8QPK
Cryo-EM Structure of Pre-B+5'ss Complex (core part)
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (G) | Probable ATP-dependent RNA helicase DDX23 | polymer | 820 | 95785.1 | 1 | UniProt (Q9BUQ8) Pfam (PF00270) Pfam (PF00271) | Homo sapiens (human) | |
| 2 | B (D) | Thioredoxin-like protein 4A | polymer | 142 | 16807.3 | 1 | UniProt (P83876) Pfam (PF02966) | Homo sapiens (human) | DIM1 protein homolog,Spliceosomal U5 snRNP-specific 15 kDa protein,Thioredoxin-like U5 snRNP protein U5-15kD |
| 3 | C (L) | U4/U6 small nuclear ribonucleoprotein Prp31 | polymer | 499 | 55529.0 | 1 | UniProt (Q8WWY3) Pfam (PF01798) Pfam (PF09785) | Homo sapiens (human) | Pre-mRNA-processing factor 31,Serologically defined breast cancer antigen NY-BR-99,U4/U6 snRNP 61 kDa protein,Protein 61K,hPrp31 |
| 4 | D (A) | Pre-mRNA-processing-splicing factor 8 | polymer | 2335 | 273974.3 | 1 | UniProt (Q6P2Q9) Pfam (PF12134) Pfam (PF01398) Pfam (PF08084) Pfam (PF08082) Pfam (PF08083) Pfam (PF10598) Pfam (PF10597) Pfam (PF10596) | Homo sapiens (human) | 220 kDa U5 snRNP-specific protein,PRP8 homolog,Splicing factor Prp8,p220 |
| 5 | E (R) | RNA-binding protein 42 | polymer | 480 | 50477.9 | 1 | UniProt (Q9BTD8) Pfam (PF00076) | Homo sapiens (human) | RNA-binding motif protein 42 |
| 6 | F (U) | Ubiquitin carboxyl-terminal hydrolase 39 | polymer | 565 | 65481.4 | 1 | UniProt (Q53GS9) Pfam (PF02148) Pfam (PF00443) | Homo sapiens (human) | |
| 7 | G (S) | U4/U6.U5 tri-snRNP-associated protein 1 | polymer | 800 | 90414.1 | 1 | UniProt (O43290) Pfam (PF19252) Pfam (PF03343) | Homo sapiens (human) | SNU66 homolog,hSnu66,Squamous cell carcinoma antigen recognized by T-cells 1,SART-1,hSART-1,U4/U6.U5 tri-snRNP-associated 110 kDa protein |
| 8 | H (C) | 116 kDa U5 small nuclear ribonucleoprotein component | polymer | 972 | 109560.6 | 1 | UniProt (Q15029) Pfam (PF16004) Pfam (PF00009) Pfam (PF03144) Pfam (PF14492) Pfam (PF03764) Pfam (PF00679) | Homo sapiens (human) | Elongation factor Tu GTP-binding domain-containing protein 2,SNU114 homolog,hSNU114,U5 snRNP-specific protein,116 kDa,U5-116 kDa |
| 9 | I (5) | U5 snRNA | polymer | 117 | 37254.9 | 1 | GenBank (20330981) | Homo sapiens (human) | |
| 10 | J (4) | U4 snRNA | polymer | 144 | 46181.3 | 1 | GenBank (340142) | Homo sapiens (human) | |
| 11 | K (X) | U4/U6.U5 small nuclear ribonucleoprotein 27 kDa protein | polymer | 155 | 18915.4 | 1 | UniProt (Q8WVK2) Pfam (PF08648) | Homo sapiens (human) | U4/U6.U5 snRNP 27 kDa protein,U4/U6.U5-27K,Nucleic acid-binding protein RY-1,U4/U6.U5 tri-snRNP-associated 27 kDa protein,27K,U4/U6.U5 tri-snRNP-associated protein 3 |
| 12 | L (z) | 5'ss oligo | polymer | 11 | 3555.2 | 1 | Homo sapiens | ||
| 13 | M (6) | U6 snRNA | polymer | 106 | 34098.3 | 1 | GenBank (NR_004394.1) | Homo sapiens (human) | |
| 14 | N (N) | Pre-mRNA-processing factor 6 | polymer | 941 | 107092.2 | 1 | UniProt (O94906) Pfam (PF06424) Pfam (PF14559) Pfam (PF13432) | Homo sapiens (human) | Androgen receptor N-terminal domain-transactivating protein 1,ANT-1,PRP6 homolog,U5 snRNP-associated 102 kDa protein,U5-102 kDa protein |
| 15 | O (B) | U5 small nuclear ribonucleoprotein 200 kDa helicase | polymer | 2136 | 244823.4 | 1 | UniProt (O75643) Pfam (PF21188) Pfam (PF18149) Pfam (PF00270) Pfam (PF00271) Pfam (PF02889) | Homo sapiens (human) | Activating signal cointegrator 1 complex subunit 3-like 1,BRR2 homolog,U5 snRNP-specific 200 kDa protein,U5-200KD |
| 16 | P (7) | Splicing factor 3A subunit 1 | polymer | 793 | 88991.1 | 1 | UniProt (Q15459) Pfam (PF01805) Pfam (PF12230) Pfam (PF00240) | Homo sapiens (human) | SF3a120,Spliceosome-associated protein 114,SAP 114 |
| 17 | Q (A) | INOSITOL HEXAKISPHOSPHATE | non-polymer | 660.0 | 1 | Chemie (IHP) |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 16 |
| Total formula weight | 1338941.6 | |
| Non-Polymers* | Number of molecules | 1 |
| Total formula weight | 660.0 | |
| All* | Total formula weight | 1339601.6 |
