8U4S

Structure of trimeric CXCR4 in complex with REGN7663 Fab

Summary for 8U4S

• Entry DOI: 10.2210/pdb8u4s/pdb
• EMDB information: 41888 41889 41890 41891 41892 41893 41894
• Descriptor: REGN7663 Fab light chain, REGN7663 Fab heavy chain, C-X-C chemokine receptor type 4, ... (5 entities in total)
• Functional Keywords: gpcr, chemokine receptor, trimer, oligomer, antibody, signaling protein-immune system complex, signaling protein/immune system
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 9
• Total formula weight: 367493.05

Authors

Saotome, K.,McGoldrick, L.L.,Franklin, M.C. (deposition date: 2023-09-11, release date: 2024-03-13)

• Primary citation: Saotome, K.,McGoldrick, L.L.,Ho, J.,Ramlall, T.,Shah, S.,Moore, M.J.,Kim, J.H.,Leidich, R.,Olson, W.C.,Franklin, M.C.; Structural insights into CXCR4 modulation and oligomerization; Biorxiv, 2024; DOI: 10.1101/2024.02.09.579708

Experimental method

ELECTRON MICROSCOPY (3.35 Å)