6EXN
 
 | | Post-catalytic P complex spliceosome with 3' splice site docked | | 分子名称: | GUANOSINE-5'-TRIPHOSPHATE, INOSITOL HEXAKISPHOSPHATE, Intron lariat: UBC4 RNA, ... | | 著者 | Wilkinson, M.E, Fica, S.M, Galej, W.P, Norman, C.M, Newman, A.J, Nagai, K. | | 登録日 | 2017-11-08 | | 公開日 | 2018-01-17 | | 最終更新日 | 2020-10-07 | | 実験手法 | ELECTRON MICROSCOPY (3.7 Å) | | 主引用文献 | Postcatalytic spliceosome structure reveals mechanism of 3'-splice site selection.
Science, 358, 2017
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6FF4
 | | human Bact spliceosome core structure | | 分子名称: | 116 kDa U5 small nuclear ribonucleoprotein component, BUD13 homolog, Cell division cycle 5-like protein, ... | | 著者 | Haselbach, D, Komarov, I, Agafonov, D, Hartmuth, K, Graf, B, Kastner, B, Luehrmann, R, Stark, H. | | 登録日 | 2018-01-03 | | 公開日 | 2018-08-29 | | 最終更新日 | 2020-10-07 | | 実験手法 | ELECTRON MICROSCOPY (3.4 Å) | | 主引用文献 | Structure and Conformational Dynamics of the Human Spliceosomal BactComplex.
Cell, 172, 2018
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6FYX
 | | Structure of a partial yeast 48S preinitiation complex with eIF5 N-terminal domain (model C1) | | 分子名称: | 18S ribosomal RNA, 40S ribosomal protein S0, 40S ribosomal protein S1, ... | | 著者 | Llacer, J.L, Hussain, T, Gordiyenko, Y, Ramakrishnan, V. | | 登録日 | 2018-03-12 | | 公開日 | 2018-12-05 | | 最終更新日 | 2024-04-24 | | 実験手法 | ELECTRON MICROSCOPY (3.5 Å) | | 主引用文献 | Translational initiation factor eIF5 replaces eIF1 on the 40S ribosomal subunit to promote start-codon recognition.
Elife, 7, 2018
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6FEC
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6FYY
 | | Structure of a partial yeast 48S preinitiation complex with eIF5 N-terminal domain (model C2) | | 分子名称: | 18S ribosomal RNA, 40S ribosomal protein S0, 40S ribosomal protein S1, ... | | 著者 | Llacer, J.L, Hussain, T, Gordiyenko, Y, Ramakrishnan, V. | | 登録日 | 2018-03-12 | | 公開日 | 2018-12-05 | | 最終更新日 | 2024-04-24 | | 実験手法 | ELECTRON MICROSCOPY (3.02 Å) | | 主引用文献 | Translational initiation factor eIF5 replaces eIF1 on the 40S ribosomal subunit to promote start-codon recognition.
Elife, 7, 2018
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6GSN
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8PPL
 | | MERS-CoV Nsp1 bound to the human 43S pre-initiation complex | | 分子名称: | 18S rRNA, 40S ribosomal protein S10, 40S ribosomal protein S11, ... | | 著者 | Schubert, K, Karousis, E.D, Ban, I, Lapointe, C.P, Leibundgut, M, Baeumlin, E, Kummerant, E, Scaiola, A, Schoenhut, T, Ziegelmueller, J, Puglisi, J.D, Muehlemann, O, Ban, N. | | 登録日 | 2023-07-07 | | 公開日 | 2023-10-18 | | 最終更新日 | 2024-04-24 | | 実験手法 | ELECTRON MICROSCOPY (2.65 Å) | | 主引用文献 | Universal features of Nsp1-mediated translational shutdown by coronaviruses.
