7L1U
| Orexin Receptor 2 (OX2R) in Complex with G Protein and Natural Peptide-Agonist Orexin B (OxB) | 分子名称: | Engineered Guanine nucleotide-binding protein subunit alpha, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | 著者 | Hong, C, Byrne, N.J, Zamlynny, B, Tummala, S, Xiao, L, Shipman, J.M, Partridge, A.T, Minnick, C, Breslin, M.J, Rudd, M.T, Stachel, S.J, Rada, V.L, Kern, J.C, Armacost, K.A, Hollingsworth, S.A, O'Brien, J.A, Hall, D.L, McDonald, T.P, Strickland, C, Brooun, A, Soisson, S.M, Hollenstein, K. | 登録日 | 2020-12-15 | 公開日 | 2021-02-10 | 最終更新日 | 2021-02-17 | 実験手法 | ELECTRON MICROSCOPY (3.2 Å) | 主引用文献 | Structures of active-state orexin receptor 2 rationalize peptide and small-molecule agonist recognition and receptor activation. Nat Commun, 12, 2021
|
|
7L1V
| Orexin Receptor 2 (OX2R) in Complex with G Protein and Small-Molecule Agonist Compound 1 | 分子名称: | 4'-methoxy-N,N-dimethyl-3'-{[3-(2-{[2-(2H-1,2,3-triazol-2-yl)benzene-1-carbonyl]amino}ethyl)phenyl]sulfamoyl}[1,1'-biphenyl]-3-carboxamide, Engineered Guanine nucleotide-binding protein subunit alpha, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... | 著者 | Hong, C, Byrne, N.J, Zamlynny, B, Tummala, S, Xiao, L, Shipman, J.M, Partridge, A.T, Minnick, C, Breslin, M.J, Rudd, M.T, Stachel, S.J, Rada, V.L, Kern, J.C, Armacost, K.A, Hollingsworth, S.A, O'Brien, J.A, Hall, D.L, McDonald, T.P, Strickland, C, Brooun, A, Soisson, S.M, Hollenstein, K. | 登録日 | 2020-12-15 | 公開日 | 2021-02-10 | 最終更新日 | 2021-02-17 | 実験手法 | ELECTRON MICROSCOPY (3 Å) | 主引用文献 | Structures of active-state orexin receptor 2 rationalize peptide and small-molecule agonist recognition and receptor activation. Nat Commun, 12, 2021
|
|
7KH0
| Cryo-EM structure of the human arginine vasopressin AVP-vasopressin receptor V2R-Gs signaling complex | 分子名称: | Arg-vasopressin, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | 著者 | Wang, L, Xu, J, Gao, S, Sun, D, Liu, H, Liu, Z, Du, Y, Zhang, C. | 登録日 | 2020-10-19 | 公開日 | 2021-05-26 | 最終更新日 | 2023-03-29 | 実験手法 | ELECTRON MICROSCOPY (2.8 Å) | 主引用文献 | Cryo-EM structure of the AVP-vasopressin receptor 2-G s signaling complex. Cell Res., 31, 2021
|
|
7KI1
| Taspoglutide-bound Glucagon-Like Peptide-1 (GLP-1) Receptor in Complex with Gs Protein | 分子名称: | Glucagon-like peptide 1 receptor, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | 著者 | Zhang, X, Belousoff, M.J, Danev, R, Sexton, P.M, Wootten, D. | 登録日 | 2020-10-22 | 公開日 | 2021-08-04 | 実験手法 | ELECTRON MICROSCOPY (2.5 Å) | 主引用文献 | Structure and dynamics of semaglutide- and taspoglutide-bound GLP-1R-Gs complexes. Cell Rep, 36, 2021
|
|
7KI0
