8GQ5

Human SARM1 bounded with NMN and Nanobody-C6, double-layer structure

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003690	molecular_function	double-stranded DNA binding
A	0003953	molecular_function	NAD+ nucleosidase activity
A	0005515	molecular_function	protein binding
A	0005737	cellular_component	cytoplasm
A	0005739	cellular_component	mitochondrion
A	0005829	cellular_component	cytosol
A	0005874	cellular_component	microtubule
A	0007165	biological_process	signal transduction
A	0019677	biological_process	NAD+ catabolic process
A	0030424	cellular_component	axon
A	0030425	cellular_component	dendrite
A	0034128	biological_process	negative regulation of MyD88-independent toll-like receptor signaling pathway
A	0035591	molecular_function	signaling adaptor activity
A	0043025	cellular_component	neuronal cell body
A	0043068	biological_process	positive regulation of programmed cell death
A	0045202	cellular_component	synapse
A	0048678	biological_process	response to axon injury
A	0048814	biological_process	regulation of dendrite morphogenesis
A	0050135	molecular_function	NADP+ nucleosidase activity
A	0050877	biological_process	nervous system process
A	0061809	molecular_function	NAD+ nucleosidase activity, cyclic ADP-ribose generating
A	0070585	biological_process	protein localization to mitochondrion
B	0003690	molecular_function	double-stranded DNA binding
B	0003953	molecular_function	NAD+ nucleosidase activity
B	0005515	molecular_function	protein binding
B	0005737	cellular_component	cytoplasm
B	0005739	cellular_component	mitochondrion
B	0005829	cellular_component	cytosol
B	0005874	cellular_component	microtubule
B	0007165	biological_process	signal transduction
B	0019677	biological_process	NAD+ catabolic process
B	0030424	cellular_component	axon
B	0030425	cellular_component	dendrite
B	0034128	biological_process	negative regulation of MyD88-independent toll-like receptor signaling pathway
B	0035591	molecular_function	signaling adaptor activity
B	0043025	cellular_component	neuronal cell body
B	0043068	biological_process	positive regulation of programmed cell death
B	0045202	cellular_component	synapse
B	0048678	biological_process	response to axon injury
B	0048814	biological_process	regulation of dendrite morphogenesis
B	0050135	molecular_function	NADP+ nucleosidase activity
B	0050877	biological_process	nervous system process
B	0061809	molecular_function	NAD+ nucleosidase activity, cyclic ADP-ribose generating
B	0070585	biological_process	protein localization to mitochondrion
C	0003690	molecular_function	double-stranded DNA binding
C	0003953	molecular_function	NAD+ nucleosidase activity
C	0005515	molecular_function	protein binding
C	0005737	cellular_component	cytoplasm
C	0005739	cellular_component	mitochondrion
C	0005829	cellular_component	cytosol
C	0005874	cellular_component	microtubule
C	0007165	biological_process	signal transduction
C	0019677	biological_process	NAD+ catabolic process
C	0030424	cellular_component	axon
C	0030425	cellular_component	dendrite
C	0034128	biological_process	negative regulation of MyD88-independent toll-like receptor signaling pathway
C	0035591	molecular_function	signaling adaptor activity
C	0043025	cellular_component	neuronal cell body
C	0043068	biological_process	positive regulation of programmed cell death
C	0045202	cellular_component	synapse
C	0048678	biological_process	response to axon injury
C	0048814	biological_process	regulation of dendrite morphogenesis
C	0050135	molecular_function	NADP+ nucleosidase activity
C	0050877	biological_process	nervous system process
C	0061809	molecular_function	NAD+ nucleosidase activity, cyclic ADP-ribose generating
C	0070585	biological_process	protein localization to mitochondrion
D	0003690	molecular_function	double-stranded DNA binding
D	0003953	molecular_function	NAD+ nucleosidase activity
D	0005515	molecular_function	protein binding
D	0005737	cellular_component	cytoplasm
D	0005739	cellular_component	mitochondrion
