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7T90
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Cryo-EM structure of ACh-bound M2R-Go signaling complex in S2 state
分子名称: ACETYLCHOLINE, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ...
著者Xu, J, Wang, Q, Du, Y, Kobilka, B.K.
登録日2021-12-17
公開日2023-01-25
最終更新日2024-02-07
実験手法ELECTRON MICROSCOPY (3.32 Å)
主引用文献Structural and dynamic insights into supra-physiological activation and allosteric modulation of a muscarinic acetylcholine receptor.
Nat Commun, 14, 2023
8WDT
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Crystal structure of the human adenosine A2A receptor in complex with photoresponsive ligand photoNECA(blue)
分子名称: (2S,3S,4R,5R)-5-(6-amino-2-((E)-phenyldiazenyl)-9H-purin-9-yl)-N-ethyl-3,4-dihydroxytetrahydrofuran-2-carboxamide, Adenosine receptor A2a, Antibody Fab fragment heavy chain, ...
著者Araya, T, Asada, H, Iwata, S, Im, D.H.
登録日2023-09-16
公開日2024-01-17
実験手法X-RAY DIFFRACTION (3.34 Å)
主引用文献Crystal structure reveals the binding mode and selectivity of a photoswitchable ligand for the adenosine A 2A receptor.
Biochem.Biophys.Res.Commun., 695, 2023
8IYX
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Cryo-EM structure of the GPR34 receptor in complex with the antagonist YL-365
分子名称: 1-[4-(3-chlorophenyl)phenyl]carbonyl-4-[2-(4-phenylmethoxyphenyl)ethanoylamino]piperidine-4-carboxylic acid, Probable G-protein coupled receptor 34,YL-365
著者Jia, G.W, Wang, X, Zhang, C.B, Dong, H.H, Su, Z.M.
登録日2023-04-06
公開日2024-03-20
実験手法ELECTRON MICROSCOPY (3.34 Å)
主引用文献Cryo-EM structures of human GPR34 enable the identification of selective antagonists.
Proc.Natl.Acad.Sci.USA, 120, 2023
6WWZ
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Cryo-EM structure of the human chemokine receptor CCR6 in complex with CCL20 and a Go protein
分子名称: C-C chemokine receptor type 6,C-C chemokine receptor type 6, C-C motif chemokine 20, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ...
著者Wasilko, D.J, Johnson, Z.L, Ammirati, M, Han, S, Wu, H.
登録日2020-05-09
公開日2020-06-24
最終更新日2020-07-01
実験手法ELECTRON MICROSCOPY (3.34 Å)
主引用文献Structural basis for chemokine receptor CCR6 activation by the endogenous protein ligand CCL20.
Nat Commun, 11, 2020
3UZC
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Thermostabilised Adenosine A2A receptor in complex with 4-(3-amino-5-phenyl-1,2,4-triazin-6-yl)-2-chlorophenol
分子名称: 4-(3-amino-5-phenyl-1,2,4-triazin-6-yl)-2-chlorophenol, Adenosine A2A Receptor
著者Congreve, M, Andrews, S.P, Dore, A.S, Hollenstein, K, Hurrell, E, Langmead, C.J, Mason, J.S, Ng, I.W, Zhukov, A, Weir, M, Marshall, F.H.
登録日2011-12-07
公開日2012-03-21
最終更新日2023-11-08
実験手法X-RAY DIFFRACTION (3.341 Å)
主引用文献Discovery of 1,2,4-Triazine Derivatives as Adenosine A(2A) Antagonists using Structure Based Drug Design
J.Med.Chem., 55, 2012
8U4S
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Structure of trimeric CXCR4 in complex with REGN7663 Fab
分子名称: (2R)-1-(hexadecanoyloxy)-3-(phosphonooxy)propan-2-yl (9Z)-octadec-9-enoate, C-X-C chemokine receptor type 4, CHOLESTEROL, ...
著者Saotome, K, McGoldrick, L.L, Franklin, M.C.