Mol.Cell, 83, 2023
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8PJ2
 | | Structure of human 48S translation initiation complex in AUG recognition state after eIF5-induced GTP hydrolysis by eIF2 (48S-2) | | 分子名称: | 18S rRNA, 40S ribosomal protein S10, 40S ribosomal protein S11, ... | | 著者 | Petrychenko, V, Yi, S.-H, Liedtke, D, Peng, B.Z, Rodnina, M.V, Fischer, N. | | 登録日 | 2023-06-22 | | 公開日 | 2024-08-14 | | 実験手法 | ELECTRON MICROSCOPY (3.4 Å) | | 主引用文献 | Structural basis for translational control by the human 48S initiation complex from codon scanning toward subunit joining
Nat.Struct.Mol.Biol., 2024
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8PJ3
 | | Structure of human 48S translation initiation complex upon transfer of initiator tRNA to eIF5B (48S-3) | | 分子名称: | 18S rRNA, 40S ribosomal protein S10, 40S ribosomal protein S11, ... | | 著者 | Petrychenko, V, Yi, S.-H, Liedtke, D, Peng, B.Z, Rodnina, M.V, Fischer, N. | | 登録日 | 2023-06-22 | | 公開日 | 2024-08-14 | | 実験手法 | ELECTRON MICROSCOPY (3.7 Å) | | 主引用文献 | Structural basis for translational control by the human 48S initiation complex from codon scanning toward subunit joining
Nat.Struct.Mol.Biol., 2024
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8QO9
 | | Cryo-EM structure of a human spliceosomal B complex protomer | | 分子名称: | 116 kDa U5 small nuclear ribonucleoprotein component, MINX pre-mRNA, Microfibrillar-associated protein 1, ... | | 著者 | Zhang, Z, Kumar, V, Dybkov, O, Will, C.L, Urlaub, H, Stark, H, Luehrmann, R. | | 登録日 | 2023-09-28 | | 公開日 | 2024-01-24 | | 最終更新日 | 2024-08-07 | | 実験手法 | ELECTRON MICROSCOPY (5.29 Å) | | 主引用文献 | Cryo-EM analyses of dimerized spliceosomes provide new insights into the functions of B complex proteins.
Embo J., 43, 2024
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8PJ1
 | | Structure of human 48S translation initiation complex in open codon scanning state (48S-1) | | 分子名称: | 18S rRNA, 40S ribosomal protein S10, 40S ribosomal protein S11, ... | | 著者 | Petrychenko, V, Yi, S.-H, Liedtke, D, Peng, B.Z, Rodnina, M.V, Fischer, N. | | 登録日 | 2023-06-22 | | 公開日 | 2024-08-14 | | 実験手法 | ELECTRON MICROSCOPY (3.4 Å) | | 主引用文献 | Structural basis for translational control by the human 48S initiation complex from codon scanning toward subunit joining
Nat.Struct.Mol.Biol., 2024
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8PJ5
 | | Structure of human 48S translation initiation complex after eIF2 release prior 60S subunit joining (48S-5) | | 分子名称: | 18S rRNA, 40S ribosomal protein S10, 40S ribosomal protein S11, ... | | 著者 | Petrychenko, V, Yi, S.-H, Liedtke, D, Peng, B.Z, Rodnina, M.V, Fischer, N. | | 登録日 | 2023-06-22 | | 公開日 | 2024-08-14 | | 実験手法 | ELECTRON MICROSCOPY (2.9 Å) | | 主引用文献 | Structural basis for translational control by the human 48S initiation complex from codon scanning toward subunit joining
Nat.Struct.Mol.Biol., 2024
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8PJ4
 | | Structure of human 48S translation initiation complex after eIF5 release (48S-4) | | 分子名称: | 18S rRNA, 40S ribosomal protein S10, 40S ribosomal protein S11, ... | | 著者 | Petrychenko, V, Yi, S.-H, Liedtke, D, Peng, B.Z, Rodnina, M.V, Fischer, N. | | 登録日 | 2023-06-22 | | 公開日 | 2024-08-14 | | 実験手法 | ELECTRON MICROSCOPY (3.2 Å) | | 主引用文献 | Structural basis for translational control by the human 48S initiation complex from codon scanning toward subunit joining
Nat.Struct.Mol.Biol., 2024
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8R0B
 | | Cryo-EM structure of the cross-exon pre-B+ATP complex | | 分子名称: | 116 kDa U5 small nuclear ribonucleoprotein component, 5'ss oligo, NHP2-like protein 1, ... | | 著者 | Zhang, Z, Kumar, V, Dybkov, O, Will, C.L, Zhong, J, Ludwig, S, Urlaub, H, Kastner, B, Stark, H, Luehrmann, R. | | 登録日 | 2023-10-31 | | 公開日 | 2024-05-22 | | 最終更新日 | 2024-07-10 | | 実験手法 | ELECTRON MICROSCOPY (4.4 Å) | | 主引用文献 | Structural insights into the cross-exon to cross-intron spliceosome switch.
