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SummaryStructural detailsExperimental detailsFunctional detailsSequence NeighborHistoryDownloads

8P2L

A CHIMERA construct containing human SARM1 ARM and SAM domains and C. elegans TIR domain.

Functional Information from GO Data
ChainGOidnamespacecontents
A0003953molecular_functionNAD+ nucleosidase activity
A0007165biological_processsignal transduction
A0034128biological_processnegative regulation of MyD88-independent toll-like receptor signaling pathway
A0035591molecular_functionsignaling adaptor activity
A0048678biological_processresponse to axon injury
B0003953molecular_functionNAD+ nucleosidase activity
B0007165biological_processsignal transduction
B0034128biological_processnegative regulation of MyD88-independent toll-like receptor signaling pathway
B0035591molecular_functionsignaling adaptor activity
B0048678biological_processresponse to axon injury
C0003953molecular_functionNAD+ nucleosidase activity
C0007165biological_processsignal transduction
C0034128biological_processnegative regulation of MyD88-independent toll-like receptor signaling pathway
C0035591molecular_functionsignaling adaptor activity
C0048678biological_processresponse to axon injury
D0003953molecular_functionNAD+ nucleosidase activity
D0007165biological_processsignal transduction
D0034128biological_processnegative regulation of MyD88-independent toll-like receptor signaling pathway
D0035591molecular_functionsignaling adaptor activity
D0048678biological_processresponse to axon injury
E0003953molecular_functionNAD+ nucleosidase activity
E0007165biological_processsignal transduction
E0034128biological_processnegative regulation of MyD88-independent toll-like receptor signaling pathway
E0035591molecular_functionsignaling adaptor activity
E0048678biological_processresponse to axon injury
F0003953molecular_functionNAD+ nucleosidase activity
F0007165biological_processsignal transduction
F0034128biological_processnegative regulation of MyD88-independent toll-like receptor signaling pathway
F0035591molecular_functionsignaling adaptor activity
F0048678biological_processresponse to axon injury
G0003953molecular_functionNAD+ nucleosidase activity
G0007165biological_processsignal transduction
G0034128biological_processnegative regulation of MyD88-independent toll-like receptor signaling pathway
G0035591molecular_functionsignaling adaptor activity
G0048678biological_processresponse to axon injury
H0003953molecular_functionNAD+ nucleosidase activity
H0007165biological_processsignal transduction
H0034128biological_processnegative regulation of MyD88-independent toll-like receptor signaling pathway
H0035591molecular_functionsignaling adaptor activity
H0048678biological_processresponse to axon injury
I0003953molecular_functionNAD+ nucleosidase activity
I0007165biological_processsignal transduction
I0034128biological_processnegative regulation of MyD88-independent toll-like receptor signaling pathway
I0035591molecular_functionsignaling adaptor activity
I0048678biological_processresponse to axon injury
J0003953molecular_functionNAD+ nucleosidase activity
J0007165biological_processsignal transduction
J0034128biological_processnegative regulation of MyD88-independent toll-like receptor signaling pathway
J0035591molecular_functionsignaling adaptor activity
J0048678biological_processresponse to axon injury
K0003953molecular_functionNAD+ nucleosidase activity
K0007165biological_processsignal transduction
K0034128biological_processnegative regulation of MyD88-independent toll-like receptor signaling pathway
K0035591molecular_functionsignaling adaptor activity
K0048678biological_processresponse to axon injury
L0003953molecular_functionNAD+ nucleosidase activity
L0007165biological_processsignal transduction
L0034128biological_processnegative regulation of MyD88-independent toll-like receptor signaling pathway
L0035591molecular_functionsignaling adaptor activity
L0048678biological_processresponse to axon injury
M0003953molecular_functionNAD+ nucleosidase activity
M0007165biological_processsignal transduction
M0034128biological_processnegative regulation of MyD88-independent toll-like receptor signaling pathway
M0035591molecular_functionsignaling adaptor activity
M0048678biological_processresponse to axon injury
N0003953molecular_functionNAD+ nucleosidase activity
N0007165biological_processsignal transduction
N0034128biological_processnegative regulation of MyD88-independent toll-like receptor signaling pathway
N0035591molecular_functionsignaling adaptor activity
N0048678biological_processresponse to axon injury
O0003953molecular_functionNAD+ nucleosidase activity
O0007165biological_processsignal transduction
O0034128biological_processnegative regulation of MyD88-independent toll-like receptor signaling pathway
O0035591molecular_functionsignaling adaptor activity
O0048678biological_processresponse to axon injury
P0003953molecular_functionNAD+ nucleosidase activity
P0007165biological_processsignal transduction
P0034128biological_processnegative regulation of MyD88-independent toll-like receptor signaling pathway
P0035591molecular_functionsignaling adaptor activity
P0048678biological_processresponse to axon injury
Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues320
DetailsRepeat: {"description":"ARM 1","evidences":[{"evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI2
Number of Residues312
DetailsRepeat: {"description":"ARM 2","evidences":[{"evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI3
Number of Residues304
DetailsRepeat: {"description":"ARM 3","evidences":[{"evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI4
Number of Residues312
DetailsRepeat: {"description":"ARM 4","evidences":[{"evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI5
Number of Residues344
DetailsRepeat: {"description":"ARM 5","evidences":[{"evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI6
Number of Residues264
DetailsRepeat: {"description":"ARM 6","evidences":[{"evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI7
Number of Residues312
DetailsRepeat: {"description":"ARM 7","evidences":[{"evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI8
Number of Residues344
DetailsRepeat: {"description":"ARM 8","evidences":[{"evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI9
Number of Residues512
DetailsDomain: {"description":"SAM 1","evidences":[{"source":"PROSITE-ProRule","id":"PRU00184","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI10
Number of Residues496
DetailsDomain: {"description":"SAM 2","evidences":[{"source":"PROSITE-ProRule","id":"PRU00184","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI11
Number of Residues104
DetailsBinding site: {"evidences":[{"source":"PubMed","id":"33053563","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7CM6","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7CM7","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI12
Number of Residues8
DetailsModified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"30333228","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI13
Number of Residues8
DetailsActive site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU00204","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI14
Number of Residues8
DetailsBinding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU00204","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI15
Number of Residues8
DetailsBinding site: {"evidences":[{"source":"PubMed","id":"31439792","evidenceCode":"ECO:0000305"}]}
ChainResidueDetails

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PDB entries from 2026-02-11

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