登録日2023-09-11
公開日2024-03-13
実験手法ELECTRON MICROSCOPY (3.35 Å)
主引用文献Structural insights into CXCR4 modulation and oligomerization
Biorxiv, 2024
8IU2
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Cryo-EM structure of Long-wave-sensitive opsin 1
分子名称: Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(i) subunit alpha-1, ...
著者Peng, Q, Cheng, X.Y, Li, J, Lu, Q.Y, Li, Y.Y, Zhang, J.
登録日2023-03-23
公開日2024-03-27
実験手法ELECTRON MICROSCOPY (3.35 Å)
主引用文献Cryo-EM structure of Long-wave-sensitive opsin 1
To Be Published
7YMJ
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Cryo-EM structure of alpha1AAR-Nb6 complex bound to tamsulosin
分子名称: Nb6, Tamsulosin, alpha1A-adrenergic receptor
著者Toyoda, Y, Zhu, A, Yan, C, Kobilka, B.K, Liu, X.
登録日2022-07-28
公開日2023-07-05
実験手法ELECTRON MICROSCOPY (3.35 Å)
主引用文献Structural basis of alpha 1A -adrenergic receptor activation and recognition by an extracellular nanobody.
Nat Commun, 14, 2023
5F8U
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Ligand occupancy in crystal structure of beta1-adrenergic receptor previously submitted by Huang et al
分子名称: 4-{[(2S)-3-(tert-butylamino)-2-hydroxypropyl]oxy}-3H-indole-2-carbonitrile, Beta-1 adrenergic receptor
著者Leslie, A.G.W, Warne, A, Tate, C.G.
登録日2015-12-09
公開日2015-12-23
最終更新日2024-01-10
実験手法X-RAY DIFFRACTION (3.35 Å)
主引用文献Ligand occupancy in crystal structure of Beta1 adrenergic G protein coupled receptor
Nat.Struct.Mol.Biol., 22, 2015
8UHB
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Cryo-EM Structure of the Ro5256390-bound hTA1-Gs heterotrimer signaling complex
分子名称: (2R,4S)-4-[(2S)-2-phenylbutyl]-1,3-oxazolidin-2-amine, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ...
著者Zilberg, G, Warren, A.L, Parpounas, A.K, Wacker, D.
登録日2023-10-08
公開日2024-01-10
最終更新日2024-05-01
実験手法ELECTRON MICROSCOPY (3.35 Å)
主引用文献Molecular basis of human trace amine-associated receptor 1 activation.
Nat Commun, 15, 2024
3V2W
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Crystal Structure of a Lipid G protein-Coupled Receptor at 3.35A
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, Sphingosine 1-phosphate receptor 1, Lysozyme chimera, ...
著者Hanson, M.A, Roth, C.B, Jo, E, Griffith, M.T, Scott, F.L, Reinhart, G, Desale, H, Clemons, B, Cahalan, S.M, Schuerer, S.C, Sanna, M.G, Han, G.W, Kuhn, P, Rosen, H, Stevens, R.C, GPCR Network (GPCR)
登録日2011-12-12
公開日2012-02-15
最終更新日2024-04-03
実験手法X-RAY DIFFRACTION (3.35 Å)
主引用文献Crystal structure of a lipid G protein-coupled receptor.
Science, 335, 2012
8U4Q
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Structure of REGN7663 Fab-bound CXCR4/Gi complex
分子名称: C-X-C chemokine receptor type 4, CHOLESTEROL, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ...
著者Saotome, K, McGoldrick, L.L, Franklin, M.C.
登録日2023-09-11
公開日2024-03-13
実験手法ELECTRON MICROSCOPY (3.36 Å)
主引用文献Structural insights into CXCR4 modulation and oligomerization
Biorxiv, 2024
7WV9
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Allosteric modulator ZCZ011 binding to CP55940-bound cannabinoid receptor 1 in complex with Gi protein
分子名称: 2-[(1R,2R,5R)-5-hydroxy-2-(3-hydroxypropyl)cyclohexyl]-5-(2-methyloctan-2-yl)phenol, 6-methyl-3-[(1S)-2-nitro-1-thiophen-2-yl-ethyl]-2-phenyl-1H-indole, Cannabinoid receptor 1, ...
