8PPL

MERS-CoV Nsp1 bound to the human 43S pre-initiation complex

This is a non-PDB format compatible entry.

Summary for 8PPL

• Entry DOI: 10.2210/pdb8ppl/pdb
• Related: 8PPK
• EMDB information: 17805
• Descriptor: Eukaryotic translation initiation factor 3 subunit K, Eukaryotic translation initiation factor 2 subunit 2, Eukaryotic translation initiation factor 2 subunit 3, ... (58 entities in total)
• Functional Keywords: nsp1, mers, sars, sars-cov2, ribosome, 40s ribosomal subunit, translation inhibition, coronavirus, 43s pic, 43s pre-initiation complex, mrna channel, initiation factor, eif2, eif3, eif1, eif1a, viral protein, translation
• Biological source: Middle East respiratory syndrome-related coronavirus; More
• Total number of polymer chains: 52
• Total formula weight: 2078201.58

Authors

Schubert, K.,Karousis, E.D.,Ban, I.,Lapointe, C.P.,Leibundgut, M.,Baeumlin, E.,Kummerant, E.,Scaiola, A.,Schoenhut, T.,Ziegelmueller, J.,Puglisi, J.D.,Muehlemann, O.,Ban, N. (deposition date: 2023-07-07, release date: 2023-10-18, Last modification date: 2024-04-24)

• Primary citation: Schubert, K.,Karousis, E.D.,Ban, I.,Lapointe, C.P.,Leibundgut, M.,Baumlin, E.,Kummerant, E.,Scaiola, A.,Schonhut, T.,Ziegelmuller, J.,Puglisi, J.D.,Muhlemann, O.,Ban, N.; Universal features of Nsp1-mediated translational shutdown by coronaviruses.; Mol.Cell, 83:3546-3557.e8, 2023; PubMed: 37802027; DOI: 10.1016/j.molcel.2023.09.002

Experimental method

ELECTRON MICROSCOPY (2.65 Å)