3UZC

Thermostabilised Adenosine A2A receptor in complex with 4-(3-amino-5-phenyl-1,2,4-triazin-6-yl)-2-chlorophenol

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Functional Information from GO Data

ChainGOidnamespacecontents
A0030673cellular_componentaxolemma
A0030425cellular_componentdendrite
A0098978cellular_componentglutamatergic synapse
A0000139cellular_componentGolgi membrane
A0005887cellular_componentintegral component of plasma membrane
A0099055cellular_componentintegral component of postsynaptic membrane
A0099056cellular_componentintegral component of presynaptic membrane
A0005882cellular_componentintermediate filament
A0016020cellular_componentmembrane
A0043025cellular_componentneuronal cell body
A0005886cellular_componentplasma membrane
A0014069cellular_componentpostsynaptic density
A0048786cellular_componentpresynaptic active zone
A0051393molecular_functionalpha-actinin binding
A0019899molecular_functionenzyme binding
A0001609molecular_functionG protein-coupled adenosine receptor activity
A0042802molecular_functionidentical protein binding
A0046982molecular_functionprotein heterodimerization activity
A0031802molecular_functiontype 5 metabotropic glutamate receptor binding
A0007189biological_processadenylate cyclase-activating G protein-coupled receptor signaling pathway
A0007188biological_processadenylate cyclase-modulating G protein-coupled receptor signaling pathway
A0006915biological_processapoptotic process
A0048143biological_processastrocyte activation
A0008015biological_processblood circulation
A0007596biological_processblood coagulation
A0007267biological_processcell-cell signaling
A0006968biological_processcellular defense response
A0044267biological_processcellular protein metabolic process
A0007417biological_processcentral nervous system development
A0042755biological_processeating behavior
A0060079biological_processexcitatory postsynaptic potential
A0007186biological_processG protein-coupled receptor signaling pathway
A0006954biological_processinflammatory response
A0060080biological_processinhibitory postsynaptic potential
A0007626biological_processlocomotory behavior
A0051899biological_processmembrane depolarization
A0046636biological_processnegative regulation of alpha-beta T cell activation
A0008285biological_processnegative regulation of cell proliferation
A0043154biological_processnegative regulation of cysteine-type endopeptidase activity involved in apoptotic process
A0050728biological_processnegative regulation of inflammatory response
A0040013biological_processnegative regulation of locomotion
A0043524biological_processnegative regulation of neuron apoptotic process
A0006469biological_processnegative regulation of protein kinase activity
A0043116biological_processnegative regulation of vascular permeability
A0048812biological_processneuron projection morphogenesis
A0006909biological_processphagocytosis
A0014057biological_processpositive regulation of acetylcholine secretion, neurotransmission
A2001235biological_processpositive regulation of apoptotic signaling pathway
A0045938biological_processpositive regulation of circadian sleep/wake cycle, sleep
A0014049biological_processpositive regulation of glutamate secretion
A1900273biological_processpositive regulation of long-term synaptic potentiation
A0050714biological_processpositive regulation of protein secretion
A0035815biological_processpositive regulation of renal sodium excretion
A0032230biological_processpositive regulation of synaptic transmission, GABAergic
A0051968biological_processpositive regulation of synaptic transmission, glutamatergic
A0035810biological_processpositive regulation of urine volume
A0060134biological_processprepulse inhibition
A0007205biological_processprotein kinase C-activating G protein-coupled receptor signaling pathway
A0051924biological_processregulation of calcium ion transport
A0051881biological_processregulation of mitochondrial membrane potential
A0014061biological_processregulation of norepinephrine secretion
A2000300biological_processregulation of synaptic vesicle exocytosis
A0006355biological_processregulation of transcription, DNA-templated
A0001975biological_processresponse to amphetamine
A0031000biological_processresponse to caffeine
A0007600biological_processsensory perception
A0007271biological_processsynaptic transmission, cholinergic
A0001963biological_processsynaptic transmission, dopaminergic
A0035249biological_processsynaptic transmission, glutamatergic
A0042311biological_processvasodilation
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Functional Information from PDB Data

site_idNumber of ResiduesDetails
AC19BINDING SITE FOR RESIDUE T4E A 330
ChainResidue
AVAL84
ALEU85
APHE168
ALEU249
AHIS250
AASN253
AILE274
AALA277
AHIS278

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Functional Information from PDB atom coordinates for the "HETATM" binding sites

site_idNumber of ResiduesDetails
T4E_3uzc_A_330154-(3-AMINO-5-PHENYL-1,2,4-TRIAZIN-6-YL)-2-CHLOROPHENOL binding site
ChainResidueligand
AALA59T4E: 4-(3-AMINO-5-PHENYL-1,2,4-TRIAZIN-6-YL)-2-CHLOROPHENOL
AALA63T4E: 4-(3-AMINO-5-PHENYL-1,2,4-TRIAZIN-6-YL)-2-CHLOROPHENOL
AVAL84-LEU85T4E: 4-(3-AMINO-5-PHENYL-1,2,4-TRIAZIN-6-YL)-2-CHLOROPHENOL
APHE168T4E: 4-(3-AMINO-5-PHENYL-1,2,4-TRIAZIN-6-YL)-2-CHLOROPHENOL
AMET177T4E: 4-(3-AMINO-5-PHENYL-1,2,4-TRIAZIN-6-YL)-2-CHLOROPHENOL
AASN181T4E: 4-(3-AMINO-5-PHENYL-1,2,4-TRIAZIN-6-YL)-2-CHLOROPHENOL
ATRP246T4E: 4-(3-AMINO-5-PHENYL-1,2,4-TRIAZIN-6-YL)-2-CHLOROPHENOL
ALEU249-HIS250T4E: 4-(3-AMINO-5-PHENYL-1,2,4-TRIAZIN-6-YL)-2-CHLOROPHENOL
AASN253T4E: 4-(3-AMINO-5-PHENYL-1,2,4-TRIAZIN-6-YL)-2-CHLOROPHENOL
AMET270T4E: 4-(3-AMINO-5-PHENYL-1,2,4-TRIAZIN-6-YL)-2-CHLOROPHENOL
AILE274T4E: 4-(3-AMINO-5-PHENYL-1,2,4-TRIAZIN-6-YL)-2-CHLOROPHENOL
AALA277-HIS278T4E: 4-(3-AMINO-5-PHENYL-1,2,4-TRIAZIN-6-YL)-2-CHLOROPHENOL

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Functional Information from PROSITE/UniProt

site_idNumber of ResiduesDetails
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Functional Information from SwissProt/UniProt

site_idNumber of ResiduesDetails
SWS_FT_FI125Helical; Name=5.
ChainResidueDetails
AMET174-LEU198

SWS_FT_FI224Helical; Name=6.
ChainResidueDetails
AALA235-PHE258

SWS_FT_FI325Helical; Name=1.
ChainResidueDetails
AVAL8-TRP32

SWS_FT_FI424Helical; Name=7.
ChainResidueDetails
ALEU267-TYR290

SWS_FT_FI524Helical; Name=2.
ChainResidueDetails
ATYR43-ILE66

SWS_FT_FI623Helical; Name=3.
ChainResidueDetails
ALEU78-ILE100

SWS_FT_FI723Helical; Name=4.
ChainResidueDetails
AALA121-TRP143

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Catalytic Information from CSA

site_idNumber of ResiduesDetails