surface
H0015630cellular_componentmicrotubule cytoskeleton
H0016787molecular_functionhydrolase activity
H0019677biological_processNAD catabolic process
H0030154biological_processcell differentiation
H0030424cellular_componentaxon
H0030425cellular_componentdendrite
H0031594cellular_componentneuromuscular junction
H0032991cellular_componentprotein-containing complex
H0034128biological_processnegative regulation of MyD88-independent toll-like receptor signaling pathway
H0035591molecular_functionsignaling adaptor activity
H0042995cellular_componentcell projection
H0043523biological_processregulation of neuron apoptotic process
H0045087biological_processinnate immune response
H0045202cellular_componentsynapse
H0048678biological_processresponse to axon injury
H0048814biological_processregulation of dendrite morphogenesis
H0050135molecular_functionNADP+ nucleosidase activity
H0050877biological_processnervous system process
H0061809molecular_functionNAD+ nucleotidase, cyclic ADP-ribose generating
H0070585biological_processprotein localization to mitochondrion
H0098978cellular_componentglutamatergic synapse
H0099010biological_processmodification of postsynaptic structure
H0099243cellular_componentextrinsic component of synaptic membrane
H1905806biological_processregulation of synapse pruning
Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues8
DetailsACT_SITE: ACT_SITE => ECO:0000255|PROSITE-ProRule:PRU00204, ECO:0000305|PubMed:28334607, ECO:0000305|PubMed:31439792, ECO:0000305|PubMed:31439793
ChainResidueDetails
AGLU642
BGLU642
CGLU642
DGLU642
EGLU642
FGLU642
GGLU642
HGLU642

site_idSWS_FT_FI2
Number of Residues32
DetailsBINDING: BINDING => ECO:0000269|PubMed:33053563, ECO:0007744|PDB:7CM6, ECO:0007744|PDB:7CM7
ChainResidueDetails
ATRP103
CARG110
CGLU149
CHIS190
DTRP103
DARG110
DGLU149
DHIS190
ETRP103
EARG110
EGLU149
AARG110
EHIS190
FTRP103
FARG110
FGLU149
FHIS190
GTRP103
GARG110
GGLU149
GHIS190
HTRP103
AGLU149
HARG110
HGLU149
HHIS190
AHIS190
BTRP103
BARG110
BGLU149
BHIS190
CTRP103

site_idSWS_FT_FI3
Number of Residues16
DetailsBINDING: BINDING => ECO:0000305|PubMed:31439792
ChainResidueDetails
AARG569
EGLU599
FARG569
FGLU599
GARG569
GGLU599
HARG569
HGLU599
AGLU599
BARG569
BGLU599
CARG569
CGLU599
DARG569
DGLU599
EARG569

site_idSWS_FT_FI4
Number of Residues8
DetailsMOD_RES: Phosphoserine => ECO:0000269|PubMed:30333228
ChainResidueDetails
ASER548
BSER548
CSER548
DSER548
ESER548
FSER548
GSER548
HSER548

site_idSWS_FT_FI5
Number of Residues8
DetailsMOD_RES: Phosphoserine => ECO:0000250|UniProtKB:Q6PDS3
ChainResidueDetails
ASER558
BSER558
CSER558
DSER558
ESER558
FSER558
GSER558
HSER558

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PDB entries from 2024-11-06

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