著者Xu, Z, Shao, Z.
登録日2022-02-10
公開日2022-06-15
最終更新日2024-04-03
実験手法ELECTRON MICROSCOPY (3.36 Å)
主引用文献Molecular mechanism of allosteric modulation for the cannabinoid receptor CB1.
Nat.Chem.Biol., 18, 2022
6WHA
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HTR2A bound to 25-CN-NBOH in complex with a mini-Galpha-q protein, beta/gamma subunits and an active-state stabilizing single-chain variable fragment (scFv16) obtained by cryo-electron microscopy (cryoEM)
分子名称: 4-(2-{[(2-hydroxyphenyl)methyl]amino}ethyl)-2,5-dimethoxybenzonitrile, G subunit q (Gi2-mini-Gq chimeric), Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ...
著者Skiniotis, G, Roth, B, Kim, K, Panova, O.
登録日2020-04-07
公開日2020-09-23
実験手法ELECTRON MICROSCOPY (3.36 Å)
主引用文献Structure of a Hallucinogen-Activated Gq-Coupled 5-HT2A Serotonin Receptor
Cell(Cambridge,Mass.), 182, 2020
8IY9
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Structure of Niacin-GPR109A-G protein complex
分子名称: Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(o) subunit alpha, ...
著者Yadav, M.K, Sarma, P, Chami, M, Banerjee, R, Shukla, A.K.
登録日2023-04-04
公開日2024-03-06
最終更新日2024-03-20
実験手法ELECTRON MICROSCOPY (3.37 Å)
主引用文献Structure-guided engineering of biased-agonism in the human niacin receptor via single amino acid substitution.
Nat Commun, 15, 2024
7YAE
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Octreotide-bound SSTR2-Gi complex
分子名称: CHOLESTEROL, DPN-CYS-PHE-DTR-LYS-THR-CYS-THO, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ...
著者Zhao, J, Shao, Z.
登録日2022-06-28
公開日2023-04-19
実験手法ELECTRON MICROSCOPY (3.37 Å)
主引用文献Prospect of acromegaly therapy: molecular mechanism of clinical drugs octreotide and paltusotine.
Nat Commun, 14, 2023
7WU9
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Cryo-EM structure of the human EP3-Gi signaling complex
分子名称: Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(i) subunit alpha-1, ...
著者Suno, R, Sugita, Y, Morimoto, K, Iwasaki, K, Kato, T, Kobayashi, T.
登録日2022-02-07
公開日2022-08-17
最終更新日2023-10-04
実験手法ELECTRON MICROSCOPY (3.375 Å)
主引用文献Structural insights into the G protein selectivity revealed by the human EP3-G i signaling complex.
Cell Rep, 40, 2022
8U4T
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Structure of tetrameric CXCR4 in complex with REGN7663 Fab
分子名称: (2R)-1-(hexadecanoyloxy)-3-(phosphonooxy)propan-2-yl (9Z)-octadec-9-enoate, C-X-C chemokine receptor type 4, CHOLESTEROL, ...
著者Saotome, K, McGoldrick, L.L, Franklin, M.C.
登録日2023-09-11
公開日2024-03-13
実験手法ELECTRON MICROSCOPY (3.38 Å)
主引用文献Structural insights into CXCR4 modulation and oligomerization
Biorxiv, 2024
8I7W
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Cryo-EM structure of GSK256073 bound human hydroxy-carboxylic acid receptor 2 in complex with Gi heterotrimer
分子名称: 8-chloranyl-3-pentyl-7H-purine-2,6-dione, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ...
著者Park, J.H, Ishimoto, N, Park, S.Y.
