Thermostabilised Adenosine A2A Receptor

Summary for 3PWH

DescriptorAdenosine receptor A2a, 4-{2-[(7-amino-2-furan-2-yl[1,2,4]triazolo[1,5-a][1,3,5]triazin-5-yl)amino]ethyl}phenol (2 entities in total)
Functional Keywords7tm, gpcr, inverse agonist, g-protein, membrane protein, signaling protein
Biological sourceHomo sapiens (human)
Cellular locationCell membrane; Multi-pass membrane protein P29274
Total number of polymer chains1
Total molecular weight36816.44
Dore, A.S.,Robertson, N.,Errey, J.C.,Ng, I.,Tehan, B.,Hurrell, E.,Magnani, F.,Tate, C.G.,Weir, M.,Marshall, F.H. (deposition date: 2010-12-08, release date: 2011-09-07, Last modification date: 2012-06-20)
Primary citation
Dore, A.S.,Robertson, N.,Errey, J.C.,Ng, I.,Hollenstein, K.,Tehan, B.,Hurrell, E.,Bennett, K.,Congreve, M.,Magnani, F.,Tate, C.G.,Weir, M.,Marshall, F.H.
Structure of the adenosine A(2A) receptor in complex with ZM241385 and the xanthines XAC and caffeine
Structure, 19:1283-1293, 2011
PubMed: 21885291 (PDB entries with the same primary citation)
DOI: 10.1016/j.str.2011.06.014
MImport into Mendeley
Experimental method

Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers0.326171.0%0.4%4.5%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution

More Asymmetric unit images

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Molmil generated image of 3pwh
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Molmil generated image of 3pwh
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