8UH3

Serotonin 1E receptor (5-HT1eR)-Gi1 Complex bound with Setiptiline

Summary for 8UH3

• Entry DOI: 10.2210/pdb8uh3/pdb
• Related: 8UGY
• EMDB information: 42245
• Descriptor: Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(i) subunit alpha-1, 5-hydroxytryptamine receptor 1E, ... (8 entities in total)
• Functional Keywords: complex, gpcr, signaling protein
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 5
• Total formula weight: 159088.23

Authors

Wacker, D.,Parpounas, A.K.,Warren, A.L.,Zilberg, G. (deposition date: 2023-10-06, release date: 2024-05-01, Last modification date: 2024-05-08)

• Primary citation: Zilberg, G.,Parpounas, A.K.,Warren, A.L.,Fiorillo, B.,Provasi, D.,Filizola, M.,Wacker, D.; Structural insights into the unexpected agonism of tetracyclic antidepressants at serotonin receptors 5-HT 1e R and 5-HT 1F R.; Sci Adv, 10:eadk4855-eadk4855, 2024; PubMed: 38630816; DOI: 10.1126/sciadv.adk4855

Experimental method

ELECTRON MICROSCOPY (3.31 Å)