| Semaglutide-bound Glucagon-Like Peptide-1 (GLP-1) Receptor in Complex with Gs protein | 分子名称: | 17-amino-10-oxo-3,6,12,15-tetraoxa-9-azaheptadecan-1-oic acid, Glucagon-like peptide 1 receptor, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... | 著者 | Zhang, X, Belousoff, M.J, Danev, R, Sexton, P.M, Wootten, D. | 登録日 | 2020-10-22 | 公開日 | 2021-08-04 | 実験手法 | ELECTRON MICROSCOPY (2.5 Å) | 主引用文献 | Structure and dynamics of semaglutide- and taspoglutide-bound GLP-1R-Gs complexes. Cell Rep, 36, 2021
|
|
7LCI
| PF 06882961 bound to the glucagon-like peptide-1 receptor (GLP-1R):Gs complex | 分子名称: | 2-[(4-{6-[(4-cyano-2-fluorophenyl)methoxy]pyridin-2-yl}piperidin-1-yl)methyl]-1-{[(2S)-oxetan-2-yl]methyl}-1H-benzimidazole-6-carboxylic acid, Glucagon-like peptide 1 receptor, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... | 著者 | Belousoff, M.J, Johnson, R.M, Drulyte, I, Yu, L, Kotecha, A, Danev, R, Wootten, D, Zhang, X, Sexton, P.M. | 登録日 | 2021-01-11 | 公開日 | 2021-01-20 | 最終更新日 | 2021-09-15 | 実験手法 | ELECTRON MICROSCOPY (2.9 Å) | 主引用文献 | Evolving cryo-EM structural approaches for GPCR drug discovery. Structure, 29, 2021
|
|
7LJC
| Allosteric modulator LY3154207 binding to SKF-81297-bound dopamine receptor 1 in complex with miniGs protein | 分子名称: | (1R)-6-chloro-1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepine-7,8-diol, 2-[2,6-bis(chloranyl)phenyl]-1-[(1S,3R)-3-(hydroxymethyl)-1-methyl-5-(3-methyl-3-oxidanyl-butyl)-3,4-dihydro-1H-isoquinolin-2-yl]ethanone, CHOLESTEROL, ... | 著者 | Zhuang, Y, Krumm, B, Zhang, H, Zhou, X.E, Wang, Y, Guo, J, Huang, X.-P, Liu, Y, Wang, L, Cheng, X, Jiang, Y, Jiang, H, Melcher, K, Zhang, C, Yi, W, Roth, B.L, Zhang, Y, Xu, H.E. | 登録日 | 2021-01-28 | 公開日 | 2021-03-03 | 最終更新日 | 2021-05-12 | 実験手法 | ELECTRON MICROSCOPY (3 Å) | 主引用文献 | Mechanism of dopamine binding and allosteric modulation of the human D1 dopamine receptor. Cell Res., 31, 2021
|
|
7LJD
| Allosteric modulator LY3154207 binding to dopamine-bound dopamine receptor 1 in complex with miniGs protein | 分子名称: | 2-[2,6-bis(chloranyl)phenyl]-1-[(1S,3R)-3-(hydroxymethyl)-1-methyl-5-(3-methyl-3-oxidanyl-butyl)-3,4-dihydro-1H-isoquinolin-2-yl]ethanone, CHOLESTEROL, D(1A) dopamine receptor, ... | 著者 | Zhuang, Y, Krumm, B, Zhang, H, Zhou, X.E, Wang, Y, Guo, J, Huang, X.-P, Liu, Y, Wang, L, Cheng, X, Jiang, Y, Jiang, H, Melcher, K, Zhang, C, Yi, W, Roth, B.L, Zhang, Y, Xu, H.E. | 登録日 | 2021-01-28 | 公開日 | 2021-03-03 | 最終更新日 | 2021-05-12 | 実験手法 | ELECTRON MICROSCOPY (3.2 Å) | 主引用文献 | Mechanism of dopamine binding and allosteric modulation of the human D1 dopamine receptor. Cell Res., 31, 2021
|
|
7LD4