D	0005829	cellular_component	cytosol
D	0005874	cellular_component	microtubule
D	0007165	biological_process	signal transduction
D	0019677	biological_process	NAD+ catabolic process
D	0030424	cellular_component	axon
D	0030425	cellular_component	dendrite
D	0034128	biological_process	negative regulation of MyD88-independent toll-like receptor signaling pathway
D	0035591	molecular_function	signaling adaptor activity
D	0043025	cellular_component	neuronal cell body
D	0043068	biological_process	positive regulation of programmed cell death
D	0045202	cellular_component	synapse
D	0048678	biological_process	response to axon injury
D	0048814	biological_process	regulation of dendrite morphogenesis
D	0050135	molecular_function	NADP+ nucleosidase activity
D	0050877	biological_process	nervous system process
D	0061809	molecular_function	NAD+ nucleosidase activity, cyclic ADP-ribose generating
D	0070585	biological_process	protein localization to mitochondrion
E	0003690	molecular_function	double-stranded DNA binding
E	0003953	molecular_function	NAD+ nucleosidase activity
E	0005515	molecular_function	protein binding
E	0005737	cellular_component	cytoplasm
E	0005739	cellular_component	mitochondrion
E	0005829	cellular_component	cytosol
E	0005874	cellular_component	microtubule
E	0007165	biological_process	signal transduction
E	0019677	biological_process	NAD+ catabolic process
E	0030424	cellular_component	axon
E	0030425	cellular_component	dendrite
E	0034128	biological_process	negative regulation of MyD88-independent toll-like receptor signaling pathway
E	0035591	molecular_function	signaling adaptor activity
E	0043025	cellular_component	neuronal cell body
E	0043068	biological_process	positive regulation of programmed cell death
E	0045202	cellular_component	synapse
E	0048678	biological_process	response to axon injury
E	0048814	biological_process	regulation of dendrite morphogenesis
E	0050135	molecular_function	NADP+ nucleosidase activity
E	0050877	biological_process	nervous system process
E	0061809	molecular_function	NAD+ nucleosidase activity, cyclic ADP-ribose generating
E	0070585	biological_process	protein localization to mitochondrion
F	0003690	molecular_function	double-stranded DNA binding
F	0003953	molecular_function	NAD+ nucleosidase activity
F	0005515	molecular_function	protein binding
F	0005737	cellular_component	cytoplasm
F	0005739	cellular_component	mitochondrion
F	0005829	cellular_component	cytosol
F	0005874	cellular_component	microtubule
F	0007165	biological_process	signal transduction
F	0019677	biological_process	NAD+ catabolic process
F	0030424	cellular_component	axon
F	0030425	cellular_component	dendrite
F	0034128	biological_process	negative regulation of MyD88-independent toll-like receptor signaling pathway
F	0035591	molecular_function	signaling adaptor activity
F	0043025	cellular_component	neuronal cell body
F	0043068	biological_process	positive regulation of programmed cell death
F	0045202	cellular_component	synapse
F	0048678	biological_process	response to axon injury
F	0048814	biological_process	regulation of dendrite morphogenesis
F	0050135	molecular_function	NADP+ nucleosidase activity
F	0050877	biological_process	nervous system process
F	0061809	molecular_function	NAD+ nucleosidase activity, cyclic ADP-ribose generating
F	0070585	biological_process	protein localization to mitochondrion
G	0003690	molecular_function	double-stranded DNA binding
G	0003953	molecular_function	NAD+ nucleosidase activity
G	0005515	molecular_function	protein binding
G	0005737	cellular_component	cytoplasm
G	0005739	cellular_component	mitochondrion
G	0005829	cellular_component	cytosol
G	0005874	cellular_component	microtubule
G	0007165	biological_process	signal transduction
G	0019677	biological_process	NAD+ catabolic process
G	0030424	cellular_component	axon
G	0030425	cellular_component	dendrite
G	0034128	biological_process	negative regulation of MyD88-independent toll-like receptor signaling pathway
G	0035591	molecular_function	signaling adaptor activity