Nature, 630, 2024
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8R08
 | | Cryo-EM structure of the cross-exon pre-B+AMPPNP complex | | 分子名称: | 116 kDa U5 small nuclear ribonucleoprotein component, NHP2-like protein 1, N-terminally processed, ... | | 著者 | Zhang, Z, Kumar, V, Dybkov, O, Will, C.L, Zhong, J, Ludwig, S, Urlaub, H, Kastner, B, Stark, H, Luehrmann, R. | | 登録日 | 2023-10-31 | | 公開日 | 2024-05-22 | | 最終更新日 | 2024-07-10 | | 実験手法 | ELECTRON MICROSCOPY (6.1 Å) | | 主引用文献 | Structural insights into the cross-exon to cross-intron spliceosome switch.
Nature, 630, 2024
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8QP9
 | | Cryo-EM Structure of Pre-B+AMPPNP Complex (core part) | | 分子名称: | 116 kDa U5 small nuclear ribonucleoprotein component, INOSITOL HEXAKISPHOSPHATE, Pre-mRNA-processing factor 6, ... | | 著者 | Zhang, Z, Kumar, V, Dybkov, O, Will, C.L, Zhong, J, Ludwig, S, Urlaub, H, Kastner, B, Stark, H, Luehrmann, R. | | 登録日 | 2023-09-30 | | 公開日 | 2024-05-22 | | 最終更新日 | 2024-07-10 | | 実験手法 | ELECTRON MICROSCOPY (4.1 Å) | | 主引用文献 | Structural insights into the cross-exon to cross-intron spliceosome switch.
Nature, 630, 2024
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8QPK
 | | Cryo-EM Structure of Pre-B+5'ss Complex (core part) | | 分子名称: | 116 kDa U5 small nuclear ribonucleoprotein component, 5'ss oligo, INOSITOL HEXAKISPHOSPHATE, ... | | 著者 | Zhang, Z, Kumar, V, Dybkov, O, Will, C.L, Zhong, J, Ludwig, S, Urlaub, H, Kastner, B, Stark, H, Luehrmann, R. | | 登録日 | 2023-10-02 | | 公開日 | 2024-05-22 | | 最終更新日 | 2024-07-10 | | 実験手法 | ELECTRON MICROSCOPY (4.2 Å) | | 主引用文献 | Structural insights into the cross-exon to cross-intron spliceosome switch.
Nature, 630, 2024
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8RM5
 | | Cryo-EM structure of the cross-exon pre-B+5'ssLNG+ATPyS complex | | 分子名称: | 116 kDa U5 small nuclear ribonucleoprotein component, 5'SS oligo, NHP2-like protein 1, ... | | 著者 | Zhang, Z, Kumar, V, Dybkov, O, Will, C.L, Zhong, J, Ludwig, S, Urlaub, H, Kastner, B, Stark, H, Luehrmann, R. | | 登録日 | 2024-01-05 | | 公開日 | 2024-05-22 | | 最終更新日 | 2024-07-10 | | 実験手法 | ELECTRON MICROSCOPY (6.9 Å) | | 主引用文献 | Structural insights into the cross-exon to cross-intron spliceosome switch.
Nature, 630, 2024
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8R09
 | | Cryo-EM structure of the cross-exon pre-B+5'ss+ATPgammaS complex | | 分子名称: | 116 kDa U5 small nuclear ribonucleoprotein component, 5'ss oligo, NHP2-like protein 1, ... | | 著者 | Zhang, Z, Kumar, V, Dybkov, O, Will, C.L, Zhong, J, Ludwig, S, Urlaub, H, Kastner, B, Stark, H, Luehrmann, R. | | 登録日 | 2023-10-31 | | 公開日 | 2024-05-22 | | 最終更新日 | 2024-07-10 | | 実験手法 | ELECTRON MICROSCOPY (4.3 Å) | | 主引用文献 | Structural insights into the cross-exon to cross-intron spliceosome switch.