| Cryo-EM structure of the human adenosine A1 receptor-Gi2-protein complex bound to its endogenous agonist | 分子名称: | ADENOSINE, Chimera protein of Muscarinic acetylcholine receptor M4 and Adenosine receptor A1, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... | 著者 | Draper-Joyce, C.J, Danev, R, Thal, D.M, Christopoulos, A, Glukhova, A. | 登録日 | 2021-01-12 | 公開日 | 2021-09-08 | 最終更新日 | 2021-10-13 | 実験手法 | ELECTRON MICROSCOPY (3.3 Å) | 主引用文献 | Positive allosteric mechanisms of adenosine A 1 receptor-mediated analgesia. Nature, 597, 2021
|
|
7LD3
| Cryo-EM structure of the human adenosine A1 receptor-Gi2-protein complex bound to its endogenous agonist and an allosteric ligand | 分子名称: | ADENOSINE, Chimera protein of Muscarinic acetylcholine receptor M4 and Adenosine receptor A1, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... | 著者 | Draper-Joyce, C.J, Danev, R, Thal, D.M, Christopoulos, A, Glukhova, A. | 登録日 | 2021-01-12 | 公開日 | 2021-09-08 | 最終更新日 | 2021-10-13 | 実験手法 | ELECTRON MICROSCOPY (3.2 Å) | 主引用文献 | Positive allosteric mechanisms of adenosine A 1 receptor-mediated analgesia. Nature, 597, 2021
|
|
7LLY
| Oxyntomodulin-bound Glucagon-Like Peptide-1 (GLP-1) Receptor in complex with Gs protein | 分子名称: | Glucagon-like peptide 1 receptor, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | 著者 | Wootten, D, Sexton, P.M, Belousoff, M.J, Danev, R, Zhang, X, Khoshouei, M, Venugopal, H. | 登録日 | 2021-02-04 | 公開日 | 2022-01-12 | 最終更新日 | 2022-01-26 | 実験手法 | ELECTRON MICROSCOPY (3.3 Å) | 主引用文献 | Dynamics of GLP-1R peptide agonist engagement are correlated with kinetics of G protein activation. Nat Commun, 13, 2022
|
|
7LLL
| Exendin-4-bound Glucagon-Like Peptide-1 (GLP-1) Receptor in complex with Gs protein | 分子名称: | Exendin-4, Glucagon-like peptide 1 receptor, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... | 著者 | Wootten, D, Sexton, P.M, Belousoff, M.J, Danev, R, Zhang, X, Khoshouei, M, Venugopal, H. | 登録日 | 2021-02-04 | 公開日 | 2022-01-12 | 最終更新日 | 2022-01-26 | 実験手法 | ELECTRON MICROSCOPY (3.7 Å) | 主引用文献 | Dynamics of GLP-1R peptide agonist engagement are correlated with kinetics of G protein activation. Nat Commun, 13, 2022
|
|
7MBX
| Human Cholecystokinin 1 receptor (CCK1R) Gs complex | 分子名称: | CHOLESTEROL HEMISUCCINATE, Cholecystokinin receptor type A, Cholecystokinin-8, ... | 著者 | Mobbs, J.I, Belousoff, M.J, Danev, R, Thal, D.M, Sexton, P.M. | 登録日 | 2021-04-01 | 公開日 | 2021-05-26 | 最終更新日 | 2021-07-14 | 実験手法 | ELECTRON MICROSCOPY (1.95 Å) | 主引用文献 | Structures of the human cholecystokinin 1 (CCK1) receptor bound to Gs and Gq mimetic proteins provide insight into mechanisms of G protein selectivity. Plos Biol., 19, 2021
|
|
7MBY
