7BPH
Crystal structure of GppNHp-bound GNAS in complex with the cyclic peptide inhibitor GN13
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Guanine nucleotide-binding protein G(s) subunit alpha isoforms short | polymer | 377 | 44090.9 | 1 | UniProt (P63092) Pfam (PF00503) | Homo sapiens (Human) | Adenylate cyclase-stimulating G alpha protein |
| 2 | B (B) | GN13 | polymer | 16 | 1632.9 | 1 | BIRD (PRD_002362) | synthetic construct | |
| 3 | C (A) | PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER | non-polymer | 522.2 | 1 | Chemie (GNP) | |||
| 4 | D (A) | MAGNESIUM ION | non-polymer | 24.3 | 1 | Chemie (MG) | |||
| 5 | E (A) | GLYCEROL | non-polymer | 92.1 | 1 | Chemie (GOL) | |||
| 6 | F (A) | CHLORIDE ION | non-polymer | 35.5 | 1 | Chemie (CL) | |||
| 7 | G, H (A, B) | water | water | 18.0 | 132 | Chemie (HOH) |
Sequence modifications
A: 7 - 394 (UniProt: P63092)
| PDB | External Database | Details |
|---|---|---|
| Ala 4 | - | expression tag |
| His 5 | - | expression tag |
| Met 6 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 45723.7 | |
| Non-Polymers* | Number of molecules | 4 |
| Total formula weight | 674.0 | |
| All* | Total formula weight | 46397.8 |
