3UZC

Thermostabilised Adenosine A2A receptor in complex with 4-(3-amino-5-phenyl-1,2,4-triazin-6-yl)-2-chlorophenol

Summary for 3UZC

Related3UZA 3PWH 3RFM 3REY
DescriptorAdenosine A2A Receptor, 4-(3-amino-5-phenyl-1,2,4-triazin-6-yl)-2-chlorophenol (2 entities in total)
Functional Keywords7tm, gpcr, g-protein, membrane protein, signaling protein
Biological sourceHomo sapiens (human)
Cellular locationCell membrane; Multi-pass membrane protein P29274
Total number of polymer chains1
Total molecular weight36777.83
Authors
Primary citation
Congreve, M.,Andrews, S.P.,Dore, A.S.,Hollenstein, K.,Hurrell, E.,Langmead, C.J.,Mason, J.S.,Ng, I.W.,Tehan, B.,Zhukov, A.,Weir, M.,Marshall, F.H.
Discovery of 1,2,4-Triazine Derivatives as Adenosine A(2A) Antagonists using Structure Based Drug Design
J.Med.Chem., 55:1898-1903, 2012
PubMed: 22220592 (PDB entries with the same primary citation)
DOI: 10.1021/jm201376w
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (3.341 Å)
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Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers0.294150.3%010.7%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution

More Asymmetric unit images

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