8P2L

A CHIMERA construct containing human SARM1 ARM and SAM domains and C. elegans TIR domain.

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B, C, D, E... (A, B, C, D, E...)	NAD(+) hydrolase SARM1,NAD(+) hydrolase tir-1	polymer	728	81070.7	16	UniProt (Q6SZW1) UniProt (Q86DA5) Pfam (PF07647) Pfam (PF13676)	Homo sapiens (human)	NADase SARM1,hSARM1,NADP(+) hydrolase SARM1,Sterile alpha and Armadillo repeat protein,Sterile alpha and TIR motif-containing protein 1,Sterile alpha motif domain-containing protein 2,MyD88-5,SAM domain-containing protein 2,Tir-1 homolog,HsTIR,NADase tir-1,Neuronal symmetry protein 2,SARM1 homolog,Sterile alpha and TIR motif-containing protein tir-1
2	Q, R, S, T, U... (A, B, C, D, E...)	NICOTINAMIDE-ADENINE-DINUCLEOTIDE	non-polymer		663.4	8	Chemie (NAD)

Sequence modifications

A, B, C, D, E, F, G, H, J, I, K, L, M, N, O, P: 26 - 562 (UniProt: Q6SZW1)

PDB	External Database	Details
Met -1	-	initiating methionine
Ser 0	-	expression tag
Tyr 1	-	expression tag
His 2	-	expression tag
His 3	-	expression tag
His 4	-	expression tag
His 5	-	expression tag
His 6	-	expression tag
His 7	-	expression tag
Asp 8	-	expression tag
Tyr 9	-	expression tag
Asp 10	-	expression tag
Ile 11	-	expression tag
Pro 12	-	expression tag
Thr 13	-	expression tag
Thr 14	-	expression tag
Glu 15	-	expression tag
Asn 16	-	expression tag
Leu 17	-	expression tag
Tyr 18	-	expression tag
Phe 19	-	expression tag
Gln 20	-	expression tag
Gly 21	-	expression tag
Ala 22	-	expression tag
Met 23	-	expression tag
Gly 24	-	expression tag
Ser 25	-	expression tag

A, B, C, D, E, F, G, H, J, I, K, L, M, N, O, P: 563 - 726 (UniProt: Q86DA5)

Contents of the asymmetric unit

Polymers	Number of chains	16
	Total formula weight	1297130.5
Non-Polymers*	Number of molecules	8
	Total formula weight	5307.4
All*	Total formula weight	1302437.9

*Water molecules are not included.