Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

8U4S

Structure of trimeric CXCR4 in complex with REGN7663 Fab

Functional Information from GO Data

Chain	GOid	namespace	contents
C	0001618	molecular_function	virus receptor activity
C	0001666	biological_process	response to hypoxia
C	0002407	biological_process	dendritic cell chemotaxis
C	0003779	molecular_function	actin binding
C	0004930	molecular_function	G protein-coupled receptor activity
C	0005515	molecular_function	protein binding
C	0005737	cellular_component	cytoplasm
C	0005764	cellular_component	lysosome
C	0005769	cellular_component	early endosome
C	0005770	cellular_component	late endosome
C	0005886	cellular_component	plasma membrane
C	0006091	biological_process	generation of precursor metabolites and energy
C	0006915	biological_process	apoptotic process
C	0006954	biological_process	inflammatory response
C	0006955	biological_process	immune response
C	0007165	biological_process	signal transduction
C	0007186	biological_process	G protein-coupled receptor signaling pathway
C	0007193	biological_process	adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway
C	0007204	biological_process	positive regulation of cytosolic calcium ion concentration
C	0007420	biological_process	brain development
C	0008218	biological_process	bioluminescence
C	0009615	biological_process	response to virus
C	0009897	cellular_component	external side of plasma membrane
C	0009986	cellular_component	cell surface
C	0015026	molecular_function	coreceptor activity
C	0016020	cellular_component	membrane
C	0016477	biological_process	cell migration
C	0016493	molecular_function	C-C chemokine receptor activity
C	0016494	molecular_function	C-X-C chemokine receptor activity
C	0019722	biological_process	calcium-mediated signaling
C	0019955	molecular_function	cytokine binding
C	0019957	molecular_function	C-C chemokine binding
C	0022008	biological_process	neurogenesis
C	0030155	biological_process	regulation of cell adhesion
C	0030334	biological_process	regulation of cell migration
C	0030335	biological_process	positive regulation of cell migration
C	0031252	cellular_component	cell leading edge
C	0031410	cellular_component	cytoplasmic vesicle
C	0031625	molecular_function	ubiquitin protein ligase binding
C	0032027	molecular_function	myosin light chain binding
C	0032991	cellular_component	protein-containing complex
C	0038147	molecular_function	C-X-C motif chemokine 12 receptor activity
C	0038160	biological_process	CXCL12-activated CXCR4 signaling pathway
C	0043130	molecular_function	ubiquitin binding
C	0043217	biological_process	myelin maintenance
C	0046718	biological_process	symbiont entry into host cell
C	0048714	biological_process	positive regulation of oligodendrocyte differentiation
C	0060326	biological_process	cell chemotaxis
C	0070062	cellular_component	extracellular exosome
C	0070098	biological_process	chemokine-mediated signaling pathway
C	0070161	cellular_component	anchoring junction
C	0071345	biological_process	cellular response to cytokine stimulus
C	0120162	biological_process	positive regulation of cold-induced thermogenesis
C	1904018	biological_process	positive regulation of vasculature development
C	2000448	biological_process	positive regulation of macrophage migration inhibitory factor signaling pathway
G	0001618	molecular_function	virus receptor activity
G	0001666	biological_process	response to hypoxia
G	0002407	biological_process	dendritic cell chemotaxis
G	0003779	molecular_function	actin binding
G	0004930	molecular_function	G protein-coupled receptor activity
G	0005515	molecular_function	protein binding
G	0005737	cellular_component	cytoplasm
G	0005764	cellular_component	lysosome
G	0005769	cellular_component	early endosome
G	0005770	cellular_component	late endosome
G	0005886	cellular_component	plasma membrane
G	0006091	biological_process	generation of precursor metabolites and energy
G	0006915	biological_process	apoptotic process
G	0006954	biological_process	inflammatory response
G	0006955	biological_process	immune response
G	0007165	biological_process	signal transduction
G	0007186	biological_process	G protein-coupled receptor signaling pathway
G	0007193	biological_process	adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway
G	0007204	biological_process	positive regulation of cytosolic calcium ion concentration
G	0007420	biological_process	brain development
G	0008218	biological_process	bioluminescence
G	0009615	biological_process	response to virus
G	0009897	cellular_component	external side of plasma membrane
G	0009986	cellular_component	cell surface
G	0015026	molecular_function	coreceptor activity
G	0016020	cellular_component	membrane
G	0016477	biological_process	cell migration
G	0016493	molecular_function	C-C chemokine receptor activity
