8UGY
Serotonin 1E receptor (5-HT1eR)-Gi1 Complex bound with Mianserin
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A | Guanine nucleotide-binding protein G(i) subunit alpha-1 | polymer | 354 | 40414.0 | 1 | UniProt (P63096) Pfam (PF00503) In PDB | Homo sapiens (human) | |
2 | B | Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 | polymer | 358 | 39418.1 | 1 | UniProt (P62873) Pfam (PF00400) In PDB | Homo sapiens (human) | Transducin beta chain 1 |
3 | G | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 | polymer | 71 | 7861.1 | 1 | UniProt (P59768) Pfam (PF00631) In PDB | Homo sapiens (human) | G gamma-I |
4 | R | 5-hydroxytryptamine receptor 1E | polymer | 339 | 38822.6 | 1 | UniProt (P28566) Pfam (PF00001) In PDB | Homo sapiens (human) | 5-HT-1E,5-HT1E,S31,Serotonin receptor 1E |
5 | R | CHOLESTEROL | non-polymer | 386.7 | 5 | Chemie (CLR) | |||
6 | R | Mianserin | non-polymer | 264.4 | 1 | Chemie (WRU) | |||
7 | water | water | 18.0 | 1 | Chemie (HOH) |
Sequence modifications
A: 1 - 354 (UniProt: P63096)
B: 7 - 340 (UniProt: P62873)
R: 20 - 358 (UniProt: P28566)
PDB | External Database | Details |
---|---|---|
Asn 47 | Ser 47 | engineered mutation |
Ala 203 | Gly 203 | engineered mutation |
Ala 245 | Glu 245 | engineered mutation |
Ser 326 | Ala 326 | engineered mutation |
PDB | External Database | Details |
---|---|---|
Met -17 | - | expression tag |
His -16 | - | expression tag |
His -15 | - | expression tag |
His -14 | - | expression tag |
His -13 | - | expression tag |
His -12 | - | expression tag |
His -11 | - | expression tag |
Leu -10 | - | expression tag |
Glu -9 | - | expression tag |
Val -8 | - | expression tag |
Leu -7 | - | expression tag |
Phe -6 | - | expression tag |
Gln -5 | - | expression tag |
Gly -4 | - | expression tag |
Pro -3 | - | expression tag |
Gly -2 | - | expression tag |
Ser -1 | - | expression tag |
Ser 0 | - | expression tag |
Gly 1 | - | expression tag |
Ser 2 | - | expression tag |
Glu 3 | - | expression tag |
Leu 4 | - | expression tag |
Asp 5 | - | expression tag |
Gln 6 | - | expression tag |
PDB | External Database | Details |
---|---|---|
Trp 111 | Leu 111 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 4 |
Total formula weight | 126515.9 | |
Non-Polymers* | Number of molecules | 6 |
Total formula weight | 2197.6 | |
All* | Total formula weight | 128713.5 |