7L1U

Orexin Receptor 2 (OX2R) in Complex with G Protein and Natural Peptide-Agonist Orexin B (OxB)

Summary for 7L1U

• Entry DOI: 10.2210/pdb7l1u/pdb
• Related: 7L1V
• EMDB information: 23118 23119
• Descriptor: Engineered Guanine nucleotide-binding protein subunit alpha, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... (6 entities in total)
• Functional Keywords: class a gpcr, orexin receptor 2, ox2r, membrane protein, peptide agonist
• Biological source: Homo sapiens (Human); More
• Total number of polymer chains: 6
• Total formula weight: 147448.96

Authors

Hong, C.,Byrne, N.J.,Zamlynny, B.,Tummala, S.,Xiao, L.,Shipman, J.M.,Partridge, A.T.,Minnick, C.,Breslin, M.J.,Rudd, M.T.,Stachel, S.J.,Rada, V.L.,Kern, J.C.,Armacost, K.A.,Hollingsworth, S.A.,O'Brien, J.A.,Hall, D.L.,McDonald, T.P.,Strickland, C.,Brooun, A.,Soisson, S.M.,Hollenstein, K. (deposition date: 2020-12-15, release date: 2021-02-10, Last modification date: 2021-02-17)

• Primary citation: Hong, C.,Byrne, N.J.,Zamlynny, B.,Tummala, S.,Xiao, L.,Shipman, J.M.,Partridge, A.T.,Minnick, C.,Breslin, M.J.,Rudd, M.T.,Stachel, S.J.,Rada, V.L.,Kern, J.C.,Armacost, K.A.,Hollingsworth, S.A.,O'Brien, J.A.,Hall, D.L.,McDonald, T.P.,Strickland, C.,Brooun, A.,Soisson, S.M.,Hollenstein, K.; Structures of active-state orexin receptor 2 rationalize peptide and small-molecule agonist recognition and receptor activation.; Nat Commun, 12:815-815, 2021; PubMed: 33547286; DOI: 10.1038/s41467-021-21087-6

Experimental method

ELECTRON MICROSCOPY (3.2 Å)