| Human Cholecystokinin 1 receptor (CCK1R) Gq chimera (mGsqi) complex | 分子名称: | CHOLESTEROL HEMISUCCINATE, Cholecystokinin receptor type A, Cholecystokinin-8, ... | 著者 | Mobbs, J.I, Belousoff, M.J, Danev, R, Thal, D.M, Sexton, P.M. | 登録日 | 2021-04-01 | 公開日 | 2021-05-26 | 最終更新日 | 2021-07-14 | 実験手法 | ELECTRON MICROSCOPY (2.44 Å) | 主引用文献 | Structures of the human cholecystokinin 1 (CCK1) receptor bound to Gs and Gq mimetic proteins provide insight into mechanisms of G protein selectivity. Plos Biol., 19, 2021
|
|
7MTS
| CryoEM Structure of mGlu2 - Gi Complex | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-methoxy-6-propyl-N-(2-{4-[(1H-tetrazol-5-yl)methoxy]phenyl}ethyl)thieno[2,3-d]pyrimidin-4-amine, GLUTAMIC ACID, ... | 著者 | Seven, A.B, Barros-Alvarez, X, Skiniotis, G. | 登録日 | 2021-05-13 | 公開日 | 2021-07-07 | 最終更新日 | 2021-07-28 | 実験手法 | ELECTRON MICROSCOPY (3.2 Å) | 主引用文献 | G-protein activation by a metabotropic glutamate receptor. Nature, 595, 2021
|
|
7XK8
| Cryo-EM structure of the Neuromedin U receptor 2 (NMUR2) in complex with G Protein and its endogeneous Peptide-Agonist NMU25 | 分子名称: | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(i) subunit alpha-1, ... | 著者 | Zhao, W, Wenru, Z, Mu, W, Minmin, L, Shutian, C, Tingting, T, Gisela, S, Holger, W, Albert, B, Cuiying, Y, Xiaojing, C, Han, S, Wu, B, Zhao, Q. | 登録日 | 2022-04-19 | 公開日 | 2023-02-22 | 実験手法 | ELECTRON MICROSCOPY (3.3 Å) | 主引用文献 | Ligand recognition and activation of neuromedin U receptor 2. Nat Commun, 13, 2022
|
|
7XK2
| Cryo-EM Structure of Human Niacin Receptor HCA2-Gi protein complex | 分子名称: | 2-[[2,2-dimethyl-3-[3-(5-oxidanylpyridin-2-yl)-1,2,4-oxadiazol-5-yl]propanoyl]amino]cyclohexene-1-carboxylic acid, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | 著者 | Yang, Y, Kang, H.J, Gao, R.G, Wang, J.J, Han, G.W, DiBerto, J.F, Wu, L.J, Tong, J.H, Qu, L, Wu, Y.R, Pileski, R, Li, X.M, Zhang, X.C, Zhao, S.W, Kenakin, T, Wang, Q, Stevens, R.C, Peng, W, Roth, B.L, Rao, Z.H, Liu, Z.J. | 登録日 | 2022-04-19 | 公開日 | 2023-02-22 | 最終更新日 | 2023-12-06 | 実験手法 | ELECTRON MICROSCOPY (3.1 Å) | 主引用文献 | Structural insights into the human niacin receptor HCA2-G i signalling complex. Nat Commun, 14, 2023
|
|
7XJJ
| |
7Y35
| Cryo-EM structure of the Abaloparatide-bound human PTH1R-Gs complex | 分子名称: | Abaloparatide, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | 著者 | Zhai, X, Mao, C, Shen, Q, Zang, S, Shen, D, Zhang, H, Chen, Z, Wang, G, Zhang, C, Zhang, Y, Liu, Z. | 登録日 | 2022-06-09 | 公開日 | 2023-07-05 | 実験手法 | ELECTRON MICROSCOPY (2.9 Å) | 主引用文献 | Cryo-EM structure of the Abaloparatide-bound human PTH1R-Gs complex To Be Published
|
|
7Y36
| Cryo-EM structure of the Teriparatide-bound human PTH1R-Gs complex | 分子名称: | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, HYDROXIDE ION, ... | 著者 | Zhai, X, Mao, C, Shen, Q, Zang, S, Shen, D, Zhang, H, Chen, Z, Wang, G, Zhang, C, Zhang, Y, Liu, Z. | 登録日 | 2022-06-10 | 公開日 | 2023-07-05 | 実験手法 | ELECTRON MICROSCOPY (2.8 Å) | 主引用文献 | Cryo-EM structure of the Teriparatide-bound human PTH1R-Gs complex to be published
