8R08

Cryo-EM structure of the cross-exon pre-B+AMPPNP complex

This is a non-PDB format compatible entry.

Summary for 8R08

• Entry DOI: 10.2210/pdb8r08/pdb
• EMDB information: 18786
• Descriptor: U1 snRNA, Serine/threonine-protein kinase PRP4 homolog, Pre-mRNA-processing-splicing factor 8, ... (50 entities in total)
• Functional Keywords: spliceosome, splicing
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 71
• Total formula weight: 2896352.27

Authors

Zhang, Z.,Kumar, V.,Dybkov, O.,Will, C.L.,Zhong, J.,Ludwig, S.,Urlaub, H.,Kastner, B.,Stark, H.,Luehrmann, R. (deposition date: 2023-10-31, release date: 2024-05-22, Last modification date: 2024-06-05)

• Primary citation: Zhang, Z.,Kumar, V.,Dybkov, O.,Will, C.L.,Zhong, J.,Ludwig, S.E.J.,Urlaub, H.,Kastner, B.,Stark, H.,Luhrmann, R.; Structural insights into the cross-exon to cross-intron spliceosome switch.; Nature, 2024; PubMed: 38778104; DOI: 10.1038/s41586-024-07458-1

Experimental method

ELECTRON MICROSCOPY (6.1 Å)