Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

3UZC

Thermostabilised Adenosine A2A receptor in complex with 4-(3-amino-5-phenyl-1,2,4-triazin-6-yl)-2-chlorophenol

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0030673	cellular_component	axolemma
A	0030425	cellular_component	dendrite
A	0098978	cellular_component	glutamatergic synapse
A	0000139	cellular_component	Golgi membrane
A	0005887	cellular_component	integral component of plasma membrane
A	0099055	cellular_component	integral component of postsynaptic membrane
A	0099056	cellular_component	integral component of presynaptic membrane
A	0005882	cellular_component	intermediate filament
A	0016020	cellular_component	membrane
A	0043025	cellular_component	neuronal cell body
A	0005886	cellular_component	plasma membrane
A	0014069	cellular_component	postsynaptic density
A	0048786	cellular_component	presynaptic active zone
A	0051393	molecular_function	alpha-actinin binding
A	0019899	molecular_function	enzyme binding
A	0001609	molecular_function	G protein-coupled adenosine receptor activity
A	0042802	molecular_function	identical protein binding
A	0046982	molecular_function	protein heterodimerization activity
A	0031802	molecular_function	type 5 metabotropic glutamate receptor binding
A	0007189	biological_process	adenylate cyclase-activating G protein-coupled receptor signaling pathway
A	0007188	biological_process	adenylate cyclase-modulating G protein-coupled receptor signaling pathway
A	0006915	biological_process	apoptotic process
A	0048143	biological_process	astrocyte activation
A	0008015	biological_process	blood circulation
A	0007596	biological_process	blood coagulation
A	0007267	biological_process	cell-cell signaling
A	0006968	biological_process	cellular defense response
A	0044267	biological_process	cellular protein metabolic process
A	0007417	biological_process	central nervous system development
A	0042755	biological_process	eating behavior
A	0060079	biological_process	excitatory postsynaptic potential
A	0007186	biological_process	G protein-coupled receptor signaling pathway
A	0006954	biological_process	inflammatory response
A	0060080	biological_process	inhibitory postsynaptic potential
A	0007626	biological_process	locomotory behavior
A	0051899	biological_process	membrane depolarization
A	0046636	biological_process	negative regulation of alpha-beta T cell activation
A	0008285	biological_process	negative regulation of cell proliferation
A	0043154	biological_process	negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
A	0050728	biological_process	negative regulation of inflammatory response
A	0040013	biological_process	negative regulation of locomotion
A	0043524	biological_process	negative regulation of neuron apoptotic process
A	0006469	biological_process	negative regulation of protein kinase activity
A	0043116	biological_process	negative regulation of vascular permeability
A	0048812	biological_process	neuron projection morphogenesis
A	0006909	biological_process	phagocytosis
A	0014057	biological_process	positive regulation of acetylcholine secretion, neurotransmission
A	2001235	biological_process	positive regulation of apoptotic signaling pathway
A	0045938	biological_process	positive regulation of circadian sleep/wake cycle, sleep
A	0014049	biological_process	positive regulation of glutamate secretion
A	1900273	biological_process	positive regulation of long-term synaptic potentiation
A	0050714	biological_process	positive regulation of protein secretion
A	0035815	biological_process	positive regulation of renal sodium excretion
A	0032230	biological_process	positive regulation of synaptic transmission, GABAergic
A	0051968	biological_process	positive regulation of synaptic transmission, glutamatergic
A	0035810	biological_process	positive regulation of urine volume
A	0060134	biological_process	prepulse inhibition
A	0007205	biological_process	protein kinase C-activating G protein-coupled receptor signaling pathway
A	0051924	biological_process	regulation of calcium ion transport
A	0051881	biological_process	regulation of mitochondrial membrane potential
A	0014061	biological_process	regulation of norepinephrine secretion
A	2000300	biological_process	regulation of synaptic vesicle exocytosis
A	0006355	biological_process	regulation of transcription, DNA-templated
A	0001975	biological_process	response to amphetamine
A	0031000	biological_process	response to caffeine
A	0007600	biological_process	sensory perception
A	0007271	biological_process	synaptic transmission, cholinergic
A	0001963	biological_process	synaptic transmission, dopaminergic
A	0035249	biological_process	synaptic transmission, glutamatergic
A	0042311	biological_process	vasodilation

