3UZA

Thermostabilised Adenosine A2A receptor in complex with 6-(2,6-Dimethylpyridin-4-yl)-5-phenyl-1,2,4-triazin-3-amine

Summary for 3UZA

Related3UZC 3PWH 3REY 3RFM
DescriptorAdenosine receptor A2a, 6-(2,6-dimethylpyridin-4-yl)-5-phenyl-1,2,4-triazin-3-amine (2 entities in total)
Functional Keywords7tm, gpcr, signaling protein, g-protein, membrane protein
Biological sourceHomo sapiens (human)
Cellular locationCell membrane; Multi-pass membrane protein P29274
Total number of polymer chains1
Total molecular weight36756.43
Authors
Primary citation
Congreve, M.,Andrews, S.P.,Dore, A.S.,Hollenstein, K.,Hurrell, E.,Langmead, C.J.,Mason, J.S.,Ng, I.W.,Tehan, B.,Zhukov, A.,Weir, M.,Marshall, F.H.
Discovery of 1,2,4-Triazine Derivatives as Adenosine A(2A) Antagonists using Structure Based Drug Design
J.Med.Chem., 55:1898-1903, 2012
PubMed: 22220592 (PDB entries with the same primary citation)
DOI: 10.1021/jm201376w
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (3.273 Å)
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Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers0.334220.3%04.5%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution

More Asymmetric unit images

Molmil generated image of 3uza
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Molmil generated image of 3uza
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Molmil generated image of 3uza
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