8UGY

Serotonin 1E receptor (5-HT1eR)-Gi1 Complex bound with Mianserin

Summary for 8UGY

Entry DOI	10.2210/pdb8ugy/pdb
EMDB information	42241
Descriptor	Guanine nucleotide-binding protein G(i) subunit alpha-1, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... (7 entities in total)
Functional Keywords	gpcr, signaling protein
Biological source	Homo sapiens (human) More
Total number of polymer chains	4
Total formula weight	128713.51
Authors	Zilberg, G.,Warren, A.L.,Wacker, D. (deposition date: 2023-10-06, release date: 2024-05-01, Last modification date: 2024-05-08)
Primary citation	Zilberg, G.,Parpounas, A.K.,Warren, A.L.,Fiorillo, B.,Provasi, D.,Filizola, M.,Wacker, D. Structural insights into the unexpected agonism of tetracyclic antidepressants at serotonin receptors 5-HT 1e R and 5-HT 1F R. Sci Adv, 10:eadk4855-eadk4855, 2024 Cited by PubMed: 38630816 DOI: 10.1126/sciadv.adk4855 PDB entries with the same primary citation
Experimental method	ELECTRON MICROSCOPY (3.31 Å)

Structure validation