G	0043025	cellular_component	neuronal cell body
G	0043068	biological_process	positive regulation of programmed cell death
G	0045202	cellular_component	synapse
G	0048678	biological_process	response to axon injury
G	0048814	biological_process	regulation of dendrite morphogenesis
G	0050135	molecular_function	NADP+ nucleosidase activity
G	0050877	biological_process	nervous system process
G	0061809	molecular_function	NAD+ nucleosidase activity, cyclic ADP-ribose generating
G	0070585	biological_process	protein localization to mitochondrion
H	0003690	molecular_function	double-stranded DNA binding
H	0003953	molecular_function	NAD+ nucleosidase activity
H	0005515	molecular_function	protein binding
H	0005737	cellular_component	cytoplasm
H	0005739	cellular_component	mitochondrion
H	0005829	cellular_component	cytosol
H	0005874	cellular_component	microtubule
H	0007165	biological_process	signal transduction
H	0019677	biological_process	NAD+ catabolic process
H	0030424	cellular_component	axon
H	0030425	cellular_component	dendrite
H	0034128	biological_process	negative regulation of MyD88-independent toll-like receptor signaling pathway
H	0035591	molecular_function	signaling adaptor activity
H	0043025	cellular_component	neuronal cell body
H	0043068	biological_process	positive regulation of programmed cell death
H	0045202	cellular_component	synapse
H	0048678	biological_process	response to axon injury
H	0048814	biological_process	regulation of dendrite morphogenesis
H	0050135	molecular_function	NADP+ nucleosidase activity
H	0050877	biological_process	nervous system process
H	0061809	molecular_function	NAD+ nucleosidase activity, cyclic ADP-ribose generating
H	0070585	biological_process	protein localization to mitochondrion
I	0003690	molecular_function	double-stranded DNA binding
I	0003953	molecular_function	NAD+ nucleosidase activity
I	0005515	molecular_function	protein binding
I	0005737	cellular_component	cytoplasm
I	0005739	cellular_component	mitochondrion
I	0005829	cellular_component	cytosol
I	0005874	cellular_component	microtubule
I	0007165	biological_process	signal transduction
I	0019677	biological_process	NAD+ catabolic process
I	0030424	cellular_component	axon
I	0030425	cellular_component	dendrite
I	0034128	biological_process	negative regulation of MyD88-independent toll-like receptor signaling pathway
I	0035591	molecular_function	signaling adaptor activity
I	0043025	cellular_component	neuronal cell body
I	0043068	biological_process	positive regulation of programmed cell death
I	0045202	cellular_component	synapse
I	0048678	biological_process	response to axon injury
I	0048814	biological_process	regulation of dendrite morphogenesis
I	0050135	molecular_function	NADP+ nucleosidase activity
I	0050877	biological_process	nervous system process
I	0061809	molecular_function	NAD+ nucleosidase activity, cyclic ADP-ribose generating
I	0070585	biological_process	protein localization to mitochondrion
J	0003690	molecular_function	double-stranded DNA binding
J	0003953	molecular_function	NAD+ nucleosidase activity
J	0005515	molecular_function	protein binding
J	0005737	cellular_component	cytoplasm
J	0005739	cellular_component	mitochondrion
J	0005829	cellular_component	cytosol
J	0005874	cellular_component	microtubule
J	0007165	biological_process	signal transduction
J	0019677	biological_process	NAD+ catabolic process
J	0030424	cellular_component	axon
J	0030425	cellular_component	dendrite
J	0034128	biological_process	negative regulation of MyD88-independent toll-like receptor signaling pathway
J	0035591	molecular_function	signaling adaptor activity
J	0043025	cellular_component	neuronal cell body
J	0043068	biological_process	positive regulation of programmed cell death
J	0045202	cellular_component	synapse
J	0048678	biological_process	response to axon injury
J	0048814	biological_process	regulation of dendrite morphogenesis
J	0050135	molecular_function	NADP+ nucleosidase activity
J	0050877	biological_process	nervous system process