G	0016494	molecular_function	C-X-C chemokine receptor activity
G	0019722	biological_process	calcium-mediated signaling
G	0019955	molecular_function	cytokine binding
G	0019957	molecular_function	C-C chemokine binding
G	0022008	biological_process	neurogenesis
G	0030155	biological_process	regulation of cell adhesion
G	0030334	biological_process	regulation of cell migration
G	0030335	biological_process	positive regulation of cell migration
G	0031252	cellular_component	cell leading edge
G	0031410	cellular_component	cytoplasmic vesicle
G	0031625	molecular_function	ubiquitin protein ligase binding
G	0032027	molecular_function	myosin light chain binding
G	0032991	cellular_component	protein-containing complex
G	0038147	molecular_function	C-X-C motif chemokine 12 receptor activity
G	0038160	biological_process	CXCL12-activated CXCR4 signaling pathway
G	0043130	molecular_function	ubiquitin binding
G	0043217	biological_process	myelin maintenance
G	0046718	biological_process	symbiont entry into host cell
G	0048714	biological_process	positive regulation of oligodendrocyte differentiation
G	0060326	biological_process	cell chemotaxis
G	0070062	cellular_component	extracellular exosome
G	0070098	biological_process	chemokine-mediated signaling pathway
G	0070161	cellular_component	anchoring junction
G	0071345	biological_process	cellular response to cytokine stimulus
G	0120162	biological_process	positive regulation of cold-induced thermogenesis
G	1904018	biological_process	positive regulation of vasculature development
G	2000448	biological_process	positive regulation of macrophage migration inhibitory factor signaling pathway
R	0001618	molecular_function	virus receptor activity
R	0001666	biological_process	response to hypoxia
R	0002407	biological_process	dendritic cell chemotaxis
R	0003779	molecular_function	actin binding
R	0004930	molecular_function	G protein-coupled receptor activity
R	0005515	molecular_function	protein binding
R	0005737	cellular_component	cytoplasm
R	0005764	cellular_component	lysosome
R	0005769	cellular_component	early endosome
R	0005770	cellular_component	late endosome
R	0005886	cellular_component	plasma membrane
R	0006091	biological_process	generation of precursor metabolites and energy
R	0006915	biological_process	apoptotic process
R	0006954	biological_process	inflammatory response
R	0006955	biological_process	immune response
R	0007165	biological_process	signal transduction
R	0007186	biological_process	G protein-coupled receptor signaling pathway
R	0007193	biological_process	adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway
R	0007204	biological_process	positive regulation of cytosolic calcium ion concentration
R	0007420	biological_process	brain development
R	0008218	biological_process	bioluminescence
R	0009615	biological_process	response to virus
R	0009897	cellular_component	external side of plasma membrane
R	0009986	cellular_component	cell surface
R	0015026	molecular_function	coreceptor activity
R	0016020	cellular_component	membrane
R	0016477	biological_process	cell migration
R	0016493	molecular_function	C-C chemokine receptor activity
R	0016494	molecular_function	C-X-C chemokine receptor activity
R	0019722	biological_process	calcium-mediated signaling
R	0019955	molecular_function	cytokine binding
R	0019957	molecular_function	C-C chemokine binding
R	0022008	biological_process	neurogenesis
R	0030155	biological_process	regulation of cell adhesion
R	0030334	biological_process	regulation of cell migration
R	0030335	biological_process	positive regulation of cell migration
R	0031252	cellular_component	cell leading edge
R	0031410	cellular_component	cytoplasmic vesicle
R	0031625	molecular_function	ubiquitin protein ligase binding
R	0032027	molecular_function	myosin light chain binding
R	0032991	cellular_component	protein-containing complex
R	0038147	molecular_function	C-X-C motif chemokine 12 receptor activity
R	0038160	biological_process	CXCL12-activated CXCR4 signaling pathway
R	0043130	molecular_function	ubiquitin binding
R	0043217	biological_process	myelin maintenance
R	0046718	biological_process	symbiont entry into host cell
R	0048714	biological_process	positive regulation of oligodendrocyte differentiation
R	0060326	biological_process	cell chemotaxis
R	0070062	cellular_component	extracellular exosome
R	0070098	biological_process	chemokine-mediated signaling pathway
R	0070161	cellular_component	anchoring junction
R	0071345	biological_process	cellular response to cytokine stimulus
R	0120162	biological_process	positive regulation of cold-induced thermogenesis
R	1904018	biological_process	positive regulation of vasculature development
R	2000448	biological_process	positive regulation of macrophage migration inhibitory factor signaling pathway

