PDB: 872 件ウェブページステータス検索Chemie searchBIRD

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6VCB	Cryo-EM structure of the Glucagon-like peptide-1 receptor in complex with G protein, GLP-1 peptide and a positive allosteric modulator 分子名称: 1-[(1R)-1-(2,6-dichloro-3-methoxyphenyl)ethyl]-6-{2-[(2R)-piperidin-2-yl]phenyl}-1H-benzimidazole, Glucagon-like peptide 1, Glucagon-like peptide 1 receptor, ... 著者 Sun, B, Feng, D, Bueno, A, Kobilka, B, Sloop, K. 登録日 2019-12-20 公開日 2020-07-22 最終更新日 2020-09-30 実験手法 ELECTRON MICROSCOPY (3.3 Å) 主引用文献 Structural insights into probe-dependent positive allosterism of the GLP-1 receptor. Nat.Chem.Biol., 16, 2020
6LML	Cryo-EM structure of the human glucagon receptor in complex with Gi1 分子名称: Glucagon, Glucagon receptor, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... 著者 Qiao, A, Han, S, Li, X, Sun, F, Zhao, Q, Wu, B. 登録日 2019-12-26 公開日 2020-04-01 実験手法 ELECTRON MICROSCOPY (3.9 Å) 主引用文献 Structural basis of Gsand Girecognition by the human glucagon receptor. Science, 367, 2020
6LMK	Cryo-EM structure of the human glucagon receptor in complex with Gs 分子名称: Glucagon, Glucagon receptor, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... 著者 Qiao, A, Han, S, Tai, L, Sun, F, Zhao, Q, Wu, B. 登録日 2019-12-26 公開日 2020-04-01 実験手法 ELECTRON MICROSCOPY (3.7 Å) 主引用文献 Structural basis of Gsand Girecognition by the human glucagon receptor. Science, 367, 2020
6LPB	Cryo-EM structure of the human PAC1 receptor coupled to an engineered heterotrimeric G protein 分子名称: Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(s) subunit alpha isoforms short,Guanine nucleotide-binding protein G(s) subunit alpha isoforms short, ... 著者 Kobayashi, K, Shihoya, W, Nishizawa, T, Nureki, O. 登録日 2020-01-09 公開日 2020-03-11 最終更新日 2020-03-25 実験手法 ELECTRON MICROSCOPY (3.9 Å) 主引用文献 Cryo-EM structure of the human PAC1 receptor coupled to an engineered heterotrimeric G protein. Nat.Struct.Mol.Biol., 27, 2020
6VMS	Structure of a D2 dopamine receptor-G-protein complex in a lipid membrane 分子名称: Endolysin,D(2) dopamine receptor,D(2) dopamine receptor, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... 著者 Yin, J, Chen, K.M, Clark, M.J, Hijazi, M, Kumari, P, Bai, X, Sunahara, R.K, Barth, P, Rosenbaum, D.M. 登録日 2020-01-28 公開日 2020-06-17 最終更新日 2020-08-19 実験手法 ELECTRON MICROSCOPY (3.8 Å) 主引用文献 Structure of a D2 dopamine receptor-G-protein complex in a lipid membrane. Nature, 584, 2020
6VN7	Cryo-EM structure of an activated VIP1 receptor-G protein complex 分子名称: CHOLESTEROL, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... 著者 Duan, J, Shen, D.-D, Zhou, X.E, Liu, Q.-F, Zhuang, Y.-W, Zhang, H.-B, Xu, P.-Y, Ma, S.-S, He, X.-H, Melcher, K, Zhang, Y, Xu, H.E, Yi, J. 登録日 2020-01-29 公開日 2020-09-02 実験手法 ELECTRON MICROSCOPY (3.2 Å) 主引用文献 Cryo-EM structure of an activated VIP1 receptor-G protein complex revealed by a NanoBiT tethering strategy. Nat Commun, 11, 2020
