7BPH

Crystal structure of GppNHp-bound GNAS in complex with the cyclic peptide inhibitor GN13

Summary for 7BPH

Entry DOI	10.2210/pdb7bph/pdb
Related PRD ID	PRD_002362
Descriptor	Guanine nucleotide-binding protein G(s) subunit alpha isoforms short, GN13, PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER, ... (7 entities in total)
Functional Keywords	g protein, gnas, adenylyl cyclase, active state, inhibitor, mrna display, rapid, cyclic peptide, gsin-1, signaling protein
Biological source	Homo sapiens (Human) More
Total number of polymer chains	2
Total formula weight	46397.79
Authors	Hu, Q.,Dai, S.,Shokat, K.M. (deposition date: 2020-03-22, release date: 2021-03-31, Last modification date: 2023-11-29)
Primary citation	Dai, S.A.,Hu, Q.,Gao, R.,Blythe, E.E.,Touhara, K.K.,Peacock, H.,Zhang, Z.,von Zastrow, M.,Suga, H.,Shokat, K.M. State-selective modulation of heterotrimeric G alpha s signaling with macrocyclic peptides. Cell, 2022 Cited by PubMed: 36170854 DOI: 10.1016/j.cell.2022.09.019 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.57 Å)

Structure validation