Nature, 630, 2024
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8QXD
 | | Cryo-EM structure of the cross-exon pre-B complex | | 分子名称: | 116 kDa U5 small nuclear ribonucleoprotein component, NHP2-like protein 1, N-terminally processed, ... | | 著者 | Zhang, Z, Kumar, V, Dybkov, O, Will, C.L, Zhong, J, Ludwig, S, Urlaub, H, Kastner, B, Stark, H, Luehrmann, R. | | 登録日 | 2023-10-24 | | 公開日 | 2024-05-22 | | 最終更新日 | 2024-07-10 | | 実験手法 | ELECTRON MICROSCOPY (9.6 Å) | | 主引用文献 | Structural insights into the cross-exon to cross-intron spliceosome switch.
Nature, 630, 2024
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8QZS
 | | Cryo-EM structure of the cross-exon B-like complex | | 分子名称: | 116 kDa U5 small nuclear ribonucleoprotein component, Microfibrillar-associated protein 1, NHP2-like protein 1, ... | | 著者 | Zhang, Z, Kumar, V, Dybkov, O, Will, C.L, Zhong, J, Ludwig, S, Urlaub, H, Kastner, B, Stark, H, Luehrmann, R. | | 登録日 | 2023-10-29 | | 公開日 | 2024-05-22 | | 最終更新日 | 2024-07-10 | | 実験手法 | ELECTRON MICROSCOPY (4.1 Å) | | 主引用文献 | Structural insights into the cross-exon to cross-intron spliceosome switch.
Nature, 630, 2024
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8QP8
 | | Cryo-EM Structure of Pre-B Complex (core part) | | 分子名称: | 116 kDa U5 small nuclear ribonucleoprotein component, INOSITOL HEXAKISPHOSPHATE, Pre-mRNA-processing factor 6, ... | | 著者 | Zhang, Z, Kumar, V, Dybkov, O, Will, C.L, Zhong, J, Ludwig, S, Urlaub, H, Kastner, B, Stark, H, Luehrmann, R. | | 登録日 | 2023-09-30 | | 公開日 | 2024-05-22 | | 最終更新日 | 2024-07-10 | | 実験手法 | ELECTRON MICROSCOPY (3.5 Å) | | 主引用文献 | Structural insights into the cross-exon to cross-intron spliceosome switch.
Nature, 630, 2024
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8R0A
 | | Cryo-EM structure of the cross-exon pre-B+5'ss complex | | 分子名称: | 116 kDa U5 small nuclear ribonucleoprotein component, 5'ss oligo, NHP2-like protein 1, ... | | 著者 | Zhang, Z, Kumar, V, Dybkov, O, Will, C.L, Zhong, J, Ludwig, S, Urlaub, H, Kastner, B, Stark, H, Luehrmann, R. | | 登録日 | 2023-10-31 | | 公開日 | 2024-05-22 | | 最終更新日 | 2024-07-10 | | 実験手法 | ELECTRON MICROSCOPY (5.8 Å) | | 主引用文献 | Structural insights into the cross-exon to cross-intron spliceosome switch.
Nature, 630, 2024
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8RO1
 | | Structure of the C. elegans Intron Lariat Spliceosome double-primed for disassembly (ILS'') | | 分子名称: | CWF19-like protein 1 homolog, CWF19-like protein 2 homolog, Cell division cycle 5-like protein, ... | | 著者 | Vorlaender, M.K, Rothe, P, Plaschka, C. | | 登録日 | 2024-01-11 | | 公開日 | 2024-08-07 | | 最終更新日 | 2024-08-21 | | 実験手法 | ELECTRON MICROSCOPY (3 Å) | | 主引用文献 | Mechanism for the initiation of spliceosome disassembly.
Nature, 632, 2024
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8RO0
 | | Structure of the C. elegans Intron Lariat Spliceosome primed for disassembly (ILS') | | 分子名称: | Cell division cycle 5-like protein, Coiled-coil domain-containing protein 12, GCF C-terminal domain-containing protein, ... | | 著者 | Vorlaender, M.K, Rothe, P, Plaschka, C. | | 登録日 | 2024-01-11 | | 公開日 | 2024-08-07 | | 最終更新日 | 2024-08-21 | | 実験手法 | ELECTRON MICROSCOPY (2.9 Å) | | 主引用文献 | Mechanism for the initiation of spliceosome disassembly.
Nature, 632, 2024
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