登録日2023-02-02
公開日2024-02-07
実験手法ELECTRON MICROSCOPY (3.39 Å)
主引用文献Structural basis for ligand recognition and signaling of hydroxy-carboxylic acid receptor 2.
Nat Commun, 14, 2023
8T3V
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Cryo-EM structure of the DHA bound FFA1-Gq complex
分子名称: CHOLESTEROL, DOCOSA-4,7,10,13,16,19-HEXAENOIC ACID, Free fatty acid receptor 1, ...
著者Zhang, X, Tikhonova, I, Milligan, G, Zhang, C.
登録日2023-06-07
公開日2024-01-24
実験手法ELECTRON MICROSCOPY (3.39 Å)
主引用文献Structural basis for the ligand recognition and signaling of free fatty acid receptors.
Sci Adv, 10, 2024
8HPT
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Structure of C5a-pep bound mouse C5aR1 in complex with Go
分子名称: Antibody fragment ScFv16, C5a anaphylatoxin chemotactic receptor 1, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ...
著者Saha, S, Maharana, J, Yadav, M.K, Sarma, P, Chami, M, Banerjee, R, Shukla, A.K.
登録日2022-12-13
公開日2023-10-18
最終更新日2024-07-17
実験手法ELECTRON MICROSCOPY (3.39 Å)
主引用文献Molecular basis of anaphylatoxin binding, activation, and signaling bias at complement receptors.
Cell, 186, 2023
8UNW
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CryoEM structure of beta-2-adrenergic receptor in complex with GTP-bound Gs heterotrimer (Class L)
分子名称: (5R,6R)-6-(methylamino)-5,6,7,8-tetrahydronaphthalene-1,2,5-triol, Beta-2 adrenergic receptor, GUANOSINE-5'-TRIPHOSPHATE, ...
著者Papasergi-Scott, M.M, Skiniotis, G.
登録日2023-10-19
公開日2024-03-06
最終更新日2024-06-05
実験手法ELECTRON MICROSCOPY (3.4 Å)
主引用文献Time-resolved cryo-EM of G-protein activation by a GPCR.
Nature, 629, 2024
8XBE
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Human GPR34 -Gi complex bound to S3E-LysoPS
分子名称: (2~{S})-2-azanyl-3-[[(2~{R})-1-ethoxy-3-[(~{Z})-octadec-9-enoyl]oxy-propan-2-yl]oxy-oxidanyl-phosphoryl]oxy-propanoic acid, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ...
著者Kawahara, R, Shihoya, W, Nureki, O.
登録日2023-12-06
公開日2024-05-15
実験手法ELECTRON MICROSCOPY (3.4 Å)
主引用文献Structural basis for lysophosphatidylserine recognition by GPR34.
Nat Commun, 15, 2024
8X64
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CryoEM structure of the histamine H1 receptor-BRIL/Anti BRIL Fab complex with desloratadine
分子名称: Histamine H1 receptor,Soluble cytochrome b562, desloratadine
著者Wang, D.D, Guo, Q.
登録日2023-11-20
公開日2024-01-17
実験手法ELECTRON MICROSCOPY (3.4 Å)
主引用文献Molecular mechanism of antihistamines recognition and regulation of the histamine H 1 receptor.
Nat Commun, 15, 2024
8UNT
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CryoEM structure of beta-2-adrenergic receptor in complex with GTP-bound Gs heterotrimer (Class I)
分子名称: (5R,6R)-6-(methylamino)-5,6,7,8-tetrahydronaphthalene-1,2,5-triol, Beta-2 adrenergic receptor, GUANOSINE-5'-TRIPHOSPHATE, ...
著者Papasergi-Scott, M.M, Skiniotis, G.
登録日2023-10-19
公開日2024-03-06
最終更新日2024-06-12
実験手法ELECTRON MICROSCOPY (3.4 Å)
主引用文献Time-resolved cryo-EM of G-protein activation by a GPCR.
Nature, 629, 2024

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件を2024-07-17に公開中

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