6X19

Non peptide agonist CHU-128, bound to Glucagon-Like peptide-1 (GLP-1) Receptor

Summary for 6X19

• Entry DOI: 10.2210/pdb6x19/pdb
• Related: 6X18
• EMDB information: 21992 21993 21994
• Descriptor: Guanine nucleotide-binding protein G(s) subunit alpha isoforms short, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... (7 entities in total)
• Functional Keywords: g-coupled protein receptor, gpcr, membrane protein, non-peptide agonist
• Biological source: Homo sapiens (Human); More
• Total number of polymer chains: 5
• Total formula weight: 160992.44

Authors

Belousoff, M.J.,Zhang, X.,Danev, R. (deposition date: 2020-05-18, release date: 2020-09-09, Last modification date: 2020-11-18)

• Primary citation: Zhang, X.,Belousoff, M.J.,Zhao, P.,Kooistra, A.J.,Truong, T.T.,Ang, S.Y.,Underwood, C.R.,Egebjerg, T.,Senel, P.,Stewart, G.D.,Liang, Y.L.,Glukhova, A.,Venugopal, H.,Christopoulos, A.,Furness, S.G.B.,Miller, L.J.,Reedtz-Runge, S.,Langmead, C.J.,Gloriam, D.E.,Danev, R.,Sexton, P.M.,Wootten, D.; Differential GLP-1R Binding and Activation by Peptide and Non-peptide Agonists.; Mol.Cell, 80:485-, 2020; PubMed: 33027691; DOI: 10.1016/j.molcel.2020.09.020

Experimental method

ELECTRON MICROSCOPY (2.1 Å)