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8P2L

A CHIMERA construct containing human SARM1 ARM and SAM domains and C. elegans TIR domain.

Functional Information from GO Data
ChainGOidnamespacecontents
A0003953molecular_functionNAD+ nucleosidase activity
A0007165biological_processsignal transduction
A0034128biological_processnegative regulation of MyD88-independent toll-like receptor signaling pathway
A0035591molecular_functionsignaling adaptor activity
A0048678biological_processresponse to axon injury
B0003953molecular_functionNAD+ nucleosidase activity
B0007165biological_processsignal transduction
B0034128biological_processnegative regulation of MyD88-independent toll-like receptor signaling pathway
B0035591molecular_functionsignaling adaptor activity
B0048678biological_processresponse to axon injury
C0003953molecular_functionNAD+ nucleosidase activity
C0007165biological_processsignal transduction
C0034128biological_processnegative regulation of MyD88-independent toll-like receptor signaling pathway
C0035591molecular_functionsignaling adaptor activity
C0048678biological_processresponse to axon injury
D0003953molecular_functionNAD+ nucleosidase activity
D0007165biological_processsignal transduction
D0034128biological_processnegative regulation of MyD88-independent toll-like receptor signaling pathway
D0035591molecular_functionsignaling adaptor activity
D0048678biological_processresponse to axon injury
E0003953molecular_functionNAD+ nucleosidase activity
E0007165biological_processsignal transduction
E0034128biological_processnegative regulation of MyD88-independent toll-like receptor signaling pathway
E0035591molecular_functionsignaling adaptor activity
E0048678biological_processresponse to axon injury
F0003953molecular_functionNAD+ nucleosidase activity
F0007165biological_processsignal transduction
F0034128biological_processnegative regulation of MyD88-independent toll-like receptor signaling pathway
F0035591molecular_functionsignaling adaptor activity
F0048678biological_processresponse to axon injury
G0003953molecular_functionNAD+ nucleosidase activity
G0007165biological_processsignal transduction
G0034128biological_processnegative regulation of MyD88-independent toll-like receptor signaling pathway
G0035591molecular_functionsignaling adaptor activity
G0048678biological_processresponse to axon injury
H0003953molecular_functionNAD+ nucleosidase activity
H0007165biological_processsignal transduction
H0034128biological_processnegative regulation of MyD88-independent toll-like receptor signaling pathway
H0035591molecular_functionsignaling adaptor activity
H0048678biological_processresponse to axon injury
I0003953molecular_functionNAD+ nucleosidase activity
I0007165biological_processsignal transduction
I0034128biological_processnegative regulation of MyD88-independent toll-like receptor signaling pathway
I0035591molecular_functionsignaling adaptor activity
I0048678biological_processresponse to axon injury
J0003953molecular_functionNAD+ nucleosidase activity
J0007165biological_processsignal transduction
J0034128biological_processnegative regulation of MyD88-independent toll-like receptor signaling pathway
J0035591molecular_functionsignaling adaptor activity
J0048678biological_processresponse to axon injury
K0003953molecular_functionNAD+ nucleosidase activity
K0007165biological_processsignal transduction
K0034128biological_processnegative regulation of MyD88-independent toll-like receptor signaling pathway
K0035591molecular_functionsignaling adaptor activity
K0048678biological_processresponse to axon injury
L0003953molecular_functionNAD+ nucleosidase activity
L0007165biological_processsignal transduction
L0034128biological_processnegative regulation of MyD88-independent toll-like receptor signaling pathway
L0035591molecular_functionsignaling adaptor activity
L0048678biological_processresponse to axon injury
M0003953molecular_functionNAD+ nucleosidase activity
M0007165biological_processsignal transduction
M0034128biological_processnegative regulation of MyD88-independent toll-like receptor signaling pathway
M0035591molecular_functionsignaling adaptor activity
M0048678biological_processresponse to axon injury
N0003953molecular_functionNAD+ nucleosidase activity
N0007165biological_processsignal transduction
N0034128biological_processnegative regulation of MyD88-independent toll-like receptor signaling pathway
N0035591molecular_functionsignaling adaptor activity
N0048678biological_processresponse to axon injury
O0003953molecular_functionNAD+ nucleosidase activity
O0007165biological_processsignal transduction
O0034128biological_processnegative regulation of MyD88-independent toll-like receptor signaling pathway
O0035591molecular_functionsignaling adaptor activity
O0048678biological_processresponse to axon injury
P0003953molecular_functionNAD+ nucleosidase activity
P0007165biological_processsignal transduction
P0034128biological_processnegative regulation of MyD88-independent toll-like receptor signaling pathway
P0035591molecular_functionsignaling adaptor activity
P0048678biological_processresponse to axon injury
Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues64
DetailsBINDING: BINDING => ECO:0000269|PubMed:33053563, ECO:0007744|PDB:7CM6, ECO:0007744|PDB:7CM7
ChainResidueDetails
ATRP103
CARG110
CGLU149
CHIS190
DTRP103
DARG110
DGLU149
DHIS190
ETRP103
EARG110
EGLU149
AARG110
EHIS190
FTRP103
FARG110
FGLU149
FHIS190
GTRP103
GARG110
GGLU149
GHIS190
HTRP103
AGLU149
HARG110
HGLU149
HHIS190
JTRP249
JARG256
JGLU295
JHIS336
ITRP249
IARG256
IGLU295
AHIS190
IHIS336
KTRP249
KARG256
KGLU295
KHIS336
LTRP249
LARG256
LGLU295
LHIS336
MTRP249
BTRP103
MARG256
MGLU295
MHIS336
NTRP249
NARG256
NGLU295
NHIS336
OTRP249
OARG256
OGLU295
BARG110
OHIS336
PTRP249
PARG256
PGLU295
PHIS336
BGLU149
BHIS190
CTRP103

site_idSWS_FT_FI2
Number of Residues16
DetailsBINDING: BINDING => ECO:0000305|PubMed:31439792
ChainResidueDetails
AARG569
IARG715
KARG715
LARG715
MARG715
NARG715
OARG715
PARG715
BARG569
CARG569
DARG569
EARG569
FARG569
GARG569
HARG569
JARG715

site_idSWS_FT_FI3
Number of Residues16
DetailsMOD_RES: Phosphoserine => ECO:0000269|PubMed:30333228
ChainResidueDetails
ASER548
ISER694
KSER694
LSER694
MSER694
NSER694
OSER694
PSER694
BSER548
CSER548
DSER548
ESER548
FSER548
GSER548
HSER548
JSER694

site_idSWS_FT_FI4
Number of Residues16
DetailsMOD_RES: Phosphoserine => ECO:0000250|UniProtKB:Q6PDS3
ChainResidueDetails
ASER558
ISER704
KSER704
LSER704
MSER704
NSER704
OSER704
PSER704
BSER558
CSER558
DSER558
ESER558
FSER558
GSER558
HSER558
JSER704

site_idSWS_FT_FI5
Number of Residues16
DetailsACT_SITE: ACT_SITE => ECO:0000255|PROSITE-ProRule:PRU00204
ChainResidueDetails
AGLU642
IGLU788
KGLU788
LGLU788
MGLU788
NGLU788
OGLU788
PGLU788
BGLU642
CGLU642
DGLU642
EGLU642
FGLU642
GGLU642
HGLU642
JGLU788

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PDB entries from 2024-05-08

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