8GQ5

Human SARM1 bounded with NMN and Nanobody-C6, double-layer structure

Summary for 8GQ5

• Entry DOI: 10.2210/pdb8gq5/pdb
• EMDB information: 34198
• Descriptor: NAD(+) hydrolase SARM1, Nanobody C6 (2 entities in total)
• Functional Keywords: nad(+)hydrolase, nmn, nanobody, hydrolase
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 32
• Total formula weight: 1482478.69

Authors

Cai, Y.,Zhang, H. (deposition date: 2022-08-29, release date: 2023-01-18)

• Primary citation: Hou, Y.N.,Cai, Y.,Li, W.H.,He, W.M.,Zhao, Z.Y.,Zhu, W.J.,Wang, Q.,Mai, X.,Liu, J.,Lee, H.C.,Stjepanovic, G.,Zhang, H.,Zhao, Y.J.; A conformation-specific nanobody targeting the nicotinamide mononucleotide-activated state of SARM1.; Nat Commun, 13:7898-7898, 2022; PubMed: 36550129; DOI: 10.1038/s41467-022-35581-y

Experimental method

ELECTRON MICROSCOPY (2.7 Å)