6VU5	Structure of G-alpha-q bound to its chaperone Ric-8A 分子名称: Guanine nucleotide-binding protein G(q) subunit alpha, Resistance to inhibitors of cholinesterase-8A (Ric-8A) 著者 Seven, A.B, Hilger, D. 登録日 2020-02-14 公開日 2020-03-18 最終更新日 2020-03-25 実験手法 ELECTRON MICROSCOPY (3.5 Å) 主引用文献 Structures of G alpha Proteins in Complex with Their Chaperone Reveal Quality Control Mechanisms. Cell Rep, 30, 2020
6VU8	Structure of G-alpha-i bound to its chaperone Ric-8A 分子名称: Guanine nucleotide-binding protein G(i) subunit alpha-1, Resistance to inhibitors of cholinesterase 8 homolog A (C. elegans) 著者 Seven, A.B, Hilger, D. 登録日 2020-02-14 公開日 2020-03-18 最終更新日 2020-03-25 実験手法 ELECTRON MICROSCOPY (4.14 Å) 主引用文献 Structures of G alpha Proteins in Complex with Their Chaperone Reveal Quality Control Mechanisms. Cell Rep, 30, 2020
6M1I	CryoEM structure of human PAC1 receptor in complex with PACAP38 分子名称: Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(s) subunit alpha isoforms short, ... 著者 Song, X, Wang, J, Zhang, D, Wang, H.W, Ma, Y. 登録日 2020-02-26 公開日 2020-03-11 最終更新日 2020-05-27 実験手法 ELECTRON MICROSCOPY (3.5 Å) 主引用文献 Cryo-EM structures of PAC1 receptor reveal ligand binding mechanism. Cell Res., 30, 2020
6M1H	CryoEM structure of human PAC1 receptor in complex with maxadilan 分子名称: Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(s) subunit alpha isoforms short, ... 著者 Song, X, Wang, J, Zhang, D, Wang, H.W, Ma, Y. 登録日 2020-02-26 公開日 2020-03-11 最終更新日 2020-05-27 実験手法 ELECTRON MICROSCOPY (3.6 Å) 主引用文献 Cryo-EM structures of PAC1 receptor reveal ligand binding mechanism. Cell Res., 30, 2020
7BPH	Crystal structure of GppNHp-bound GNAS in complex with the cyclic peptide inhibitor GN13 分子名称: CHLORIDE ION, GLYCEROL, GN13, ... 著者 Hu, Q, Dai, S, Shokat, K.M. 登録日 2020-03-22 公開日 2021-03-31 最終更新日 2023-11-29 実験手法 X-RAY DIFFRACTION (1.57 Å) 主引用文献 State-selective modulation of heterotrimeric G alpha s signaling with macrocyclic peptides. Cell, 2022
6WHC	CryoEM Structure of the glucagon receptor with a dual-agonist peptide 分子名称: Dual-agonist peptide, Glucagon receptor, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... 著者 Belousoff, M.J, Sexton, P, Danev, R. 登録日 2020-04-07 公開日 2020-05-27 最終更新日 2020-07-22 実験手法 ELECTRON MICROSCOPY (3.4 Å) 主引用文献 Cryo-electron microscopy structure of the glucagon receptor with a dual-agonist peptide. J.Biol.Chem., 295, 2020
6WI9	Human secretin receptor Gs complex 分子名称: Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(s) subunit alpha isoforms short, ... 著者 Belousoff, M.J, Khoshouei, M. 登録日 2020-04-09 公開日 2020-08-12 最終更新日 2020-09-02 実験手法 ELECTRON MICROSCOPY (4.3 Å) 主引用文献 Structure and dynamics of the active Gs-coupled human secretin receptor. Nat Commun, 11, 2020
