8ALY
Cryo-EM structure of human tankyrase 2 SAM-PARP filament (G1032W mutant)
Summary for 8ALY
Entry DOI | 10.2210/pdb8aly/pdb |
EMDB information | 15520 |
Descriptor | Poly [ADP-ribose] polymerase tankyrase-2, ZINC ION (2 entities in total) |
Functional Keywords | poly-adp-ribosyltransferase, enzyme, polymer, signaling protein |
Biological source | Homo sapiens (human) |
Total number of polymer chains | 20 |
Total formula weight | 682861.54 |
Authors | Mariotti, L.,Inian, O.,Desfosses, A.,Beuron, F.,Morris, E.P.,Guettler, S. (deposition date: 2022-08-01, release date: 2022-11-16, Last modification date: 2024-07-24) |
Primary citation | Pillay, N.,Mariotti, L.,Zaleska, M.,Inian, O.,Jessop, M.,Hibbs, S.,Desfosses, A.,Hopkins, P.C.R.,Templeton, C.M.,Beuron, F.,Morris, E.P.,Guettler, S. Structural basis of tankyrase activation by polymerization. Nature, 612:162-169, 2022 Cited by PubMed: 36418402DOI: 10.1038/s41586-022-05449-8 PDB entries with the same primary citation |
Experimental method | ELECTRON MICROSCOPY (2.98 Å) |
Structure validation
Download full validation report