8R0B

Cryo-EM structure of the cross-exon pre-B+ATP complex

This is a non-PDB format compatible entry.

Summary for 8R0B

• Entry DOI: 10.2210/pdb8r0b/pdb
• EMDB information: 18789
• Descriptor: Pre-mRNA-processing-splicing factor 8, Thioredoxin-like protein 4A, U5 small nuclear ribonucleoprotein 40 kDa protein, ... (46 entities in total)
• Functional Keywords: spliceosome, splicing
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 60
• Total formula weight: 2639422.36

Authors

Zhang, Z.,Kumar, V.,Dybkov, O.,Will, C.L.,Zhong, J.,Ludwig, S.,Urlaub, H.,Kastner, B.,Stark, H.,Luehrmann, R. (deposition date: 2023-10-31, release date: 2024-05-22, Last modification date: 2024-07-10)

• Primary citation: Zhang, Z.,Kumar, V.,Dybkov, O.,Will, C.L.,Zhong, J.,Ludwig, S.E.J.,Urlaub, H.,Kastner, B.,Stark, H.,Luhrmann, R.; Structural insights into the cross-exon to cross-intron spliceosome switch.; Nature, 630:1012-1019, 2024; PubMed: 38778104; DOI: 10.1038/s41586-024-07458-1

Experimental method

ELECTRON MICROSCOPY (4.4 Å)