Functional Information from PROSITE/UniProt

site_id	PS00237
Number of Residues	17
Details	G_PROTEIN_RECEP_F1_1 G-protein coupled receptors family 1 signature. SSVlILAFISLDRYLaI

Chain	Residue	Details
R	SER122-ILE138

site_id	PS00290
Number of Residues	7
Details	IG_MHC Immunoglobulins and major histocompatibility complex proteins signature. YACEVTH

Chain	Residue	Details
L	TYR197-HIS203
H	TYR207-HIS213

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	72
Details	Transmembrane: {"description":"Helical; Name=1","evidences":[{"source":"PubMed","id":"20929726","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI2
Number of Residues	180
Details	Topological domain: {"description":"Cytoplasmic","evidences":[{"source":"PubMed","id":"20929726","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI3
Number of Residues	63
Details	Transmembrane: {"description":"Helical; Name=2","evidences":[{"source":"PubMed","id":"20929726","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI4
Number of Residues	150
Details	Topological domain: {"description":"Extracellular","evidences":[{"source":"PubMed","id":"20929726","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI5
Number of Residues	57
Details	Transmembrane: {"description":"Helical; Name=3","evidences":[{"source":"PubMed","id":"20929726","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI6
Number of Residues	57
Details	Transmembrane: {"description":"Helical; Name=4","evidences":[{"source":"PubMed","id":"20929726","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI7
Number of Residues	60
Details	Transmembrane: {"description":"Helical; Name=5","evidences":[{"source":"PubMed","id":"20929726","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI8
Number of Residues	57
Details	Transmembrane: {"description":"Helical; Name=6","evidences":[{"source":"PubMed","id":"20929726","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI9
Number of Residues	57
Details	Transmembrane: {"description":"Helical; Name=7","evidences":[{"source":"PubMed","id":"20929726","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI10
Number of Residues	9
Details	Region: {"description":"Chemokine binding","evidences":[{"source":"PubMed","id":"20929726","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"10825158","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

site_id	SWS_FT_FI11
Number of Residues	12
Details	Region: {"description":"Chemokine binding"}

Chain

Residue

Details

site_id	SWS_FT_FI12
Number of Residues	36
Details	Region: {"description":"Involved in dimerization; when bound to chemokine"}

Chain

Residue

Details

site_id	SWS_FT_FI13
Number of Residues	12
Details	Region: {"description":"Chemokine binding, important for signaling and HIV-1 coreceptor activity"}

Chain

Residue

Details

site_id	SWS_FT_FI14
Number of Residues	63
Details	Region: {"description":"Involved in dimerization"}

Chain

Residue

Details

site_id	SWS_FT_FI15
Number of Residues	6
Details	Motif: {"description":"Important for signaling"}

Chain

Residue

Details

site_id	SWS_FT_FI16
Number of Residues	3
Details	Site: {"description":"Chemokine binding"}

Chain

Residue

Details

site_id	SWS_FT_FI17
Number of Residues	3
Details	Site: {"description":"Chemokine binding","evidences":[{"source":"PubMed","id":"20929726","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"10825158","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

site_id	SWS_FT_FI18
Number of Residues	3
Details	Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)