J	0061809	molecular_function	NAD+ nucleosidase activity, cyclic ADP-ribose generating
J	0070585	biological_process	protein localization to mitochondrion
K	0003690	molecular_function	double-stranded DNA binding
K	0003953	molecular_function	NAD+ nucleosidase activity
K	0005515	molecular_function	protein binding
K	0005737	cellular_component	cytoplasm
K	0005739	cellular_component	mitochondrion
K	0005829	cellular_component	cytosol
K	0005874	cellular_component	microtubule
K	0007165	biological_process	signal transduction
K	0019677	biological_process	NAD+ catabolic process
K	0030424	cellular_component	axon
K	0030425	cellular_component	dendrite
K	0034128	biological_process	negative regulation of MyD88-independent toll-like receptor signaling pathway
K	0035591	molecular_function	signaling adaptor activity
K	0043025	cellular_component	neuronal cell body
K	0043068	biological_process	positive regulation of programmed cell death
K	0045202	cellular_component	synapse
K	0048678	biological_process	response to axon injury
K	0048814	biological_process	regulation of dendrite morphogenesis
K	0050135	molecular_function	NADP+ nucleosidase activity
K	0050877	biological_process	nervous system process
K	0061809	molecular_function	NAD+ nucleosidase activity, cyclic ADP-ribose generating
K	0070585	biological_process	protein localization to mitochondrion
L	0003690	molecular_function	double-stranded DNA binding
L	0003953	molecular_function	NAD+ nucleosidase activity
L	0005515	molecular_function	protein binding
L	0005737	cellular_component	cytoplasm
L	0005739	cellular_component	mitochondrion
L	0005829	cellular_component	cytosol
L	0005874	cellular_component	microtubule
L	0007165	biological_process	signal transduction
L	0019677	biological_process	NAD+ catabolic process
L	0030424	cellular_component	axon
L	0030425	cellular_component	dendrite
L	0034128	biological_process	negative regulation of MyD88-independent toll-like receptor signaling pathway
L	0035591	molecular_function	signaling adaptor activity
L	0043025	cellular_component	neuronal cell body
L	0043068	biological_process	positive regulation of programmed cell death
L	0045202	cellular_component	synapse
L	0048678	biological_process	response to axon injury
L	0048814	biological_process	regulation of dendrite morphogenesis
L	0050135	molecular_function	NADP+ nucleosidase activity
L	0050877	biological_process	nervous system process
L	0061809	molecular_function	NAD+ nucleosidase activity, cyclic ADP-ribose generating
L	0070585	biological_process	protein localization to mitochondrion
M	0003690	molecular_function	double-stranded DNA binding
M	0003953	molecular_function	NAD+ nucleosidase activity
M	0005515	molecular_function	protein binding
M	0005737	cellular_component	cytoplasm
M	0005739	cellular_component	mitochondrion
M	0005829	cellular_component	cytosol
M	0005874	cellular_component	microtubule
M	0007165	biological_process	signal transduction
M	0019677	biological_process	NAD+ catabolic process
M	0030424	cellular_component	axon
M	0030425	cellular_component	dendrite
M	0034128	biological_process	negative regulation of MyD88-independent toll-like receptor signaling pathway
M	0035591	molecular_function	signaling adaptor activity
M	0043025	cellular_component	neuronal cell body
M	0043068	biological_process	positive regulation of programmed cell death
M	0045202	cellular_component	synapse
M	0048678	biological_process	response to axon injury
M	0048814	biological_process	regulation of dendrite morphogenesis
M	0050135	molecular_function	NADP+ nucleosidase activity
M	0050877	biological_process	nervous system process
M	0061809	molecular_function	NAD+ nucleosidase activity, cyclic ADP-ribose generating
M	0070585	biological_process	protein localization to mitochondrion
N	0003690	molecular_function	double-stranded DNA binding
N	0003953	molecular_function	NAD+ nucleosidase activity
N	0005515	molecular_function	protein binding
N	0005737	cellular_component	cytoplasm