7BW0	Active human TGR5 complex with a synthetic agonist 23H 分子名称: Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(s) subunit alpha isoforms short,Guanine nucleotide-binding protein G(s) subunit alpha isoforms short, ... 著者 Chen, G, Wang, X.K, Chen, Q, Hu, H.L, Ren, R.B. 登録日 2020-04-12 公開日 2020-09-02 最終更新日 2024-03-27 実験手法 ELECTRON MICROSCOPY (3.9 Å) 主引用文献 Cryo-EM structure of activated bile acids receptor TGR5 in complex with stimulatory G protein. Signal Transduct Target Ther, 5, 2020
7BZ2	Cryo-EM structure of the formoterol-bound beta2 adrenergic receptor-Gs protein complex. 分子名称: Beta2 adrenergic receptor, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... 著者 Zhang, Y.N, Yang, F, Ling, S.L, Lv, P, Zhou, Y.X, Fang, W, Sun, W, Shi, P, Tian, C.L. 登録日 2020-04-26 公開日 2020-08-05 実験手法 ELECTRON MICROSCOPY (3.82 Å) 主引用文献 Single-particle cryo-EM structural studies of the beta2AR-Gs complex bound with a full agonist formoterol. Cell Discov, 6, 2020
6WPW	GCGR-Gs signaling complex bound to a designed glucagon derivative 分子名称: Glucagon derivative ZP3780, Glucagon receptor, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... 著者 Hilger, D, Krishna Kumar, K, Hu, H, Mathiesen, J.M, Skiniotis, G, Kobilka, B.K. 登録日 2020-04-28 公開日 2020-08-12 実験手法 ELECTRON MICROSCOPY (3.1 Å) 主引用文献 Structural insights into differences in G protein activation by family A and family B GPCRs. Science, 369, 2020
7C2E	GLP-1R-Gs complex structure with a small molecule full agonist 分子名称: 2-[[4-[6-[(4-cyano-2-fluoranyl-phenyl)methoxy]pyridin-2-yl]-3,6-dihydro-2~{H}-pyridin-1-yl]methyl]-3-[[(2~{S})-oxetan-2-yl]methyl]imidazo[4,5-b]pyridine-5-carboxylic acid, Glucagon-like peptide 1 receptor, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... 著者 Ma, H, Yuan, D.P, Huang, W, Wenge, Z, Xu, E. 登録日 2020-05-07 公開日 2020-08-26 最終更新日 2020-12-16 実験手法 ELECTRON MICROSCOPY (4.2 Å) 主引用文献 Structural insights into the activation of GLP-1R by a small molecule agonist. Cell Res., 30, 2020
6WWZ	Cryo-EM structure of the human chemokine receptor CCR6 in complex with CCL20 and a Go protein 分子名称: C-C chemokine receptor type 6,C-C chemokine receptor type 6, C-C motif chemokine 20, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... 著者 Wasilko, D.J, Johnson, Z.L, Ammirati, M, Han, S, Wu, H. 登録日 2020-05-09 公開日 2020-06-24 最終更新日 2020-07-01 実験手法 ELECTRON MICROSCOPY (3.34 Å) 主引用文献 Structural basis for chemokine receptor CCR6 activation by the endogenous protein ligand CCL20. Nat Commun, 11, 2020
6WZG	Human secretin receptor Gs complex 分子名称: Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(s) subunit alpha isoforms short, ... 著者 Piper, S.J, Belousoff, M.J, Danev, R. 登録日 2020-05-13 公開日 2020-08-12 最終更新日 2020-09-02 実験手法 ELECTRON MICROSCOPY (2.3 Å) 主引用文献 Structure and dynamics of the active Gs-coupled human secretin receptor. Nat Commun, 11, 2020
