Thermostabilised Adenosine A2A receptor in complex with 6-(2,6-Dimethylpyridin-4-yl)-5-phenyl-1,2,4-triazin-3-amine

Summary for 3UZA

Related3UZC 3PWH 3REY 3RFM
DescriptorAdenosine receptor A2a, 6-(2,6-dimethylpyridin-4-yl)-5-phenyl-1,2,4-triazin-3-amine (2 entities in total)
Functional Keywords7tm, gpcr, signaling protein, g-protein, membrane protein
Biological sourceHomo sapiens (human)
Cellular locationCell membrane; Multi-pass membrane protein P29274
Total number of polymer chains1
Total molecular weight36756.43
Primary citation
Congreve, M.,Andrews, S.P.,Dore, A.S.,Hollenstein, K.,Hurrell, E.,Langmead, C.J.,Mason, J.S.,Ng, I.W.,Tehan, B.,Zhukov, A.,Weir, M.,Marshall, F.H.
Discovery of 1,2,4-Triazine Derivatives as Adenosine A(2A) Antagonists using Structure Based Drug Design
J.Med.Chem., 55:1898-1903, 2012
PubMed: 22220592 (PDB entries with the same primary citation)
DOI: 10.1021/jm201376w
MImport into Mendeley
Experimental method

Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers0.334220.3%04.5%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution
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