8P2L

A CHIMERA construct containing human SARM1 ARM and SAM domains and C. elegans TIR domain.

Summary for 8P2L

• Entry DOI: 10.2210/pdb8p2l/pdb
• EMDB information: 17369
• Descriptor: NAD(+) hydrolase SARM1,NAD(+) hydrolase tir-1, NICOTINAMIDE-ADENINE-DINUCLEOTIDE (2 entities in total)
• Functional Keywords: sarm1; tir-1; c. elegans; neurodegeneration; cryo-em; structural biology; nad+ metabolism; axon wallerian degeneration, hydrolase
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 16
• Total formula weight: 1302437.90

Authors

Isupov, M.N.,Opatowsky, Y. (deposition date: 2023-05-16, release date: 2023-09-06)

• Primary citation: Khazma, T.,Grossman, A.,Guez-Haddad, J.,Feng, C.,Dabas, H.,Sain, R.,Weitman, M.,Zalk, R.,Isupov, M.N.,Hammarlund, M.,Hons, M.,Opatowsky, Y.; Structure-function analysis of ceTIR-1/hSARM1 explains the lack of Wallerian axonal degeneration in C. elegans.; Cell Rep, 42:113026-113026, 2023; PubMed: 37635352; DOI: 10.1016/j.celrep.2023.113026

Experimental method

ELECTRON MICROSCOPY (2.68 Å)