7LJC

Allosteric modulator LY3154207 binding to SKF-81297-bound dopamine receptor 1 in complex with miniGs protein

Summary for 7LJC

• Entry DOI: 10.2210/pdb7ljc/pdb
• EMDB information: 23390
• Descriptor: D(1A) dopamine receptor, Engineered human Gs alpha subunit, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... (9 entities in total)
• Functional Keywords: dopamine receptor 2, gs protein, skf-81297, pam, ly3154207, signaling protein
• Biological source: Homo sapiens (Human); More
• Total number of polymer chains: 5
• Total formula weight: 150615.00

Authors

Zhuang, Y.,Krumm, B.,Zhang, H.,Zhou, X.E.,Wang, Y.,Guo, J.,Huang, X.-P.,Liu, Y.,Wang, L.,Cheng, X.,Jiang, Y.,Jiang, H.,Melcher, K.,Zhang, C.,Yi, W.,Roth, B.L.,Zhang, Y.,Xu, H.E. (deposition date: 2021-01-28, release date: 2021-03-03, Last modification date: 2021-05-12)

• Primary citation: Zhuang, Y.,Krumm, B.,Zhang, H.,Zhou, X.E.,Wang, Y.,Huang, X.P.,Liu, Y.,Cheng, X.,Jiang, Y.,Jiang, H.,Zhang, C.,Yi, W.,Roth, B.L.,Zhang, Y.,Xu, H.E.; Mechanism of dopamine binding and allosteric modulation of the human D1 dopamine receptor.; Cell Res., 31:593-596, 2021; PubMed: 33750903; DOI: 10.1038/s41422-021-00482-0

Experimental method

ELECTRON MICROSCOPY (3 Å)