|
|
7Y12
| Cryo-EM structure of MrgD-Gi complex with beta-alanine | 分子名称: | BETA-ALANINE, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | 著者 | Suzuki, S, Iida, M, Kawamoto, A, Oshima, A. | 登録日 | 2022-06-06 | 公開日 | 2022-07-20 | 最終更新日 | 2023-02-15 | 実験手法 | ELECTRON MICROSCOPY (3.1 Å) | 主引用文献 | Structural insight into the activation mechanism of MrgD with heterotrimeric Gi-protein revealed by cryo-EM. Commun Biol, 5, 2022
|
|
7Y15
| Cryo-EM structure of apo-state MrgD-Gi complex | 分子名称: | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(i) subunit alpha-1, ... | 著者 | Suzuki, S, Iida, M, Kawamoto, A, Oshima, A. | 登録日 | 2022-06-06 | 公開日 | 2022-07-20 | 最終更新日 | 2022-11-23 | 実験手法 | ELECTRON MICROSCOPY (2.9 Å) | 主引用文献 | Structural insight into the activation mechanism of MrgD with heterotrimeric Gi-protein revealed by cryo-EM. Commun Biol, 5, 2022
|
|
7XT9
| Serotonin 4 (5-HT4) receptor-Gs complex | 分子名称: | CHOLESTEROL, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | 著者 | Huang, S, Xu, P, Shen, D.D, Simon, I.A, Mao, C, Tan, Y, Zhang, H, Harpsoe, K, Li, H, Zhang, Y, You, C, Yu, X, Jiang, Y, Zhang, Y, Gloriam, D.E, Xu, H.E. | 登録日 | 2022-05-16 | 公開日 | 2022-07-27 | 最終更新日 | 2022-08-03 | 実験手法 | ELECTRON MICROSCOPY (3.2 Å) | 主引用文献 | GPCRs steer G i and G s selectivity via TM5-TM6 switches as revealed by structures of serotonin receptors. Mol.Cell, 82, 2022
|
|
7XTA
| Serotonin 4 (5-HT4) receptor-Gi-scFv16 complex | 分子名称: | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(i) subunit alpha-1, ... | 著者 | Huang, S, Xu, P, Shen, D.D, Simon, I.A, Mao, C, Tan, Y, Zhang, H, Harpsoe, K, Li, H, Zhang, Y, You, C, Yu, X, Jiang, Y, Zhang, Y, Gloriam, D.E, Xu, H.E. | 登録日 | 2022-05-16 | 公開日 | 2022-07-27 | 最終更新日 | 2022-08-03 | 実験手法 | ELECTRON MICROSCOPY (3.2 Å) | 主引用文献 | GPCRs steer G i and G s selectivity via TM5-TM6 switches as revealed by structures of serotonin receptors. Mol.Cell, 82, 2022
|
|
7XTC
| Serotonin 7 (5-HT7) receptor-Gs-Nb35 complex | 分子名称: | 3-(2-azanylethyl)-1H-indole-5-carboxamide, CHOLESTEROL, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... | 著者 | Huang, S, Xu, P, Shen, D.D, Simon, I.A, Mao, C, Tan, Y, Zhang, H, Harpsoe, K, Li, H, Zhang, Y, You, C, Yu, X, Jiang, Y, Zhang, Y, Gloriam, D.E, Xu, H.E. | 登録日 | 2022-05-16 | 公開日 | 2022-07-27 | 最終更新日 | 2022-08-03 | 実験手法 | ELECTRON MICROSCOPY (3.2 Å) | 主引用文献 | GPCRs steer G i and G s selectivity via TM5-TM6 switches as revealed by structures of serotonin receptors. Mol.Cell, 82, 2022
|
|