8IYX

Cryo-EM structure of the GPR34 receptor in complex with the antagonist YL-365

Summary for 8IYX

• Entry DOI: 10.2210/pdb8iyx/pdb
• EMDB information: 35832
• Descriptor: Probable G-protein coupled receptor 34,YL-365, 1-[4-(3-chlorophenyl)phenyl]carbonyl-4-[2-(4-phenylmethoxyphenyl)ethanoylamino]piperidine-4-carboxylic acid (2 entities in total)
• Functional Keywords: inhibitor, gpr34 receptor in complex with the antagonist yl-365, membrane protein, membrane protein-inhibitor complex, membrane protein/inhibitor
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 1
• Total formula weight: 66814.89

Authors

Jia, G.W.,Wang, X.,Zhang, C.B.,Dong, H.H.,Su, Z.M. (deposition date: 2023-04-06, release date: 2024-03-20)

• Primary citation: Xia, A.,Yong, X.,Zhang, C.,Lin, G.,Jia, G.,Zhao, C.,Wang, X.,Hao, Y.,Wang, Y.,Zhou, P.,Yang, X.,Deng, Y.,Wu, C.,Chen, Y.,Zhu, J.,Tang, X.,Liu, J.,Zhang, S.,Zhang, J.,Xu, Z.,Hu, Q.,Zhao, J.,Yue, Y.,Yan, W.,Su, Z.,Wei, Y.,Zhou, R.,Dong, H.,Shao, Z.,Yang, S.; Cryo-EM structures of human GPR34 enable the identification of selective antagonists.; Proc.Natl.Acad.Sci.USA, 120:e2308435120-e2308435120, 2023; PubMed: 37733739; DOI: 10.1073/pnas.2308435120

Experimental method

ELECTRON MICROSCOPY (3.34 Å)