8JZ7

Cryo-EM structure of MK-6892-bound HCAR2 in complex with Gi protein

Summary for 8JZ7

• Entry DOI: 10.2210/pdb8jz7/pdb
• EMDB information: 36736 36737 36738
• Descriptor: Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(i) subunit alpha-1, ... (6 entities in total)
• Functional Keywords: complex, agonist, membrane protein
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 5
• Total formula weight: 162474.24

Authors

Zhao, C.,Tian, X.W.,Liu, Y.,Cheng, L.,Yan, W.,Shao, Z.H. (deposition date: 2023-07-04, release date: 2023-10-04)

• Primary citation: Cheng, L.,Sun, S.,Wang, H.,Zhao, C.,Tian, X.,Liu, Y.,Fu, P.,Shao, Z.,Chai, R.,Yan, W.; Orthosteric ligand selectivity and allosteric probe dependence at Hydroxycarboxylic acid receptor HCAR2.; Signal Transduct Target Ther, 8:364-364, 2023; PubMed: 37743365; DOI: 10.1038/s41392-023-01625-y

Experimental method

ELECTRON MICROSCOPY (2.6 Å)