Functional Information from PDB Data

site_id

Number of Residues

Details

AC1

BINDING SITE FOR RESIDUE T4E A 330

Chain	Residue
A	VAL84
A	LEU85
A	PHE168
A	LEU249
A	HIS250
A	ASN253
A	ILE274
A	ALA277
A	HIS278

Functional Information from PDB atom coordinates for the "HETATM" binding sites

site_id

Number of Residues

Details

T4E_3uzc_A_330

4-(3-AMINO-5-PHENYL-1,2,4-TRIAZIN-6-YL)-2-CHLOROPHENOL binding site

Chain	Residue	ligand
A	ALA59	T4E: 4-(3-AMINO-5-PHENYL-1,2,4-TRIAZIN-6-YL)-2-CHLOROPHENOL
A	ALA63	T4E: 4-(3-AMINO-5-PHENYL-1,2,4-TRIAZIN-6-YL)-2-CHLOROPHENOL
A	VAL84-LEU85	T4E: 4-(3-AMINO-5-PHENYL-1,2,4-TRIAZIN-6-YL)-2-CHLOROPHENOL
A	PHE168	T4E: 4-(3-AMINO-5-PHENYL-1,2,4-TRIAZIN-6-YL)-2-CHLOROPHENOL
A	MET177	T4E: 4-(3-AMINO-5-PHENYL-1,2,4-TRIAZIN-6-YL)-2-CHLOROPHENOL
A	ASN181	T4E: 4-(3-AMINO-5-PHENYL-1,2,4-TRIAZIN-6-YL)-2-CHLOROPHENOL
A	TRP246	T4E: 4-(3-AMINO-5-PHENYL-1,2,4-TRIAZIN-6-YL)-2-CHLOROPHENOL
A	LEU249-HIS250	T4E: 4-(3-AMINO-5-PHENYL-1,2,4-TRIAZIN-6-YL)-2-CHLOROPHENOL
A	ASN253	T4E: 4-(3-AMINO-5-PHENYL-1,2,4-TRIAZIN-6-YL)-2-CHLOROPHENOL
A	MET270	T4E: 4-(3-AMINO-5-PHENYL-1,2,4-TRIAZIN-6-YL)-2-CHLOROPHENOL
A	ILE274	T4E: 4-(3-AMINO-5-PHENYL-1,2,4-TRIAZIN-6-YL)-2-CHLOROPHENOL
A	ALA277-HIS278	T4E: 4-(3-AMINO-5-PHENYL-1,2,4-TRIAZIN-6-YL)-2-CHLOROPHENOL

Functional Information from PROSITE/UniProt

site_id

Number of Residues

Details

Functional Information from SwissProt/UniProt

site_id

Number of Residues

Details

SWS_FT_FI1

Helical; Name=5.

Chain	Residue	Details
A	MET174-LEU198

SWS_FT_FI2

Helical; Name=6.

Chain	Residue	Details
A	ALA235-PHE258

SWS_FT_FI3

Helical; Name=1.

Chain	Residue	Details
A	VAL8-TRP32

SWS_FT_FI4

Helical; Name=7.

Chain	Residue	Details
A	LEU267-TYR290

SWS_FT_FI5

Helical; Name=2.

Chain	Residue	Details
A	TYR43-ILE66

SWS_FT_FI6

Helical; Name=3.

Chain	Residue	Details
A	LEU78-ILE100

SWS_FT_FI7

Helical; Name=4.

Chain	Residue	Details
A	ALA121-TRP143

Catalytic Information from CSA

site_id

Number of Residues

Details

English ▼

150145

entries
(2019-03-20)

150145

entries available on 2019-03-20
00:00 UTC / 09:00 JST

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