N	0005739	cellular_component	mitochondrion
N	0005829	cellular_component	cytosol
N	0005874	cellular_component	microtubule
N	0007165	biological_process	signal transduction
N	0019677	biological_process	NAD+ catabolic process
N	0030424	cellular_component	axon
N	0030425	cellular_component	dendrite
N	0034128	biological_process	negative regulation of MyD88-independent toll-like receptor signaling pathway
N	0035591	molecular_function	signaling adaptor activity
N	0043025	cellular_component	neuronal cell body
N	0043068	biological_process	positive regulation of programmed cell death
N	0045202	cellular_component	synapse
N	0048678	biological_process	response to axon injury
N	0048814	biological_process	regulation of dendrite morphogenesis
N	0050135	molecular_function	NADP+ nucleosidase activity
N	0050877	biological_process	nervous system process
N	0061809	molecular_function	NAD+ nucleosidase activity, cyclic ADP-ribose generating
N	0070585	biological_process	protein localization to mitochondrion
O	0003690	molecular_function	double-stranded DNA binding
O	0003953	molecular_function	NAD+ nucleosidase activity
O	0005515	molecular_function	protein binding
O	0005737	cellular_component	cytoplasm
O	0005739	cellular_component	mitochondrion
O	0005829	cellular_component	cytosol
O	0005874	cellular_component	microtubule
O	0007165	biological_process	signal transduction
O	0019677	biological_process	NAD+ catabolic process
O	0030424	cellular_component	axon
O	0030425	cellular_component	dendrite
O	0034128	biological_process	negative regulation of MyD88-independent toll-like receptor signaling pathway
O	0035591	molecular_function	signaling adaptor activity
O	0043025	cellular_component	neuronal cell body
O	0043068	biological_process	positive regulation of programmed cell death
O	0045202	cellular_component	synapse
O	0048678	biological_process	response to axon injury
O	0048814	biological_process	regulation of dendrite morphogenesis
O	0050135	molecular_function	NADP+ nucleosidase activity
O	0050877	biological_process	nervous system process
O	0061809	molecular_function	NAD+ nucleosidase activity, cyclic ADP-ribose generating
O	0070585	biological_process	protein localization to mitochondrion
P	0003690	molecular_function	double-stranded DNA binding
P	0003953	molecular_function	NAD+ nucleosidase activity
P	0005515	molecular_function	protein binding
P	0005737	cellular_component	cytoplasm
P	0005739	cellular_component	mitochondrion
P	0005829	cellular_component	cytosol
P	0005874	cellular_component	microtubule
P	0007165	biological_process	signal transduction
P	0019677	biological_process	NAD+ catabolic process
P	0030424	cellular_component	axon
P	0030425	cellular_component	dendrite
P	0034128	biological_process	negative regulation of MyD88-independent toll-like receptor signaling pathway
P	0035591	molecular_function	signaling adaptor activity
P	0043025	cellular_component	neuronal cell body
P	0043068	biological_process	positive regulation of programmed cell death
P	0045202	cellular_component	synapse
P	0048678	biological_process	response to axon injury
P	0048814	biological_process	regulation of dendrite morphogenesis
P	0050135	molecular_function	NADP+ nucleosidase activity
P	0050877	biological_process	nervous system process
P	0061809	molecular_function	NAD+ nucleosidase activity, cyclic ADP-ribose generating
P	0070585	biological_process	protein localization to mitochondrion

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	688
Details	Repeat: {"description":"ARM 8","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	1024
Details	Domain: {"description":"SAM 1","evidences":[{"source":"PROSITE-ProRule","id":"PRU00184","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	992
Details	Domain: {"description":"SAM 2","evidences":[{"source":"PROSITE-ProRule","id":"PRU00184","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	16
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"30333228","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---