8IYX
Cryo-EM structure of the GPR34 receptor in complex with the antagonist YL-365
Functional Information from PROSITE/UniProt
| site_id | PS00237 |
| Number of Residues | 17 |
| Details | G_PROTEIN_RECEP_F1_1 G-protein coupled receptors family 1 signature. ISIiLLGFISLDRYIkI |
| Chain | Residue | Details |
| C | ILE140-ILE156 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 120 |
| Details | TOPO_DOM: Extracellular => ECO:0000269|PubMed:27086875 |
| Chain | Residue | Details |
| C | MET1-TYR61 | |
| C | ARG110-LYS128 | |
| C | THR193-GLU216 | |
| C | SER291-GLU310 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 20 |
| Details | TRANSMEM: Helical; Name=1 => ECO:0000269|PubMed:27086875 |
| Chain | Residue | Details |
| C | SER62-ILE82 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 75 |
| Details | TOPO_DOM: Cytoplasmic => ECO:0000269|PubMed:27086875 |
| Chain | Residue | Details |
| C | HIS83-SER88 | |
| C | LEU150-SER171 | |
| C | SER332-THR381 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 20 |
| Details | TRANSMEM: Helical; Name=2 => ECO:0000269|PubMed:27086875 |
| Chain | Residue | Details |
| C | ILE89-PHE109 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 20 |
| Details | TRANSMEM: Helical; Name=3 => ECO:0000269|PubMed:27086875 |
| Chain | Residue | Details |
| C | VAL129-SER149 |
| site_id | SWS_FT_FI6 |
| Number of Residues | 20 |
| Details | TRANSMEM: Helical; Name=4 => ECO:0000269|PubMed:27086875 |
| Chain | Residue | Details |
| C | ILE172-LEU192 |
| site_id | SWS_FT_FI7 |
| Number of Residues | 20 |
| Details | TRANSMEM: Helical; Name=5 => ECO:0000269|PubMed:27086875 |
| Chain | Residue | Details |
| C | ALA217-SER237 |
| site_id | SWS_FT_FI8 |
| Number of Residues | 20 |
| Details | TRANSMEM: Helical; Name=6 => ECO:0000269|PubMed:27086875 |
| Chain | Residue | Details |
| C | ILE270-ILE290 |
| site_id | SWS_FT_FI9 |
| Number of Residues | 20 |
| Details | TRANSMEM: Helical; Name=7 => ECO:0000269|PubMed:27086875 |
| Chain | Residue | Details |
| C | ILE311-SER331 |
| site_id | SWS_FT_FI10 |
| Number of Residues | 5 |
| Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255 |
| Chain | Residue | Details |
| C | ASN28 | |
| C | ASN36 | |
| C | ASN42 | |
| C | ASN200 | |
| C | ASN295 |
