8QPK

Cryo-EM Structure of Pre-B+5'ss Complex (core part)

Summary for 8QPK

• Entry DOI: 10.2210/pdb8qpk/pdb
• EMDB information: 18555
• Descriptor: Probable ATP-dependent RNA helicase DDX23, U4 snRNA, U4/U6.U5 small nuclear ribonucleoprotein 27 kDa protein, ... (17 entities in total)
• Functional Keywords: spliceosome, splicing
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 16
• Total formula weight: 1339601.61

Authors

Zhang, Z.,Kumar, V.,Dybkov, O.,Will, C.L.,Zhong, J.,Ludwig, S.,Urlaub, H.,Kastner, B.,Stark, H.,Luehrmann, R. (deposition date: 2023-10-02, release date: 2024-05-22, Last modification date: 2024-06-05)

• Primary citation: Zhang, Z.,Kumar, V.,Dybkov, O.,Will, C.L.,Zhong, J.,Ludwig, S.E.J.,Urlaub, H.,Kastner, B.,Stark, H.,Luhrmann, R.; Structural insights into the cross-exon to cross-intron spliceosome switch.; Nature, 2024; PubMed: 38778104; DOI: 10.1038/s41586-024-07458-1

Experimental method

ELECTRON MICROSCOPY (4.2 Å)