6X1A	Non peptide agonist PF-06882961, bound to Glucagon-Like peptide-1 (GLP-1) Receptor 分子名称: 2-[(4-{6-[(4-cyano-2-fluorophenyl)methoxy]pyridin-2-yl}piperidin-1-yl)methyl]-1-{[(2S)-oxetan-2-yl]methyl}-1H-benzimidazole-6-carboxylic acid, Glucagon-like peptide 1 receptor, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... 著者 Belousoff, M.J, Zhang, X, Danev, R. 登録日 2020-05-18 公開日 2020-09-09 最終更新日 2020-11-18 実験手法 ELECTRON MICROSCOPY (2.5 Å) 主引用文献 Differential GLP-1R Binding and Activation by Peptide and Non-peptide Agonists. Mol.Cell, 80, 2020
6X19	Non peptide agonist CHU-128, bound to Glucagon-Like peptide-1 (GLP-1) Receptor 分子名称: 3-{(1S)-1-[5-(2,2-dimethylmorpholin-4-yl)-2-{(4S)-2-(4-fluoro-3,5-dimethylphenyl)-3-[3-(4-fluoro-1-methyl-1H-indazol-5-yl)-2-oxo-2,3-dihydro-1H-imidazol-1-yl]-4-methyl-2,4,6,7-tetrahydro-5H-pyrazolo[4,3-c]pyridine-5-carbonyl}-1H-indol-1-yl]butyl}-1,2,4-oxadiazol-5(4H)-one, Glucagon-like peptide 1 receptor, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... 著者 Belousoff, M.J, Zhang, X, Danev, R. 登録日 2020-05-18 公開日 2020-09-09 最終更新日 2020-11-18 実験手法 ELECTRON MICROSCOPY (2.1 Å) 主引用文献 Differential GLP-1R Binding and Activation by Peptide and Non-peptide Agonists. Mol.Cell, 80, 2020
6X18	GLP-1 peptide hormone bound to Glucagon-Like peptide-1 (GLP-1) Receptor 分子名称: Glucagon, Glucagon-like peptide 1 receptor, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... 著者 Belousoff, M.J, Zhang, X, Danev, R. 登録日 2020-05-18 公開日 2020-09-09 最終更新日 2020-11-18 実験手法 ELECTRON MICROSCOPY (2.1 Å) 主引用文献 Differential GLP-1R Binding and Activation by Peptide and Non-peptide Agonists. Mol.Cell, 80, 2020
6XBK	Structure of human SMO-G111C/I496C complex with Gi 分子名称: CHOLESTEROL, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... 著者 Qi, X, Long, T, Li, X. 登録日 2020-06-06 公開日 2020-09-30 最終更新日 2020-11-25 実験手法 ELECTRON MICROSCOPY (3.24 Å) 主引用文献 Sterols in an intramolecular channel of Smoothened mediate Hedgehog signaling. Nat.Chem.Biol., 16, 2020
6XBM	Structure of human SMO-Gi complex with 24(S),25-EC 分子名称: 17-[3-(3,3-DIMETHYL-OXIRANYL)-1-METHYL-PROPYL]-10,13-DIMETHYL-2,3,4,7,8,9,10,11,12,13,14,15,16,17-TETRADECAHYDRO-1H-CYC LOPENTA[A]PHENANTHREN-3-OL, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... 著者 Qi, X, Long, T, Li, X. 登録日 2020-06-06 公開日 2020-09-30 最終更新日 2020-11-25 実験手法 ELECTRON MICROSCOPY (3.15 Å) 主引用文献 Sterols in an intramolecular channel of Smoothened mediate Hedgehog signaling. Nat.Chem.Biol., 16, 2020
6XBL	Structure of human SMO-Gi complex with SAG 分子名称: 3-chloro-N-[trans-4-(methylamino)cyclohexyl]-N-{[3-(pyridin-4-yl)phenyl]methyl}-1-benzothiophene-2-carboxamide, CHOLESTEROL, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... 著者 Qi, X, Li, X. 登録日 2020-06-06 公開日 2020-09-30 最終更新日 2020-11-25 実験手法 ELECTRON MICROSCOPY (3.9 Å) 主引用文献 Sterols in an intramolecular channel of Smoothened mediate Hedgehog signaling. Nat.Chem.Biol., 16, 2020

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